Abstract：
OBJECTIVE:Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia. METHODS:We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). RESULTS:Patients with schizophrenia had a significantly higher P50 gating ratio (p<0.001), longer S1 latency (p<0.05), lower S1 amplitude (p<0.01), and lower P50 difference (p<0.001) than did controls. No significant correlations were found between the P50 gating measures and the PANSS total score or subscale scores in patients with schizophrenia. CONCLUSIONS:These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhu XL,Tan SP,Wang ZR,Zhang JG,Li D,Fan FM,Zhao YL,Zou YZ,Tan YL,Yang F,Zhang XYdoi
10.1016/j.neulet.2017.06.009subject
Has Abstractpub_date
2017-07-13 00:00:00pages
346-350eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30489-5journal_volume
653pub_type
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