Abstract：
:This experiment examined the hypothesis that aging reduces the coupling between system components, resulting in a loss of complexity in behavior. Young (18-23 years), old (60-65 years), and older old (70-75 years) subjects performed rhythmical movement and postural tasks with the index finger. Irregularity of the acceleration dynamics was lower during postural tremor and movement in the old and older old subjects, an age effect that was only observed on the mediolateral axis of motion. Coupling across the axes of motion was significantly higher during rhythmic movement in the elderly but remained unaltered across the tasks in the young adults. The results show that the loss of complexity with aging can be detected even in healthy 60-65-year-olds, but demonstrates the need for postural tremor to be examined on more than a single axis of motion. Our findings suggest that reduced motor adaptability with aging results from a greater demand on task-related reorganization of the motor output.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hong SL,James EG,Newell KMdoi
10.1016/j.neulet.2007.12.056subject
Has Abstractpub_date
2008-03-12 00:00:00pages
119-24issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(08)00027-Xjournal_volume
433pub_type
杂志文章abstract：:DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3' untranslated region (3' UTR) was linked to PD-risk through a mechanism that would implicate a differential binding to microRNA-433 (miR-433). The reduction of the affinity of miR-433 to the 3' UTR...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.05.019
更新日期：2010-07-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90534-r
更新日期：1993-02-19 00:00:00
abstract：:The kynurenine pathway converts tryptophan into various compounds, including L-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid. The hypothesis that endogenously-produced kynurenic acid could have physiological effects was tested in combined entorhinal/hippocam...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)13472-3
更新日期：1997-03-14 00:00:00
abstract：:Contemporary proposals for the pathophysiology of tinnitus due to cochlear damage underscore increased spontaneous activity of auditory brainstem neurons. One of the several consequences of the cochlear injury is the activation of the ERK pathway, suppression of phosphodiestase E activity, and putatively setting a lon...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.10.053
更新日期：2012-12-07 00:00:00
abstract：:Diffusion MRI studies characterizing the changes in white matter (WM) due to vascular cognitive impairment, which includes all forms of small vessel disease are reviewed. We reviewed the usefulness of diffusion methods in discriminating the affected WM regions and its relation to cognitive impairment. These studies we...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2018.12.007
更新日期：2019-02-16 00:00:00
abstract：BACKGROUND:The etiology of neurodegenerative disease remains unclear. Recently, SNP rs11868035, located in an intron of the sterol regulatory element binding factor (SREBF1) gene, was found to be associated with Parkinson's disease (PD) in a large European population in a genome-wide association study. To examine the p...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.11.015
更新日期：2018-01-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02021-3
更新日期：2001-08-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90009-i
更新日期：1991-04-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00103-7
更新日期：1998-02-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.04.026
更新日期：2012-05-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90316-l
更新日期：1991-11-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90143-9
更新日期：1981-11-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90068-5
更新日期：1984-02-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00067-6
更新日期：1998-02-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90808-7
更新日期：1988-07-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90236-6
更新日期：1981-07-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1996-03-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90836-x
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1985-04-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Neuroscience letters
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更新日期：2011-05-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2015-08-18 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：2001-01-26 00:00:00
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(90)90641-l
更新日期：1990-10-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)00860-0
更新日期：2000-03-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1998-08-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12446-0
更新日期：1996-03-08 00:00:00
abstract：:Recent research in social neuroscience proposes a link between mirror neuron system (MNS) and social cognition. The MNS has been proposed to be the neural mechanism underlying action recognition and intention understanding and more broadly social cognition. Pre-motor MNS has been suggested to modulate the motor cortex...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.10.033
更新日期：2009-12-25 00:00:00
abstract：:The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats. Age-matched male Wistar rats were divided into four groups; group I: normal control rats; group II: 6-week fructose-fed rats (FR); group III: 9-week FR; and group IV...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.06.008
更新日期：2008-08-15 00:00:00
