Electrophysiological properties of tissue-cultured nerve cells from senescent mouse.

abstract：:A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cyt...

journal_title：Neuroscience letters

authors： Rosenmann H,Meiner Z,Dresner-Pollak R,Kahana E,Aladjem Z,Grenader T,Wertman E,Abramsky O

更新日期：2004-06-10 00:00:00

abstract：:Chronological changes of dopamine D1 receptor binding were determined in the strionigral system of the rat brain by using [3H]SCH 23390, a highly selective dopamine D1 antagonist, in vitro autoradiography after 90 min of right middle cerebral artery (MCA) occlusion and after such occlusion followed by different period...

journal_title：Neuroscience letters

authors： Nagasawa H,Araki T,Kogure K

更新日期：1992-01-06 00:00:00

abstract：:Two types of cone horizontal cells were identified morphologically in the retina of a trichromatic fish by fluorescent labelling with Lucifer Yellow and confocal laser scanning microscopy. H1 cells are located adjacent to the outer plexiform layer, have large somata, small dendritic fields, and contact all cone types....

journal_title：Neuroscience letters

authors： Braun SC,Kröger RH,Wagner HJ

更新日期：1997-10-17 00:00:00

abstract：:There are numerous polymorphisms within the tau gene but these are in complete linkage disequilibrium and exist as two common extended haplotypes H1 and H2. We have investigated the frequency of these haplotypes in 83 cases of sporadic Alzheimer's disease (AD) using the +34 polymorphism in intron 11 of the tau gene as...

journal_title：Neuroscience letters

authors： Green EK,Thaker U,McDonagh AM,Iwatsubo T,Lambert JC,Chartier-Harlin MC,Harris JM,Pickering-Brown SM,Lendon CL,Mann DM

更新日期：2002-05-17 00:00:00

abstract：:Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. De...

journal_title：Neuroscience letters

authors： Gupte AA,Morris JK,Zhang H,Bomhoff GL,Geiger PC,Stanford JA

更新日期：2010-03-19 00:00:00

abstract：:Although chlorpromazine was shown to greatly inhibit a Ca2+-mediated cell death at favorable concentrations (10(-6)-10(-5) M), it caused a drastic decrease in cell viability at higher concentrations (10(-4)-10(-3) M) in a human neuroblastoma cell line. The toxic effect of chlorpromazine also occurred in Ca2+-free medi...

journal_title：Neuroscience letters

authors： Abe K,Sekizawa T,Kogure K

更新日期：1986-11-21 00:00:00

abstract：:We investigated the role of 5-HT(2A) and 5-HT(2C) receptors in atypical absence seizures (AAS) induced by trans-1,4-bis[2-chloro-benzylaminomethyl] cyclohexane, dihydrocholoride (AY-9944). The total duration and number and mean duration of the spontaneous bursts of slow spike-and-wave discharges (SSWD) that characteri...

journal_title：Neuroscience letters

authors： Bercovici E,Cortez MA,Snead OC 3rd

更新日期：2007-05-11 00:00:00

abstract：:Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorde...

journal_title：Neuroscience letters

authors： Prendes-Alvarez S,Nemeroff CB

更新日期：2018-03-16 00:00:00

abstract：:The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar...

journal_title：Neuroscience letters

authors： Chen F,Rezvani A,Jarrott B,Lawrence AJ

更新日期：1997-12-05 00:00:00

abstract：:Effects of intracellularly applied L-arginine and nicotinamide adenine dinucleotide phosphate (NADPH) on the dark voltage and light responses of retinal rods were studied by means of the whole-cell patch-clamp technique. In this mode an exchange of substances by diffusion between cytosol and pipette medium occurs (Pfl...

journal_title：Neuroscience letters

authors： Tsuyama Y,Nöll GN,Schmidt KF

更新日期：1993-01-04 00:00:00

abstract：:Employing double anterograde axonal tracing in combination with intracortical microstimulation, we examined the distribution patterns of corticosubthalamic inputs from forelimb representations of the dorsal (PMd) and ventral (PMv) divisions of the premotor cortex in the macaque monkey. The inputs from the PMd and PMv ...

journal_title：Neuroscience letters

authors： Nambu A,Tokuno H,Inase M,Takada M

更新日期：1997-12-12 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a very important mitogenic factor with proved neurogenesis effects in the central nervous system. Intranasal administration can bypass blood-brain barrier and deliver drugs into the brain directly. We investigated whether intranasal administration of bFGF at later time points a...

journal_title：Neuroscience letters

authors： Wang ZL,Cheng SM,Ma MM,Ma YP,Yang JP,Xu GL,Liu XF

更新日期：2008-11-28 00:00:00

abstract：:The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells...

journal_title：Neuroscience letters

authors： Benavides J,Dubois A,Gotti B,Bourdiol F,Scatton B

更新日期：1990-06-22 00:00:00

abstract：:The goal of this study was to examine the coupling between visual information and body sway with binocular and monocular vision at two distances from the front wall of a moving room. Ten participants stood as still as possible inside of a moving room facing the front wall in conditions that combined room movement with...

journal_title：Neuroscience letters

authors： Moraes R,Lopes AG,Barela JA

更新日期：2009-09-04 00:00:00

abstract：:Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose...

journal_title：Neuroscience letters

authors： Yefimenko N,Portero-Tresserra M,Martí-Nicolovius M,Guillazo-Blanch G,Vale-Martínez A

更新日期：2013-08-26 00:00:00

abstract：:Activation of the μ-opioid receptor (MOR) and noradrenaline reuptake inhibition (NRI) are well recognized as analgesic principles in acute and chronic pain indications. The novel analgesic tapentadol combines MOR agonism and NRI in a single molecule. The present study used OPRM1 (MOR) knockout (KO) mice to determine t...

journal_title：Neuroscience letters

authors： Kögel B,De Vry J,Tzschentke TM,Christoph T

更新日期：2011-03-17 00:00:00

abstract：:Glucose uptake is increased during motoneuron regeneration. Since this glucose is probably used as an energy source for axonal regeneration we postulated that hypoglycemia might interfere with motoneuron regeneration. In order to partially test this hypothesis we attempted to induce moderate hypoglycemia by fasting ra...

journal_title：Neuroscience letters

authors： Singer PA,Mehler S

更新日期：1983-10-31 00:00:00

abstract：:Rapid presentation event-related functional magnetic resonance imaging was applied to macaque monkeys performing a symmetrically rewarded go/no-go task, to investigate neural correlate of response inhibition. Sensorimotor activation related to the task performance was observed predominantly in the hemisphere contralat...

journal_title：Neuroscience letters

authors： Morita M,Nakahara K,Hayashi T

更新日期：2004-02-19 00:00:00

abstract：:Parkinson's disease is due to a dopamine deficiency caused by the degeneration of midbrain dopamine neurons. Current therapies are aimed to substitute dopamine or to directly stimulate postsynaptic dopamine receptors. However, not all patients profit from current therapies to the same extent, even serious side effects...

journal_title：Neuroscience letters

authors： Schmidt WJ,Mayerhofer A,Meyer A,Kovar KA

更新日期：2002-09-27 00:00:00

abstract：:Several studies have indicated that higher levels of childhood aerobic fitness is associated with superior cognitive function, and this association is disproportionately observed in tasks requiring greater top-down control. We designed the current study to clarify the relationship between childhood fitness and top-dow...

journal_title：Neuroscience letters

authors： Kamijo K,Takeda Y,Takai Y,Haramura M

更新日期：2016-10-06 00:00:00

abstract：:An intraperitoneal injection of 0.1 nmol uridine in rats resulted in a transient excess slow-wave sleep if administered shortly before onset of the dark period. The sleep latency was remarkably shortened. A small dose (0.01 nmol) and larger doses (1, 10, 100 nmol) caused no effect. Uridine at a dose of 0.1 nmol was en...

journal_title：Neuroscience letters

authors： Honda K,Okano Y,Komoda Y,Inoué S

更新日期：1985-11-20 00:00:00

abstract：:Activations of the DLPFC and SMA have been shown to correlate with dual-task walking. However, very few investigations have directly perturbed the activations of these areas to establish a cause-and-effect relationship. The objectives of this study were: 1) to investigate the role of DLPFC and SMA in dual-task walking...

journal_title：Neuroscience letters

authors： Goh HT,Ewing S,Marchuk D,Newton A,Nyangani I

更新日期：2019-04-17 00:00:00

abstract：:Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K(+)-evoked CCKLM overflow was reduced by 0.1-10 microM of...

journal_title：Neuroscience letters

authors： Benoliel JJ,Bourgoin S,Mauborgne A,Legrand JC,Hamon M,Cesselin F

更新日期：1991-04-01 00:00:00

abstract：:The angular distribution of mitotic spindle fibers has been studied in the telencephalic ventricular zone (VZ) of mouse embryos and has been found to be monophasic and invariant during the early cortical histogenesis both in the normal and in a reeler embryo. This observation suggests that the orientation of mitotic s...

journal_title：Neuroscience letters

authors： Landrieu P,Goffinet A

更新日期：1979-06-01 00:00:00

abstract：:In the rat the response of suprachiasmatic nucleus neurons to steady retinal illumination at different adaptation luminances was studied. The results confirm that in this nucleus the discharge rate is more commonly increased than suppressed by light. Interval histograms indicate that a complex process underlies the di...

journal_title：Neuroscience letters

authors： Groos G,Mason R

更新日期：1978-04-01 00:00:00

abstract：:The main purpose of the present paper was: (1) to study the phase synchronization pattern in the gamma-band while performing the classical Shepard-Metzler task of mental rotation; (2) to investigate the role of musical training; and (3) to study hemispheric differences in the degree of synchronization during mental ro...

journal_title：Neuroscience letters

authors： Bhattacharya J,Petsche H,Feldmann U,Rescher B

更新日期：2001-09-21 00:00:00

abstract：:The effects of micro-electrophoretically applied melatonin on the electrical activity of Purkinje cells in the cerebellum of anaesthetized pigeons were studied. The proportion of excitatory and inhibitory responses to the pineal indoleamine varied significantly depending on whether the cells were tested during the day...

journal_title：Neuroscience letters

authors： Demaine C,Semm P

更新日期：1986-12-12 00:00:00

abstract：:The effect of methionine-enkephalin (Met-Enk) on responses of rat brain neostriatum neurones to microiontophoretic application of glutamate was studied in experiments with extracellular recording of spike activity. Met-Enk administered by microiontophoresis was shown to depress the glutamate-induced responses. In para...

journal_title：Neuroscience letters

authors： Kuznetsov VI,Godukhin OV

更新日期：1985-06-12 00:00:00

abstract：:In ten patients with Parkinson's disease (PD) and ten age-matched healthy controls, we applied 15 30-s trains of subthreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area. Ten minutes after rTMS, PD patients showed a significant prolongation of the transcranially evoked sil...

journal_title：Neuroscience letters

authors： Siebner HR,Mentschel C,Auer C,Lehner C,Conrad B

更新日期：2000-04-28 00:00:00

abstract：:This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...

journal_title：Neuroscience letters

authors： Wang X,Ma Q,Wang C

更新日期：2012-09-06 00:00:00