Abstract：
:Calcium antagonists inhibit both the Ca2(+)-dependent and -independent release of endogenous glutamate from intact synaptosomes. In the present study, the inhibitory potency of several different classes of calcium antagonists were determined under conditions that control for an effect of these compounds on the Ca2(+)-independent component of glutamate release. The following order of inhibitory potency was derived: flunarizine and cinnarizine greater than diltiazem greater than verapamil, nifedipine and nimodipine greater than omega-conotoxin much greater than amiloride, phenytoin, gadolinium and nickel. Only the diphenylpiperazine derivatives inhibited Ca2(+)-dependent glutamate release with an IC50 value of less than 10(-5) M. This finding indicates that no one type of presynaptic calcium channel predominantly mediates Ca2(+)-dependent glutamate release from hippocampal mossy fiber terminals. It is suggested that the exocytosis of glutamate from rat hippocampal mossy fiber synaptosomes may be mediated by multiple types of calcium channels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Terrian DM,Dorman RV,Gannon RLdoi
10.1016/0304-3940(90)90836-xsubject
Has Abstractpub_date
1990-11-13 00:00:00pages
211-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90836-Xjournal_volume
119pub_type
杂志文章abstract：:The expression of aquaporin-1 (AQP1) protein, a water channel, in the choroid plexus epithelium was examined in the rat to determine the role of AQP1 in the pathophysiology of systemic hyponatremia. Systemic hyponatremia was produced by coadministration of 30 ml hypotonic dextrose solution (140 mM) intraperitoneally a...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90053-1
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2008.12.002
更新日期：2009-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.10.025
更新日期：2015-11-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)13124-4
更新日期：1996-11-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-04-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2007-12-18 00:00:00
abstract：:An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of pa...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.08.064
更新日期：2006-01-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2013-06-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-09-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90314-5
更新日期：1989-07-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(76)90101-4
更新日期：1976-09-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neulet.2013.10.001
更新日期：2013-11-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90612-d
更新日期：1990-10-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.08.012
更新日期：2013-10-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.01.033
更新日期：2013-02-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90157-3
更新日期：1980-12-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2012-06-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：1991-08-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2008-08-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2008-06-13 00:00:00
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doi：10.1016/s0304-3940(02)00748-6
更新日期：2002-09-20 00:00:00
abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.04.005
更新日期：2012-05-16 00:00:00
abstract：:TRPA1 agonists cinnamaldehyde (CA) and mustard oil (allyl isothiocyanate=AITC) induce heat hyperalgesia and mechanical allodynia in human skin, and sensitize responses of spinal and trigeminal dorsal horn neurons to noxious skin heating in rats. TRPA1 is also implicated in cold nociception. We presently used behaviora...
journal_title：Neuroscience letters
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更新日期：2010-04-12 00:00:00
abstract：:Songbirds and humans use auditory feedback to acquire and maintain their vocalizations. The Bengalese finch (Lonchura striata domestica) is a songbird species that rapidly modifies its vocal output to adhere to an internal song memory. In this species, the left side of the bipartite vocal organ is specialized for prod...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.12.016
更新日期：2013-02-08 00:00:00
abstract：:Alpha-synuclein has been implicated in the pathology of certain neurodegenerative diseases, including Parkinson disease (PD) and dementia with Lewy bodies (LBs). Overexpression of human alpha-synuclein in neuronal cells reduces cell viability, but the precise cellular and molecular mechanisms remain poorly understood....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.02.025
更新日期：2007-04-18 00:00:00
abstract：:Vascular dementia and Alzheimer disease are most common type of dementia. These diseases have been associated with cognitive decline and affected personal behavioral activities. Moreover, the pattern of cerebral blood flow in mild cognitive disorder has appeared as a predictive indication for the development into Alzh...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.04.047
更新日期：2016-06-03 00:00:00
abstract：:Although neural stem cell (NSC) transplantation has been investigated as a promising tool for reconstituting damaged brains, recent evidences suggest that NSCs may rescue the brain via paracrine effects rather than by direct cell replacements. In this study, we attempted to determine the neuroprotective effect of NSC-...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.02.035
更新日期：2008-04-25 00:00:00
