The basal nucleus of Meynert in patients with progressive supranuclear palsy.

Abstract:

:The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrated ranging from 12.6% to 54.1%. In the PSP-Alzheimer patient, the loss of cells amounted to 73.8% and the surviving neurons exhibited a reduction in the nucleolar volume, suggesting a reduced protein synthetic capability. The involvement of the basal nucleus is therefore a usual anatomical feature of PSP. The damage is less severe than generally observed in Alzheimer's disease and biochemical studies are required to state whether this is accompanied by a substantial cholinergic deficit.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tagliavini F,Pilleri G,Bouras C,Constantinidis J

doi

10.1016/0304-3940(84)90217-9

subject

Has Abstract

pub_date

1984-01-27 00:00:00

pages

37-42

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(84)90217-9

journal_volume

44

pub_type

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