Abstract:
:The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrated ranging from 12.6% to 54.1%. In the PSP-Alzheimer patient, the loss of cells amounted to 73.8% and the surviving neurons exhibited a reduction in the nucleolar volume, suggesting a reduced protein synthetic capability. The involvement of the basal nucleus is therefore a usual anatomical feature of PSP. The damage is less severe than generally observed in Alzheimer's disease and biochemical studies are required to state whether this is accompanied by a substantial cholinergic deficit.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tagliavini F,Pilleri G,Bouras C,Constantinidis Jdoi
10.1016/0304-3940(84)90217-9subject
Has Abstractpub_date
1984-01-27 00:00:00pages
37-42issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(84)90217-9journal_volume
44pub_type
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