Abstract：
:For several neurodegenerative disorders, including Parkinson's Disease (PD) and Alzheimer's Disease (AD), microRNAs (miRNAs) have been known to play a crucial role. So, in this study miR-132 and its role in PD cell models was investigated. We wanted to investigate the survival or death pathway involved in PD. We observed the expression levels of miR-132 in MPP+ - treated SH-SY5Y cell line, which acted as a PD cell model, and found an increased expression of miR-132. Moreover, through the Dual-Luciferase® Reporter (DLR™) Assay, it was also revealed that miR-132 targets SIRT1 3'UTR, a histone deacetylase, and decreases its activity, which results in increased acetylation of p53, an apoptotic inducer. p53 acetylation leads to overexpression of other pro-apoptotic genes like Puma and Noxa, which eventually leads to cell death. Here, we show that the upregulation of miR-132 in SH-SY5Y cells can induce apoptosis through the SIRT1/p53 pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Qazi TJ,Lu J,Duru L,Zhao J,Qing Hdoi
10.1016/j.neulet.2020.135465subject
Has Abstractpub_date
2021-01-01 00:00:00pages
135465eissn
0304-3940issn
1872-7972pii
S0304-3940(20)30735-7journal_volume
740pub_type
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