(+)-epi-Clausenamide, but not (-)-epi-clausenamide, showed more potential than (-)-clausenamide on facilitating synaptic transmission in CA1 region of hippocampal synapses.

Abstract:

:Effect of (+)-epi-clausenamide and (-)-epi-clausenamide on synaptic transmission in CA1 region of hippocampal slice was compared in this study. (+)-epi-Clausenamide showed more potency than (-)-clausenamide on either induction or maintenance of long term potentiation (LTP). Effect of (+)-epi-clausenamide on potentiating basic synaptic transmission was also superior to (-)-clausenamide. However, (-)-epi-clausenamide showed only slight effects on synaptic transmission, suggesting that the effect of (+)-epi-clausenamide and (-)-epi-clausenamide on synaptic transmission depended on their chirality. Calcium influx was not involved in (+)-epi-clausenamide facilitating synaptic transmission in this study. (+)-epi-Clausenamide might promote glutamate release through the activation of Synapsin I(Ser9) to activate the downstream effectors which play a key role in synaptic plasticity. Elucidating the mechanism of each optical isomer of clausenamide by electrophysiological methods provided basis for therapeutic strategies for neurological disorders.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ning N,Sun J,Du G,Han N,Zhang J,Chen N

doi

10.1016/j.neulet.2012.06.049

subject

Has Abstract

pub_date

2012-08-15 00:00:00

pages

99-103

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)00857-9

journal_volume

523

pub_type

杂志文章
  • Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain.

    abstract::The effect of sex, postmortem delay and aging on alpha 2-adrenoceptor binding was studied in tissue sections from several representative regions of the human brain from 21 subjects using [3H]UK-14304 as a ligand. Sex and postmortem delay did not influence the density of alpha 2-receptors. Aging resulted in clear decre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90588-k

    authors: Pascual J,del Arco C,González AM,Díaz A,del Olmo E,Pazos A

    更新日期:1991-12-09 00:00:00

  • Infant brain activity while viewing facial movement of point-light displays as measured by near-infrared spectroscopy (NIRS).

    abstract::Adult observers can quickly identify specific actions performed by an invisible actor from the points of lights attached to the actor's head and major joints. Infants are also sensitive to biological motion and prefer to see it depicted by a dynamic point-light display. In detecting biological motion such as whole bod...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.06.086

    authors: Ichikawa H,Kanazawa S,Yamaguchi MK,Kakigi R

    更新日期:2010-09-27 00:00:00

  • Serotonin-immunoreactive structures in the central nervous system of the garfish Lepisosteus productus (Semionotiformes, Osteichthyes).

    abstract::Serotonin-immunoreactive (5HT-IR) neurons were investigated in the brain and rostral (cervical) spinal cord of the garfish, a non-teleost actinopterygian. The diencephalon contained a prominent 5HT-IR cell group consisting mainly of liquor-contacting neurons in the hypothalamic periventricular wall. Their ependymofuga...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)01011-8

    authors: Chiba A,Oka S

    更新日期:1999-02-12 00:00:00

  • Mechanisms and sites of pyrogenic action exerted by staphylococcal enterotoxin A in rabbits.

    abstract::The febrile responses induced by i.v. administrations of staphylococcal enterotoxin A (SEA) was mimicked by direct injection of SEA into the organum vasculosum laminae terminalis (OVLT) in unanesthetized rabbits. Compared with the febrile responses induced by i.v. injection of SEA, the OVLT route of injection required...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00759-3

    authors: Huang WT,Lin MT,Won SJ

    更新日期:1997-10-24 00:00:00

  • Imaging the dynamics of the auditory steady-state evoked response.

    abstract::This study used magnetoencephalography (MEG) to examine the dynamic patterns of neural activity underlying the auditory steady-state response. We examined the continuous time-series of responses to a 32-Hz amplitude modulation. Fluctuations in the amplitude of the evoked response were found to be mediated by non-linea...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.05.043

    authors: Simpson MI,Hadjipapas A,Barnes GR,Furlong PL,Witton C

    更新日期:2005-09-16 00:00:00

  • Occipital cortex activation studied with simultaneous recordings of functional transcranial Doppler ultrasound (fTCD) and visual evoked potential (VEP) in cognitively normal human subjects: effect of healthy aging.

    abstract::We evaluated effect of aging, gender and eye (sighting) dominance on relationship between visual evoked flow response (VEFR) and visual evoked potential (VEP), which refers to neurovascular coupling. The VEFR was defined as a percentage increase of the ratio of mean blood flow velocity in the contralateral (according ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.01.030

    authors: Topcuoglu MA,Aydin H,Saka E

    更新日期:2009-03-06 00:00:00

  • A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.

    abstract::The FE65 protein was previously described interacting with amyloid protein precursor (APP) and mediating its internalization. Hu et al. (Hum. Genet., 103 (1998) 295) recently reported that a deletion polymorphism in intron 13 of the FE65 gene may be protective for sporadic Alzheimer's disease (AD) forms and suggested ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01477-4

    authors: Lambert JC,Mann D,Goumidi L,Harris J,Pasquier F,Frigard B,Cottel D,Lendon C,Iwatsubo T,Amouyel P,Chartier-Harlin MC

    更新日期:2000-10-20 00:00:00

  • Specialized ependymal ridges in the cerebral aqueduct of the rat.

    abstract::Novel paired ependymal ridges (EPRS) have been identified in the ventrolateral wall of the cerebral aqueduct of the rat. Scanning electron microscopic techniques revealed that the dorsolateral and ventromedial ridges differ from each other in surface morphology. Using the PAP immunohistochemical technique, the EPRS de...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90196-8

    authors: Welsh MG,Beitz AJ

    更新日期:1981-11-18 00:00:00

  • Shift type and season affect adaptation of the 6-sulphatoxymelatonin rhythm in offshore oil rig workers.

    abstract::Previously we have shown that the 6-sulphatoxymelatonin rhythm of oil rig workers on a 2-week night shift (1800-0600 h) adapts to the shift via a phase delay. We now report the findings of a study on two offshore drill crews working a 1 week day (1200-0000 h), 1 week night (0000-1200 h) swing shift. Urine samples were...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3940(98)00585-0

    authors: Barnes RG,Forbes MJ,Arendt J

    更新日期:1998-08-21 00:00:00

  • Alzheimer's disease and the autophagic-lysosomal system.

    abstract::Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the presence of proteinopathies, in which misfolded or conformationally altere...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2018.05.017

    authors: Chung KM,Hernández N,Sproul AA,Yu WH

    更新日期:2019-04-01 00:00:00

  • Distribution and ultrastructure of ventral root afferents to lamina I of the cat sacral spinal cord.

    abstract::Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90182-0

    authors: Beattie MS,Bresnahan JC,Mawe GM,Finn S

    更新日期:1987-04-23 00:00:00

  • Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model.

    abstract::Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.02.008

    authors: Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

    更新日期:2010-03-26 00:00:00

  • Specific atrial natriuretic peptide binding sites in rat cerebral capillaries.

    abstract::We examined the specific rat 125I-alpha-rat atrial natriuretic peptide(1-28)[ANF-(99-126)] (125I-rANP) binding sites in the cerebral capillaries from the cerebral cortex of male adult Wistar rats. The binding of 125I-rANP at 37 degrees C was saturable and of high affinity with a Kd of approximately 100 pM and Bmax of ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90254-6

    authors: Niwa M,Ibaragi M,Tsutsumi K,Kurihara M,Himeno A,Mori K,Ozaki M

    更新日期:1988-08-15 00:00:00

  • Acute bouts of active and passive leg cycling attenuate the amplitude of the soleus H-reflex in humans.

    abstract::This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00652-9

    authors: Motl RW,Knowles BD,Dishman RK

    更新日期:2003-08-21 00:00:00

  • Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro.

    abstract::We have investigated the effect of histamine (HA) on spontaneous firing of dopaminergic (DA) and GABAergic neurons in the substantia nigra (SN) and the ventral tegmental area (VTA) of the rat in vitro. Single-unit extracellular recordings were obtained and drugs were bath applied. In both regions application of HA (10...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00050-2

    authors: Korotkova TM,Haas HL,Brown RE

    更新日期:2002-03-08 00:00:00

  • Temporal order judgments for audiovisual targets embedded in unimodal and bimodal distractor streams.

    abstract::We investigated whether the presence of unimodal or bimodal (synchronous) distractors would affect temporal order judgments (TOJs) for pairs of asynchronous audiovisual target stimuli. Participants made unspeeded TOJs regarding which of a pair of auditory and visual stimuli, presented at different stimulus onset async...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.06.017

    authors: Vatakis A,Spence C

    更新日期:2006-11-06 00:00:00

  • Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease characterized by degeneration and death of motor neurons. Aberrant protein aggregation and oxidative stress are implicated in the etiology of ALS; thus preventing propagation of early aggregation events and oxidative damage could be an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.04.035

    authors: Evans TM,Bhattacharya A,Shi Y,Qi W,Block TJ,Chaudhuri A,Chaudhuri AR,Hawker K,Van Remmen H

    更新日期:2016-06-15 00:00:00

  • ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

    abstract::Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have generated SCA17 transgenic mice which recapitulate the patients' phenotyp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135337

    authors: Lin CW,Fan CH,Chang YC,Hsieh-Li HM

    更新日期:2020-11-01 00:00:00

  • The 'M2' electromyographic response to random perturbations of arm movements is missing in long-trained monkeys.

    abstract::Adult monkeys who have been under training over a long period of time show a loss of the M2 component in their biceps electromyographic response to brief, random perturbations of an alternating arm movement, the M1 component being apparently enhanced. These changes of the stretch-induced responses indicate a long-term...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90466-4

    authors: Christakos CN,Wolf H,Meyer-Lohmann J

    更新日期:1983-11-11 00:00:00

  • Spatial memory and learning deficits after experimental pneumococcal meningitis in mice.

    abstract::Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01645-1

    authors: Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

    更新日期:2000-12-22 00:00:00

  • Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.

    abstract::Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical sev...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.05.110

    authors: Moriya M,Nakatsuji Y,Miyamoto K,Okuno T,Kinoshita M,Kumanogoh A,Kusunoki S,Sakoda S

    更新日期:2008-08-08 00:00:00

  • Injection of a cholinergic agonist in the dorsolateral pontine tegmentum of cats affects the posturokinetic responses to cortical stimulation.

    abstract::Microinjection into the dorsolateral pontine tegmentum of the muscarinic agonist bethanechol, leading to activation of cholinoceptive pontine reticular formation (pRF) neurons and the related medullary inhibitory reticulospinal system, did not modify the threshold, latency and amplitude of the forelimb flexion elicite...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90431-8

    authors: Luccarini P,Gahery Y,Pompeiano O

    更新日期:1990-06-22 00:00:00

  • Experimental demonstration of intrinsic synapses in cat's caudate nucleus.

    abstract::The electron microscopic findings in cats after complete interruption of all afferents to caudate nucleus as well as of its efferent fibers, suggest that the type IX synapses, the presynaptic component of which contains large empty round vesicles, are formed by the axon terminals of intrinsic neurons. They make synapt...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(77)90033-7

    authors: Hassler R,Chung JW,Wagner A,Rinne U

    更新日期:1977-07-01 00:00:00

  • Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.

    abstract::Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.11.031

    authors: Kim OJ,Hong SH,Jeon YJ,Oh SH,Kim HS,Park YS,Kim EJ,Kim NK

    更新日期:2013-01-15 00:00:00

  • Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis.

    abstract::1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.10.103

    authors: Ahn KH,Kim YS,Kim SY,Huh Y,Park C,Jeong JW

    更新日期:2009-01-09 00:00:00

  • Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons.

    abstract::The aim of this study was to clarify whether 12-lipoxygenase (12-LOX) activation was involved in reactive oxygen species (ROS) generation, extensive poly(ADP-ribose) polymerase (PARP) activation and neuronal death induced by glucose-deprivation, followed by glucose-reload (GD/R). The decrease of neuronal viability and...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.09.073

    authors: Nagasawa K,Kakuda T,Higashi Y,Fujimoto S

    更新日期:2007-12-18 00:00:00

  • Microtubular packing varies along the course of motor and sensory axons: possible regulation of microtubules by environmental cues.

    abstract::In the toad Xenopus laevis, the microtubular density of 3-microns myelinated fibres was assessed in peripheral nerves, dorsal and ventral roots, and dorsal and ventral funiculi of the spinal cord. In the roots, the axonal microtubular density was 6 microtubules/microns 2 and twice as much at the other sampling sites. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90583-1

    authors: Saitua F,Alvarez J

    更新日期:1989-10-09 00:00:00

  • Fast conducting electrosensory pathway in the mormyrid fish, Gnathonemus petersii.

    abstract::A compound action potential of short latency was recorded from the ganglion mesencephali extrolaterale in response to both the fish's own electric organ discharge and electric stimulation of the whole fish or a branch of the posterior lateral line nerve. The time difference between the response in the nerve, 16 mm fro...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(76)90004-5

    authors: Enger PS,Libouban S,Szabo T

    更新日期:1976-05-01 00:00:00

  • Differentiation chronic post traumatic stress disorder patients from healthy subjects using objective and subjective sleep-related parameters.

    abstract::Sleep disturbance is common in chronic post-traumatic stress disorder (PTSD). However, prior work has demonstrated that there are inconsistencies between subjective and objective assessments of sleep disturbance in PTSD. Therefore, we investigated whether subjective or objective sleep assessment has greater clinical u...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.04.042

    authors: Tahmasian M,Jamalabadi H,Abedini M,Ghadami MR,Sepehry AA,Knight DC,Khazaie H

    更新日期:2017-05-22 00:00:00

  • Evidence for a role of calcineurin in the development of retinocollicular fine topography.

    abstract::The fine-tuning of topographically organized projections in sensory systems is strongly influenced by electrical activity and use-dependent modifications in synaptic strength. Since calcineurin (CaN), a Ca(2+)-calmodulin dependent serine/threonine phosphatase has been associated with activity-dependent modifications i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.09.071

    authors: Trindade P,Antonioli-Santos R,Teixeira AC,Lanzillotta-Mattos B,Melibeu AC,Campello-Costa P,Linden R,Serfaty CA

    更新日期:2011-01-03 00:00:00