Abstract:
:Effect of (+)-epi-clausenamide and (-)-epi-clausenamide on synaptic transmission in CA1 region of hippocampal slice was compared in this study. (+)-epi-Clausenamide showed more potency than (-)-clausenamide on either induction or maintenance of long term potentiation (LTP). Effect of (+)-epi-clausenamide on potentiating basic synaptic transmission was also superior to (-)-clausenamide. However, (-)-epi-clausenamide showed only slight effects on synaptic transmission, suggesting that the effect of (+)-epi-clausenamide and (-)-epi-clausenamide on synaptic transmission depended on their chirality. Calcium influx was not involved in (+)-epi-clausenamide facilitating synaptic transmission in this study. (+)-epi-Clausenamide might promote glutamate release through the activation of Synapsin I(Ser9) to activate the downstream effectors which play a key role in synaptic plasticity. Elucidating the mechanism of each optical isomer of clausenamide by electrophysiological methods provided basis for therapeutic strategies for neurological disorders.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ning N,Sun J,Du G,Han N,Zhang J,Chen Ndoi
10.1016/j.neulet.2012.06.049subject
Has Abstractpub_date
2012-08-15 00:00:00pages
99-103issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(12)00857-9journal_volume
523pub_type
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journal_title:Neuroscience letters
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