Abstract:
:Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Moriya M,Nakatsuji Y,Miyamoto K,Okuno T,Kinoshita M,Kumanogoh A,Kusunoki S,Sakoda Sdoi
10.1016/j.neulet.2008.05.110subject
Has Abstractpub_date
2008-08-08 00:00:00pages
323-6issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(08)00780-5journal_volume
440pub_type
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