Localized brain activation by selective tasks improves specific cognitive functions in humans.

abstract：:The present study was carried out to examine whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) using intracerebral microdialysis techniques. Perfusion with the GABA receptor antagonists as well as agonists was perf...

journal_title：Neuroscience letters

authors： Takahashi M,Nomura M,Tanaka J

更新日期：2016-09-06 00:00:00

abstract：:The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients a...

journal_title：Neuroscience letters

authors： Dyrvig M,Mikkelsen JD,Lichota J

更新日期：2019-06-21 00:00:00

abstract：:We have demonstrated the existence and localization of two angiotensin II (AII) receptor subtypes in different regions of the rat brain using competitive radioligand binding technique. The identification of the subtypes was made by the reciprocal selectivity of DuP 753 and PD123177 for the AII-1 and AII-2 receptors, r...

journal_title：Neuroscience letters

authors： Leung KH,Smith RD,Pieter,Timmermans BM,Chiu AT

更新日期：1991-02-11 00:00:00

abstract：:Mice exposed to intermittent cold stress (ICS), but not constant cold stress (CCS) showed sustained thermal hyperalgesia for up to 12 days. Systemic or intracerebroventricular (i.c.v.) injection of morphine caused no significant analgesia in ICS mice, but induced dose-dependent analgesia in control mice. However, sign...

journal_title：Neuroscience letters

authors： Nishiyori M,Nagai J,Nakazawa T,Ueda H

更新日期：2010-03-26 00:00:00

abstract：:Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry fo...

journal_title：Neuroscience letters

authors： Houtani T,Ikeda M,Kase M,Sato K,Sakuma S,Kakimoto S,Ueyama T,Munemoto Y,Takeshima H,Sugimoto T

更新日期：2003-01-02 00:00:00

abstract：:It has long been known that the steroid hormone progesterone has anticonvulsant actions. These have been documented both in animals and humans. In 2003, we reported that progesterone's first metabolite, 5alpha-dihydroprogesterone (5alpha-DHP), has strong anticonvulsant effects in amygdala-kindled female rats. These oc...

journal_title：Neuroscience letters

authors： Lonsdale D,Burnham WM

更新日期：2007-01-10 00:00:00

abstract：:Peptide histidine-isoleucine (PHI) immunoreactivity was located in amacrine-like cells in adult rat retina by use of immunohistochemical techniques. Immunoreactive somata were found in the proximal part of the inner nuclear layer. From these somata, processes could be followed into the inner plexiform layer. The termi...

journal_title：Neuroscience letters

authors： Mikkelsen JD,Larsen JN,Fahrenkrug J,Møller M

更新日期：1987-08-31 00:00:00

abstract：:Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...

journal_title：Neuroscience letters

authors： Zuiki M,Chiyonobu T,Yoshida M,Maeda H,Yamashita S,Kidowaki S,Hasegawa T,Gotoh H,Nomura T,Ono K,Hosoi H,Morimoto M

更新日期：2017-07-13 00:00:00

abstract：:Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are neurodegenerative diseases that may share genetic risk factors. The exon variant Aal58Val (rs17571) in CTSD was recently associated with AD, leading us to examine whether it also affects risk of ALS and PD. The rs17571 varia...

journal_title：Neuroscience letters

authors： Xi J,Yang X,Zhao Q,Zheng J,An R,Tian S,Huang H,Hu F,Ning P,Xu Y

更新日期：2018-01-01 00:00:00

abstract：:The cellular prion protein (PrP(C)) is crucial for the development of transmissible spongiform encephalopathies (TSEs), where the pathogenic scrapie isoform (PrP(Sc)) of the same protein, is considered to be the principal or sole infectious agent. Here, we report findings on PrP(C) expression in the rat forebrain, usi...

journal_title：Neuroscience letters

authors： Verghese-Nikolakaki S,Michaloudi H,Polymenidou M,Groschup MH,Papadopoulos GC,Sklaviadis T

更新日期：1999-09-03 00:00:00

abstract：:Direct administration of interleukin-1beta (IL-1beta) into the lateral cerebral ventricle of rat brain, in addition to inducing febrile responses, upregulated the immunoreactivity of tryptophan hydroxylase in the preoptic anterior hypothalamus. The fever induced by IL-1beta was significantly attenuated by pretreatment...

journal_title：Neuroscience letters

authors： Chio CC,Tsai SM,Wang JJ,Lin MT

更新日期：2005-06-10 00:00:00

abstract：:The aim of the present study was to determine if pre-exposure to high doses of cocaine can subsequently alter the rewarding effects of this drug. Adult male mice received a pretreatment of physiological saline, or 12.5 or 25 mg/kg of cocaine (one injection a day for five days). After an interval of six days without in...

journal_title：Neuroscience letters

authors： Manzanedo C,García-Pardo MP,Rodríguez-Arias M,Miñarro J,Aguilar MA

更新日期：2012-05-10 00:00:00

abstract：:Because there are sex differences in feeding-related behavior and orexin neurons are involved in feeding, we looked for a possible sex difference in the response of orexin neurons in the lateral hypothalamic area to fasting, using the phosphorylated cyclic AMP response element-binding protein (pCREB) as a marker of ne...

journal_title：Neuroscience letters

authors： Funabashi T,Hagiwara H,Mogi K,Mitsushima D,Shinohara K,Kimura F

更新日期：2009-09-29 00:00:00

abstract：:Aquaporins are involved in the maintenance of ionic and osmotic balance in the central nervous system and in the eye. Whereas the expression of aquaporin-9 immunoreactivity in the brain has been described for catecholaminergic neurons and glial cells, the expression of aquaporin-9 in the neural retina is unclear. We e...

journal_title：Neuroscience letters

authors： Iandiev I,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2006-05-08 00:00:00

abstract：:NMDA and non-NMDA receptor-mediated components of excitatory post-synaptic current (EPSC) were studied by in situ whole-cell voltage-clamp recordings in the CA1 field of rat hippocampus. We found that the amplitudes ratio of the NMDA to the non-NMDA components can be strongly increased by blocking A1 adenosine recepto...

journal_title：Neuroscience letters

authors： Klishin A,Lozovaya N,Krishtal O

更新日期：1994-09-26 00:00:00

abstract：:The survival of developing sensory neurons is dependent upon target-derived growth factors, in their absence neurons undergo programmed cell death. The molecular mechanisms underpinning neuronal cell survival and death are poorly understood. Tyrosine kinases are important signalling proteins that have been implicated ...

journal_title：Neuroscience letters

authors： Bartlett SE

更新日期：1997-05-16 00:00:00

abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...

journal_title：Neuroscience letters

authors： Alvarez P,Levine JD,Green PG

更新日期：2015-03-30 00:00:00

abstract：:This report describes sensory reinnervation of muscle receptors in humans. In this study, sensory function was investigated in fourteen patients with brachial plexus injury, whose musculocutaneous nerve was surgically sutured with intercostal nerves for reconstruction of elbow flexion. Tapping the intercostal nerve-re...

journal_title：Neuroscience letters

authors： Kanamaru A,Suzuki S,Sibuya M,Homma I,Sai K,Hara T

更新日期：1993-10-14 00:00:00

abstract：:The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultu...

journal_title：Neuroscience letters

authors： Li RX,Yu XZ,Fu M,Zong M,Liu RL,Xie ZP

更新日期：2008-08-15 00:00:00

abstract：:A retrograde tracer, Diamidino yellow, was injected into the hindlimb region of the supplementary motor area after intracortical microstimulation mapping in the Japanese monkey. As a result, a cluster of retrogradely labeled neurons was found in the caudal bank of the arcuate sulcus, which corresponds to the ventral p...

journal_title：Neuroscience letters

authors： Tokuno H,Inase M

更新日期：1994-04-25 00:00:00

abstract：:Two patients with Xp21 muscular dystrophy Becker type showed absence of dystrophin in muscle biopsy tested with 4 antibodies (polyclonal anti-60 kDa, monoclonal against the rod domain, the C-terminus and the N-terminus). DNA analysis did not detect any deletion in one patient and demonstrated deletion of exons 3-7 in ...

journal_title：Neuroscience letters

authors： Mongini T,Palmucci L,Doriguzzi C,Chiadoò-Piat L,Restagno G

更新日期：1992-11-23 00:00:00

abstract：:Inflammatory responses have been shown to modulate the pattern and degree of ischemic injury. Previously, we demonstrated that intracorpus callosum microinjection of lipopolysaccharide (LPS, a well-known endotoxin) markedly induced inflammatory responses confined to ipsilateral hemisphere and aggravated cerebral ische...

journal_title：Neuroscience letters

authors： Cho GS,Lee JC,Ju C,Kim C,Kim WK

更新日期：2013-03-22 00:00:00

abstract：:The objective of the present study was to determine differences in neural networks between expert and novice archers during an archery pre-performance routine period (PPR). The experiment was conducted with eight world-class competitor or Olympic medalist archers and eight novices. In the experiment, the task was to s...

journal_title：Neuroscience letters

authors： Kim J,Lee HM,Kim WJ,Park HJ,Kim SW,Moon DH,Woo M,Tennant LK

更新日期：2008-11-21 00:00:00

abstract：:Previous studies have extensively reported an advantage of females in empathy as compared with males. It remains to be clarified, however, whether these sex differences are associated with sex specific neural processes underlying empathic response to different intensity of emotional stimulus. The present study examine...

journal_title：Neuroscience letters

authors： Luo P,Zheng X,Chen X,Li Y,Wang J,Deng L,Zheng X

更新日期：2014-08-22 00:00:00

abstract：:The dopamine system in the limbic-prefrontal cortex has been assumed to play an important role in the cognitive dysfunction of schizophrenia and phencyclidine (PCP)-induced psychosis. In the present study, the role of metabotropic glutamate (mGlu) receptor subtypes on PCP-induced cortical dopamine release was investig...

journal_title：Neuroscience letters

authors： Maeda J,Suhara T,Okauchi T,Semba J

更新日期：2003-01-23 00:00:00

abstract：:The expression of aquaporin-1 (AQP1) protein, a water channel, in the choroid plexus epithelium was examined in the rat to determine the role of AQP1 in the pathophysiology of systemic hyponatremia. Systemic hyponatremia was produced by coadministration of 30 ml hypotonic dextrose solution (140 mM) intraperitoneally a...

journal_title：Neuroscience letters

authors： Moon Y,Hong SJ,Shin D,Jung Y

更新日期：2006-02-27 00:00:00

abstract：:125I-Staphylococcal protein A was used to visualize immunoreactive cell antigen in rat brain and pituitary by autoradiography. Autoradiograms of rat brain sections generated with 125I-protein A were clear and showed low background signals. We were able to visualize neural structures containing tyrosine hydroxylase or ...

journal_title：Neuroscience letters

authors： Correa FM,Guilhaume SS,Saavedra JM

更新日期：1988-06-29 00:00:00

abstract：:Gap junctions between neurons contribute to synchronous neuronal firing and may play a role in the pathophysiology of epilepsy. We examined the expression of a number of gap junction subunits, including the neuronal gap junction forming protein connexin36 (Cx36), in the hippocampus at various time points following an ...

journal_title：Neuroscience letters

authors： McCracken CB,Roberts DC

更新日期：2006-09-11 00:00:00

abstract：:Intracellular recordings were used to examine the mechanisms underlying the 5-hydroxytryptamine (5-HT)4 receptor-mediated depolarization seen in CA1 region pyramidal cells in in vitro hippocampal brain slices. This depolarization was mimicked and occluded by administration of the membrane permeable cyclic adenosine mo...

journal_title：Neuroscience letters

authors： Chapin EM,Haj-Dahmane S,Torres G,Andrade R

更新日期：2002-05-10 00:00:00

abstract：:The effects of histamine (HA) on the resting membrane potential and input resistance of rat medial vestibular nucleus (MVN) neurons were investigated using intracellular recording techniques from a submerged brain slice preparation. The exogenous application of HA predominantly produced a concentration-dependent membr...

journal_title：Neuroscience letters

authors： Phelan KD,Nakamura J,Gallagher JP

更新日期：1990-02-16 00:00:00