Abstract:
OBJECTIVE:To investigate the protective effect of gliclazide and the role of dynamin-related protein l (Drp-1)-mediated oxidative stress and apoptosis in diabetic peripheral neuropathy (DPN). METHODS:Diabetic rats developed through intra-peritoneal injection of streptozotocin were randomly assigned to treatment group receiving gliclazide or non-treatment group without gliclazide treatment. Rats in control group received intra-peritoneal injection of vehicle and no gliclazide treatment. Eight weeks later, the nerve conduction velocity (NCV) of sciatic nerve was measured and the morphological alterations, the malondialdehyde (MDA) level and superoxide-dismutase (SOD) activity, the expressions of Drp-1, caspase-3, Bax and Bcl-2 in sciatic nerve were evaluated. RESULTS:When compared to rats in control group, rats in non-treatment group showed significantly decrease of NCV, obvious demyelinative alteration of sciatic nerve, increased expressions of Drp-1, caspase-3, Bax, Bcl-2 and MDA, and decreased SOD activity. Compared to rats in non-treatment group, rats in treatment group showed significantly increase of NCV, less demyelination of sciatic nerve, decreased expressions of Drp-1, caspase-3, Bax and MDA, and increased activity of SOD. The expression of Bcl-2 was not significantly different between treatment and non-treatment groups. CONCLUSION:Gliclazide showed protective effect on DPN through modulating Drp-1-mediated oxidative stress and apoptosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wu YB,Shi LL,Wu YJ,Xu WH,Wang L,Ren MSdoi
10.1016/j.neulet.2012.06.038subject
Has Abstractpub_date
2012-08-08 00:00:00pages
45-9issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(12)00846-4journal_volume
523pub_type
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