Cooling of the nucleus raphe dorsalis induces sleep in the cat.

Abstract:

:Localized moderate cooling (+10 degrees C) of the anterior and ventral part of the raphe dorsalis induced cortical synchronization and ponto-geniculo-occipital (PGO) waves followed sometimes by paradoxical sleep. Cooling the region of the raphe magnus produced cortical arousal. After depletion of brain 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine, cooling the raphe dorsalis resulted in muscle atonia and bursts of high frequency PGO waves but not in cortical synchronization. Following restoration of brain 5-HT by intravenous administration of 5-hydroxytryptophan, cooling again produced cortical synchronization and PGO waves as in the control experiments, but with a diminishing efficacy during repetitive cooling episodes.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cespuglio R,Walker E,Gomez ME,Musolino R

doi

10.1016/0304-3940(76)90077-x

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

221-7

issue

4

eissn

0304-3940

issn

1872-7972

pii

0304-3940(76)90077-X

journal_volume

3

pub_type

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