Evidence for the neuronal origin of immunoreactive interleukin-1 beta released by rat hypothalamic explants.

abstract：:Spinal motor neurones in the adult mouse were labelled retrogradely with both True Blue and horseradish peroxidase (HRP). Using the cell sorter, motor neurones were separated on the basis of cell size and the intensity of True Blue fluorescence. Cultures of the sorted cells were then prepared and the motor neurones we...

journal_title：Neuroscience letters

authors： Eagleson KL,Bennett MR

更新日期：1983-07-29 00:00:00

abstract：:Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area. This protein has been reported to interact specifically with the C-termini of AMPA-selective glutamate receptor channel subunits, GluRalpha2 and GluRalpha3 through i...

journal_title：Neuroscience letters

authors： Yamazaki M,Fukaya M,Abe M,Ikeno K,Kakizaki T,Watanabe M,Sakimura K

更新日期：2001-05-18 00:00:00

abstract：:Effects of near-ultraviolet (UV-A; 325-390 nm, peak at 365 nm) light on the activity of the pineal serotonin N-acetyltransferase (NAT; a penultimate and key regulatory enzyme in melatonin biosynthesis) were examined in rats. Acute exposure of dark-adapted animals to UV-A radiation produced a marked suppression of NAT ...

journal_title：Neuroscience letters

authors： Zawilska JB,Rosiak J,Nowak JZ

更新日期：1998-02-27 00:00:00

abstract：:2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and can...

journal_title：Neuroscience letters

authors： Park M,Song KS,Kim HK,Park YJ,Kim HS,Bae MI,Lee J

更新日期：2009-01-16 00:00:00

abstract：:In this study, we investigated the role of nitric oxide (NO) in neuronal cell death in the lipopolysaccharide (LPS)-treated rat hippocampal slice culture. Neuronal cell death was induced after a LPS treatment in a rat hippocampal slice. The region and time course of the cell death caused by LPS were different from tho...

journal_title：Neuroscience letters

authors： Lee P,Son D,Lee J,Kim YS,Kim H,Kim SY

更新日期：2003-09-25 00:00:00

abstract：:Gastrin-releasing peptide (GRP) was demonstrated by immunohistochemistry and high-performance liquid chromatography to be present in the great majority of neurons in the geniculate ganglion of rat and man. This was in contrast to findings in the sphenopalatine ganglion of rat, where only little GRP was found, and in t...

journal_title：Neuroscience letters

authors： Hardebo JE,Suzuki N,Ekman R

更新日期：1992-05-25 00:00:00

abstract：:Dopamine-derived 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, released an enormous amount of serotonin in the rat striatum; the concentration of serotonin increased from undetectable level to 2.53 +/- 0.12 and 3.69 +/- 0.01 microM after perfusion of (R)- and (S)salsolinol, respective...

journal_title：Neuroscience letters

authors： Maruyama W,Nakahara D,Dostert P,Hashiguchi H,Ohta S,Hirobe M,Takahashi A,Nagatsu T,Naoi M

更新日期：1993-01-12 00:00:00

abstract：:Four substance P (SP) antagonists were tested on anaesthetized rats, by injecting 8 microgram amounts into the spinal cord (T8-T9), and by observing their effects on the hypothalamo-neurohypophysial responses to a presumably painful stimulus, the superfusion of the hepatic portal vein with 1 microM bradykinin. Only tw...

journal_title：Neuroscience letters

authors： Stoppini L,Baertschi AJ,Mathison R,Barja F

更新日期：1983-06-30 00:00:00

abstract：:Recent imaging studies have reported the projection of semicircular canal signals onto wide regions of the cerebral cortex but little is known about otolith projections onto the cerebral cortex. We used functional magnetic resonance imaging (fMRI) to investigate the activation of the cortex by loud clicks that selecti...

journal_title：Neuroscience letters

authors： Miyamoto T,Fukushima K,Takada T,de Waele C,Vidal PP

更新日期：2007-08-09 00:00:00

abstract：:Isolated Helix neurons were internally perfused under voltage-clamp, with drugs applied by the 'concentration clamp' which allowed an extremely rapid switching of the external solution. 4-Aminopyridine (4-AP) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine. Acetylcho...

journal_title：Neuroscience letters

authors： Ikemoto Y,Akaike N,Ono K

更新日期：1987-04-23 00:00:00

abstract：:On the basis of the recent cloning of the beta-secretase, the beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE), (Science, 286 (1999) 735), digoxigenin-labelled riboprobes were generated to localize the cellular expression pattern of BACE mRNA in brain sections of transgenic Tg2576 mice, overexpressing ...

journal_title：Neuroscience letters

authors： Bigl M,Apelt J,Luschekina EA,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2000-10-06 00:00:00

abstract：:One of the clinical characteristics of psychogenic tremors (PT) is the disruption or transient cessation of tremor with distractive manoeuvres, including those involving the performance of voluntary movements with the contralateral hand. Seven patients with PT, 11 patients with Parkinson's disease (PD), 10 patients wi...

journal_title：Neuroscience letters

authors： Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Sanegre MT,Tolosa E

更新日期：2004-11-11 00:00:00

abstract：:The structure of CACNA1G, the gene encoding alpha1G, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66490 basepairs of chromosome 1...

journal_title：Neuroscience letters

authors： Mittman S,Guo J,Agnew WS

更新日期：1999-10-29 00:00:00

abstract：:Although abnormal processing of amyloid precursor protein (APP) leads to early onset of Alzheimer's disease, the normal function of this protein is poorly understood. APP is widely expressed in axons, dendrites, and synapses in both central and peripheral nervous systems. Mice homozygous for APP or its homologue APP-l...

journal_title：Neuroscience letters

authors： Yang G,Gong YD,Gong K,Jiang WL,Kwon E,Wang P,Zheng H,Zhang XF,Gan WB,Zhao NM

更新日期：2005-08-12 00:00:00

abstract：:A possible role of the human cerebellum in the generation of verbs corresponding to presented nouns has been suggested. Previous functional brain imaging studies have compared generation of verbs with the reading of nouns as a measure of verb generation. In the present fMRI study involving healthy human subjects, the ...

journal_title：Neuroscience letters

authors： Frings M,Dimitrova A,Schorn CF,Elles HG,Hein-Kropp C,Gizewski ER,Diener HC,Timmann D

更新日期：2006-11-27 00:00:00

abstract：:Magnetic resonance imaging was used to investigate the relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric measurements for the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) and prefrontal sub-regions (the superior frontal gyrus, middl...

journal_title：Neuroscience letters

authors： Takahashi T,Suzuki M,Tsunoda M,Kawamura Y,Takahashi N,Tsuneki H,Kawasaki Y,Zhou SY,Kobayashi S,Sasaoka T,Seto H,Kurachi M,Ozaki N

更新日期：2008-04-11 00:00:00

abstract：:Serotonin (5-HT) has been implicated in the regulation of circadian rhythms through its actions on the suprachiasmatic nucleus (SCN). Recent data suggests that, along with excitatory amino acids, serotonin may be important in the neural pathway that mediates the transmission of photic information to the circadian syst...

journal_title：Neuroscience letters

authors： Moyer RW,Kennaway DJ

更新日期：1999-08-27 00:00:00

abstract：:8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5 mg/kg) alone or co-admi...

journal_title：Neuroscience letters

authors： Yelleswarapu NK,Tay JK,Fryer WM,Shah MA,Garcia AN,Cheng JP,Kline AE

更新日期：2012-05-02 00:00:00

abstract：:Dopamine metabolism and release were determined in the striata of rats sustaining varying damage to the nigrostriatal dopamine (DA) projection. DA metabolism, inferred from concentrations of dihydroxy-phenylacetic acid (DOPAC) or homovanillic acid (HVA), decreased with DA denervation of more than 20%. Dopamine release...

journal_title：Neuroscience letters

authors： Altar CA,Marien MR

更新日期：1989-01-30 00:00:00

abstract：BACKGROUND:Animal and neuroimaging studies suggest that the volume of the motor-circuit region decreases in tardive dyskinesia (TD). This study examined the differences in functional connectivity within the motor circuit of patients with schizophrenia with and without TD to further clarify how the dysfunction is relate...

journal_title：Neuroscience letters

authors： Yu T,Li Y,Li N,Huang J,Fan F,Luo X,Tan S,Yang F,Tian B,Tian L,Elliot Hong L,Tan Y

更新日期：2021-01-18 00:00:00

abstract：:Prevention of beta-amyloid (Abeta) production, aggregation and formation of Abeta deposits is a key pharmacological target in Alzheimer's disease. The passage of Abeta-binding compounds through the blood-brain barrier is often hampered for free ligands, whereas it is enhanced by drug encapsulation in nanoparticles. He...

journal_title：Neuroscience letters

authors： Härtig W,Paulke BR,Varga C,Seeger J,Harkany T,Kacza J

更新日期：2003-02-27 00:00:00

abstract：:Using a reproducible two-vessel occlusion model for forebrain ischemia in rats, we investigated the temporal and spatial changes of vascular endothelial growth factor (VEGF) expression after transient forebrain ischemia with Northern blot analysis and in situ hybridization. Northern blot analysis revealed that VEGF mR...

journal_title：Neuroscience letters

authors： Lee MY,Ju WK,Cha JH,Son BC,Chun MH,Kang JK,Park CK

更新日期：1999-04-16 00:00:00

abstract：:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer drug. One obstacle in TRAIL-based therapies is that many cancer cells, including gliomas, are resistant towards TRAIL. In this study one glioblastoma cell line, one human short-term glioblastoma culture and human astrocytes were tre...

journal_title：Neuroscience letters

authors： Siegelin MD,Siegelin Y,Habel A,Gaiser T

更新日期：2009-04-03 00:00:00

abstract：:The purpose of this study was to investigate how the recruitment gain, as derived from the Hoffmann (H)-reflex measurement, of antagonistic motoneurons is modulated during voluntary lengthening (LEN) and shortening (SHO) contractions in the human tibialis anterior (TA) muscle. To this end, the parameters of the ratios...

journal_title：Neuroscience letters

authors： Sekiguchi H,Nakazawa K,Akai M

更新日期：2003-05-15 00:00:00

abstract：:The effect of the metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) was investigated on the induction of long-term potentiation (LTP) of alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate receptor-mediated excitatory postsynaptic currents (epscs) recorded from denta...

journal_title：Neuroscience letters

authors： Wang Y,Rowan MJ,Anwyl R

更新日期：1995-09-15 00:00:00

abstract：:A restricted recovery of visual excitation occurs in the partially deafferented dorsal lateral geniculate nucleus (dLGN) of the cat after retinal lesions. In the absence of axonal growth an increase of retinogeniculate synapses at the peripheral dendrites of deafferented cells could be a possible underlying mechanism....

journal_title：Neuroscience letters

authors： Eysel UT,Neubacher U

更新日期：1984-08-24 00:00:00

abstract：:Several evidences indicate that PPARgamma stimulation promotes neuronal differentiation. However, to date, no data describe the effects of PPARgamma agonists on neurite outgrowth. Here we have evaluated the effects of pioglitazone, a synthetic PPARgamma agonist, on differentiation and neurite outgrowth in SH-SY5Y huma...

journal_title：Neuroscience letters

authors： Miglio G,Rattazzi L,Rosa AC,Fantozzi R

更新日期：2009-04-24 00:00:00

abstract：:In freely moving rats, effects of unilateral haloperidol injection into the substantia nigra were monitored with in vivo voltammetry in the bilateral striata. The electrochemical responses at 120 mV versus Ag-AgCl, reflecting mainly a level of 3,4-dihydroxyphenylacetic acid (DOPAC), increased both in the striata withi...

journal_title：Neuroscience letters

authors： Kato T,Ishii K,Ikeda M

更新日期：1984-09-07 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:Although first mentions about calcium disturbances in psychiatric diseases appeared more than 30 years ago, the most recent genomic and proteomic findings confirmed a significant role of Ca2+ and Ca2+-regulated pathways in development of neuropathological processes, including bipolar disorder and schizophrenia. Moreov...

journal_title：Neuroscience letters

authors： Lisek M,Boczek T,Zylinska L

更新日期：2018-01-10 00:00:00