Preservation of dopamine release in the denervated striatum.

Abstract:

:Dopamine metabolism and release were determined in the striata of rats sustaining varying damage to the nigrostriatal dopamine (DA) projection. DA metabolism, inferred from concentrations of dihydroxy-phenylacetic acid (DOPAC) or homovanillic acid (HVA), decreased with DA denervation of more than 20%. Dopamine release, inferred from the concentration of 3-methoxytyramine (3-MT), did not decrease unless the denervation was at least 80%. The amount of 3-MT per surviving neuron exceeded that for DOPAC over most of the denervation range. Thus, striatal DA release is preserved at normal levels with the survival of only 20% of the striatal DA innervation. Decreases in DA release, rather than decreases in DA metabolism or the density of dopamine innervation, coincide with the appearance of behavioral impairments.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Altar CA,Marien MR

doi

10.1016/0304-3940(89)90400-x

subject

Has Abstract

pub_date

1989-01-30 00:00:00

pages

329-34

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90400-X

journal_volume

96

pub_type

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