Abstract:
:NGP1-01, a member of the pentacycloundecylamine cage compound family, was recently shown to exhibit both NMDA receptor channel blocking and L-type calcium channel antagonism activity. In the present study, focal ischemia was induced in mice by permanent middle cerebral artery occlusion (MCAO) to test for potential neuroprotective properties of the compound. In female CD-1 mice injected 30 min before MCAO, NGP1-01 (20 mg/kg) reduced infarct area by 42.6% (P < 0.05) compared to vehicle-treated controls as visualized by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Concomitantly, NGP1-01 reduced brain swelling by 78.3% (P < 0.001), compared to vehicle (DMSO) treated controls. These data identify NGP1-01 and related compounds as potential lead structures to develop neuroprotective compounds based on a dual mechanism of action.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mdzinarishvili A,Geldenhuys WJ,Abbruscato TJ,Bickel U,Klein J,Van der Schyf CJdoi
10.1016/j.neulet.2005.03.042keywords:
subject
Has Abstractpub_date
2005-07-22 00:00:00pages
49-53issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00337-Xjournal_volume
383pub_type
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