Abstract:
:Serial sections of human brainstem were used to determine the total number of pigmented cells in locus coeruleus and, by immunohistochemical staining using an antiserum directed against human dopamine-beta-hydroxylase (DBH), the number of DBH-positive cells. In 12 brains from elderly control and dementia subjects there wer not significant differences in the total cell populations determined in the same brain by the two techniques. In 6 patients with senile dementia of Alzheimer's type there was a variable loss (average about 60% reduction) in locus coeruleus cells when compared to controls of similar age. The loss of noradrenergic neurones from locus coeruleus was accompanied by an average reduction of similar magnitude in noradrenaline concentration in temporal cortex, with no change or an increase in dopamine content. There was also a significant reduction in the cholinergic marker choline acetyltransferase in cortex samples from the dementia cases.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Iversen LL,Rossor MN,Reynolds GP,Hills R,Roth M,Mountjoy CQ,Foote SL,Morrison JH,Bloom FEdoi
10.1016/0304-3940(83)90171-4subject
Has Abstractpub_date
1983-08-19 00:00:00pages
95-100issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(83)90171-4journal_volume
39pub_type
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