Abstract:
:Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested, labeled with monoclonal antibodies, and analyzed by flow cytometry. Positive markers included CD9, CD15, CD81, CD95 (Fas), GD(2) ganglioside, and major histocompatibility complex class I and beta2 microglobulin, as well as low levels of the hematopoietic stem cell marker CD34. Of these, mouse NPCs were positive for CD9, CD15, CD81, and GD(2) ganglioside. The markers reported here have been implicated in a wide range of cellular functions including proliferation, migration, differentiation, apoptosis, and immune recognition.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Klassen H,Schwartz MR,Bailey AH,Young MJdoi
10.1016/s0304-3940(01)02215-7keywords:
subject
Has Abstractpub_date
2001-10-26 00:00:00pages
180-2issue
3eissn
0304-3940issn
1872-7972pii
S0304394001022157journal_volume
312pub_type
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