Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes.

Abstract:

:Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested, labeled with monoclonal antibodies, and analyzed by flow cytometry. Positive markers included CD9, CD15, CD81, CD95 (Fas), GD(2) ganglioside, and major histocompatibility complex class I and beta2 microglobulin, as well as low levels of the hematopoietic stem cell marker CD34. Of these, mouse NPCs were positive for CD9, CD15, CD81, and GD(2) ganglioside. The markers reported here have been implicated in a wide range of cellular functions including proliferation, migration, differentiation, apoptosis, and immune recognition.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Klassen H,Schwartz MR,Bailey AH,Young MJ

doi

10.1016/s0304-3940(01)02215-7

keywords:

subject

Has Abstract

pub_date

2001-10-26 00:00:00

pages

180-2

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394001022157

journal_volume

312

pub_type

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