Glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes are increased in the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice.

Abstract:

:In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocytes are increased. The usual ordered array of tanycytic processes is obscured by a tangle of GFAP-stained stellate glial cells. GFAP immunostaining in other regions of the Tfm forebrain is similar to that in normal mice. These results suggest that the distribution of reactive glia in the hypothalamus may have been changed as a consequence of the genetic defect in Tfm mice.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

McQueen JK,Wright AK,Arbuthnott GW,Fink G

doi

10.1016/0304-3940(90)90252-5

subject

Has Abstract

pub_date

1990-10-02 00:00:00

pages

77-81

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90252-5

journal_volume

118

pub_type

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