Abstract:
:In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocytes are increased. The usual ordered array of tanycytic processes is obscured by a tangle of GFAP-stained stellate glial cells. GFAP immunostaining in other regions of the Tfm forebrain is similar to that in normal mice. These results suggest that the distribution of reactive glia in the hypothalamus may have been changed as a consequence of the genetic defect in Tfm mice.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
McQueen JK,Wright AK,Arbuthnott GW,Fink Gdoi
10.1016/0304-3940(90)90252-5subject
Has Abstractpub_date
1990-10-02 00:00:00pages
77-81issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(90)90252-5journal_volume
118pub_type
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