Abstract:
:P2Y(1) is probably an important subtype of purinergic receptors (P2Rs) in modulation of the astrocyte activation in spinal cord. The aim of this study was to observe the effect of P2Y(1) receptor on the abnormal energy metabolism of the cultured rat spinal astrocyte induced by extracellular adenosine diphosphate (ADP). The results showed that adenosine triphosphate (ATP) and mitochondrial membrane potential (MMP) in the astrocytes were up-regulated in the presence of ADP, which could be enhanced by MRS2179, a specific antagonist for P2Y(1) receptor. A higher level of expression of the AMP-activated protein kinase (AMPK) was found in the presence of MRS2179 and ADP together than that ADP alone. Blocking of AMPK with Compound C could effectively inhibit the enhancing effect of MRS2179 on ADP-induced astrocyte proliferation and ATP accumulation. Our results suggested that the P2Y(1) receptor mediated inhibition of AMPK may help to prevent the astrocytes from over activation induced by extracellular ADP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cui J,Ou S,He WJ,Du L,Zhao YD,Ruan HZdoi
10.1016/j.neulet.2011.08.045subject
Has Abstractpub_date
2011-10-10 00:00:00pages
244-9issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(11)01230-4journal_volume
503pub_type
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