Nitric oxide synthase inhibitors L-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced excitotoxicity.

abstract：:We studied anxiety-like behavior in the elevated plus-maze (EPM) tests in male Lewis rats on days 2 and 4 of adjuvant arthritis (AA). In plasma we analyzed C-reactive protein (CRP), albumin, ACTH, corticosterone, in the hippocampus the mRNA expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), corticotrophin rel...

journal_title：Neuroscience letters

authors： Skurlova M,Stofkova A,Jurcovicova J

更新日期：2011-01-07 00:00:00

abstract：:Projections of neurones in Forel's field H (FFH) to the upper cervical cord and to the lower brainstem were demonstrated by retrograde labelling of the neurones with horseradish peroxidase (HRP). Systematic threshold mapping for evoking antidromic spikes of FFH neurones revealed that they projected to the neck motor n...

journal_title：Neuroscience letters

authors： Isa T,Itouji T,Sasaki S

更新日期：1988-07-19 00:00:00

abstract：:Many studies have shown that minocycline, an antibacterial tetracycline, suppresses experimental pain. While minocycline's positive effects on pain resolution suggest that clinical use of such drugs may prove beneficial, minocycline's antibiotic actions and divalent cation (Ca(2+); Mg(2+)) chelating effects detract fr...

journal_title：Neuroscience letters

authors： Bastos LF,Godin AM,Zhang Y,Jarussophon S,Ferreira BC,Machado RR,Maier SF,Konishi Y,de Freitas RP,Fiebich BL,Watkins LR,Coelho MM,Moraes MF

更新日期：2013-05-24 00:00:00

abstract：:We have identified the secretory cleavage site in the Alzheimer amyloid precursor (APP) in a non-transfected neuronal cell line, using cyanogen bromide digests of APP purified from medium conditioned by PC-12 cells which were differentiated to a neuronal phenotype. The results obtained are most consistent with proteol...

journal_title：Neuroscience letters

authors： Anderson JP,Esch FS,Keim PS,Sambamurti K,Lieberburg I,Robakis NK

更新日期：1991-07-08 00:00:00

abstract：:Oestrogen influences both oxytocin mRNA and peptide immunoreactivity in the preoptic area and the rat oxytocin gene contains functional oestrogen response elements. However, using combinations of immunocytochemistry and in situ hybridization for oxytocin and oestrogen receptor, we found that preoptic oxytocin neurons ...

journal_title：Neuroscience letters

authors： Cruttwell CJ,Herbison AE,Bicknell RJ

更新日期：1995-11-17 00:00:00

abstract：PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...

journal_title：Neuroscience letters

authors： Wang Y,Zhou S,Han Z,Yin D,Luo Y,Tian Y,Wang Z,Zhang J

更新日期：2020-09-25 00:00:00

abstract：:Tau in cerebrospinal fluid (CSF) has been proposed as a diagnostic marker for Alzheimer's disease (AD). This paper presents a new sensitive sandwich ELISA allowing quantitation of tau from 8 microl CSF/well. A human specific monoclonal tau antibody HT7 was used as a capture antibody and a mixture of polyclonal tau ant...

journal_title：Neuroscience letters

authors： Yamamori H,Khatoon S,Grundke-Iqbal I,Blennow K,Ewers M,Hampel H,Iqbal K

更新日期：2007-05-17 00:00:00

abstract：:In the adult, the dickkopf family member Dickkopf-like1 (Dkkl1) has been described as a testicular protein involved in the regulation of spermatocyte apoptosis. However, microarray studies additionally suggested that Dkkl1 regulation is involved in various tumors including high grade gliomas. Since investigations of D...

journal_title：Neuroscience letters

authors： Sibbe M,Jarowyj J

更新日期：2013-02-22 00:00:00

abstract：:The effect of chronic salt loading on urocortin-like immunoreactivity (Ucn-IR) was investigated in the rat hypothalamo-neurohypophysial system. In control rats a few Ucn-IR neurons were observed scattered throughout the supraoptic nucleus (SON) and few in the paraventricular nucleus (PVN). A small number of Ucn-IR fib...

journal_title：Neuroscience letters

authors： Hara Y,Ueta Y,Isse T,Kabashima N,Shibuya I,Hattori Y,Yamashita H

更新日期：1997-05-16 00:00:00

abstract：:The aims of the present work were to evaluate the exploratory activity in Sprague-Dawley rats, as well as to analyze the nigral and striatal mRNA expression of the plasticity-related genes bdnf and arc after L-buthionine sulfoximine (BSO) injection into substantia nigra compacta. Lesioned rats traveled less distance i...

journal_title：Neuroscience letters

authors： Díaz-Hung ML,Ruiz-Fuentes JL,Díaz-García A,León-Martínez R,Alberti-Amador E,Pavón-Fuentes N,Blanco-Lezcano L

更新日期：2018-11-20 00:00:00

abstract：:Excitatory amino acids (EAAs) have been implicated in the pathophysiology of cellular injury after brain ischemia. Changes in extracellular levels of amino acids in rat cerebral cortex after permanent proximal middle cerebral artery (MCA) occlusion were examined using microdialysis. Significant increases were found in...

journal_title：Neuroscience letters

authors： Graham SH,Shiraishi K,Panter SS,Simon RP,Faden AI

更新日期：1990-03-02 00:00:00

abstract：:The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potential...

journal_title：Neuroscience letters

authors： Lambert NA,Levitin M,Harrison NL

更新日期：1992-02-03 00:00:00

abstract：:Thioredoxin (TRX) is a small, multifunctional protein with a redox-active site and multiple biological functions that include reducing activity for reactive oxygen intermediates. We assayed TRX by immunohistochemical methods in the rat brain after intraperitoneal injection of 3-nitropropionic acid (3-NP), an irreversi...

journal_title：Neuroscience letters

authors： Sugino T,Nozaki K,Takagi Y,Hattori I,Hashimoto N,Yodoi J

更新日期：1999-11-12 00:00:00

abstract：:We hypothesized that neuropeptides released from the peripheral terminals of primary afferents play an important role in mechanical hyperalgesia after peripheral nerve injury. Nerve injury was performed on rats with lumbar 5 spinal nerve lesion (L5 SNL), which was preceded by L5 dorsal rhizotomy (L5 DR) to avoid the p...

journal_title：Neuroscience letters

authors： Jang JH,Nam TS,Paik KS,Leem JW

更新日期：2004-04-29 00:00:00

abstract：:The normal development of the superior collicular map of auditory space in the guinea pig requires visual experience (Eur. J. Neurosci., 2 (1990) 682-692). The possible role of the visual cortex in this process was assessed by unilateral removal of the cortex prior to the crucial period during which visual experience ...

journal_title：Neuroscience letters

authors： Withington DJ,Binns KE,Keating MJ

更新日期：1991-04-29 00:00:00

abstract：:After systemic administration of the dopamine agonist apomorphine (APO) in common toads Bufo bufo spinosus, the excitatory receptive fields of retinal R2 and R3 ganglion cells doubled their size and the response activities of these neurons to moving visual stimuli were generally increased. Comparable investigations of...

journal_title：Neuroscience letters

authors： Glagow M,Ewert JP

更新日期：1994-05-23 00:00:00

abstract：:Cocaine administration has been shown to affect several sites in the limbic forebrain. The nucleus accumbens has been implicated as an important site for the reinforcing aspects of this drug whereas, the amygdala and hippocampus may be more involved in drug conditioning and/or drug induced changes in the perception of...

journal_title：Neuroscience letters

authors： Robledo P,Kaneko WM,Ehlers CL

更新日期：1993-09-17 00:00:00

abstract：:To study the spatial frequency (SF) effects on cortical face processing, we recorded magnetoencephalographic responses in seven healthy subjects to upright and inverted human faces. Four face types were used, including original (broad-band SF, BSF), low SF (LSF, <5 cycles/face), middle SF (MSF, 5-15 cycles/face), and ...

journal_title：Neuroscience letters

authors： Hsiao FJ,Hsieh JC,Lin YY,Chang Y

更新日期：2005-05-20 00:00:00

abstract：:Guanidine, the active ingredient extracted from Galega officinalis, is introduced as a ligand for imidazoline I2 receptor (I2R) because guanidine decreased plasma glucose via an activation of I2BR to increase glucose uptake into skeletal muscle isolated from Wistar rats. However, the signals for this action of guanidi...

journal_title：Neuroscience letters

authors： Lui TN,Tsao CW,Huang SY,Chang CH,Cheng JT

更新日期：2010-05-03 00:00:00

abstract：:The mesencephalic trigeminal nucleus contains cell bodies of primary somatic sensory neurons that innervate the head region. The neurons resemble dorsal root ganglion cells but a striking difference is the presence of synaptic boutons in the nucleus. The present report demonstrates with anterograde tracers, the existe...

journal_title：Neuroscience letters

authors： Buisseret-Delmas C,Pinganaud G,Compoint C,Buisseret P

更新日期：1997-07-04 00:00:00

abstract：:In the present study, the effects of fluvoxamine on the inhibition of gastrointestinal transit, antinociception and hyperlocomotion induced by morphine were investigated in mice. Treatment with morphine (10 mg/kg, subcutaneously (s.c.)) inhibited gastrointestinal transit and hyperlocomotion. These effects were attenua...

journal_title：Neuroscience letters

authors： Ise Y,Katayama S,Hirano M,Aoki T,Narita M,Suzuki T

更新日期：2001-02-16 00:00:00

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:gamma-Aminobutyric acid (GABA)-mediated neurotransmission from the granule cells to CA3 is transiently expressed during the first 3 weeks of age in the rat. In the adult, seizures provoke this inhibitory signaling to reappear. To gain insight into the origin of GABA in these cells, we explored the expression of both i...

journal_title：Neuroscience letters

authors： Maqueda J,Ramírez M,Lamas M,Gutiérrez R

更新日期：2003-12-15 00:00:00

abstract：:Interleukin-6 (IL-6) has been shown to have potent neurotrophic activity on peripheral and central neurons in vitro. However, it remains to be determined whether or not IL-6 rescues hippocampal CA1 neurons from lethal ischemia and prevents ischemia-induced learning disability. In the present in vivo study, we infused ...

journal_title：Neuroscience letters

authors： Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

更新日期：1996-02-02 00:00:00

abstract：:Neural stem cells (NSCs) persist in the mammalian brain throughout life and protect against hypoxia-ischemia injury. NSCs are being increasingly recognized as a novel therapeutic target for various neurological disorders. Previous research indicates that miR-21 attenuates hypoxia-ischemia induced apoptotic death in va...

journal_title：Neuroscience letters

authors： Chen R,Tai Y,Zhang Y,Wang L,Yang Y,Yang N,Ma S,Xue F,Wang J

更新日期：2019-01-18 00:00:00

abstract：:We have recently reported fluctuations in the expression of the period repeat sequence (pp2.5) during light-dark cycles in the suprachiasmatic nucleus (SCN) of rat [Neurosci. Lett., 122 (1991) 113-116]. Presently, we performed in situ hybridization which shows that the fluctuation of pp2.5 expression continues during ...

journal_title：Neuroscience letters

authors： Matsui M,Mitsui Y,Ishida N

更新日期：1993-12-12 00:00:00

abstract：:A dose-dependent loss of vanilloid receptors (specific [3H]resiniferatoxin binding sites) was found in sensory ganglia of rats 24 h after s.c. administration of resiniferatoxin (RTX), an ultrapotent capsaicin analog. This receptor loss displayed an ED50 of 30 micrograms/kg both in dorsal root and trigeminal ganglia; t...

journal_title：Neuroscience letters

authors： Szallasi A,Blumberg PM

更新日期：1992-06-08 00:00:00

abstract：:Hexokinase is known as the first enzyme and rate-limiting step in glycolysis. The role of hexokinase activity and localization in regulating the rate of axonal regeneration was studied in cultured adult sensory neurons of dorsal root ganglia (DRG). Immunofluorescent staining of DRG demonstrated that small-medium neuro...

journal_title：Neuroscience letters

authors： Wang Z,Gardiner NJ,Fernyhough P

更新日期：2008-03-21 00:00:00

abstract：:Acute physical exercise (APE) induces an increase in the individual alpha peak frequency (iAPF), a cortical parameter associated with neural information processing speed. The aim of this study was to further scrutinize the influence of different APE intensities on post-exercise iAPF as well as its time course after ex...

journal_title：Neuroscience letters

authors： Gutmann B,Zimmer P,Hülsdünker T,Lefebvre J,Binnebößel S,Oberste M,Bloch W,Strüder HK,Mierau A

更新日期：2018-03-06 00:00:00

abstract：:Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell ...

journal_title：Neuroscience letters

authors： Surmeier DJ,Bargas J,Kitai ST

更新日期：1989-09-11 00:00:00