Abstract:
:Four substance P (SP) antagonists were tested on anaesthetized rats, by injecting 8 microgram amounts into the spinal cord (T8-T9), and by observing their effects on the hypothalamo-neurohypophysial responses to a presumably painful stimulus, the superfusion of the hepatic portal vein with 1 microM bradykinin. Only two antagonists, the new D-Pro4,D-Trp7,9,10,Val8-SP4-11 and D-Pro4,D-Trp7,9,10-SP4-11 were capable of inhibiting the responses by 50-60%, the former compound having 3 times less agonistic activity. The results suggest that substitution of the aromatic phenylalanine by the non-polar valine in position 8 may significantly improve the overall characteristics of neurally active SP antagonists.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Stoppini L,Baertschi AJ,Mathison R,Barja Fdoi
10.1016/0304-3940(83)90444-5subject
Has Abstractpub_date
1983-06-30 00:00:00pages
279-83issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(83)90444-5journal_volume
37pub_type
杂志文章abstract::An optimized clinical functional magnetic resonance imaging (fMRI) protocol with a total scanning time of 8 min is presented that localizes Broca's and Wernicke's areas robustly and determines hemispheric dominance. Language function was visualized using two different sentence generation (SG) and word generation (WG) ...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2003-07-31 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11524-z
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journal_title:Neuroscience letters
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更新日期:1998-05-29 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1992-06-08 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01645-1
更新日期:2000-12-22 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90504-1
更新日期:1989-03-27 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90532-x
更新日期:1991-05-27 00:00:00
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更新日期:2002-08-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
abstract::Alterations of 'peripheral-type' benzodiazepine receptors (PTBRs) in brain are a feature of hepatic encephalopathy (HE). Although ammonia toxicity has been implicated in the disorder, recent findings suggest an accumulation of manganese in the brains of cirrhotic patients dying in hepatic coma. In this study, we exami...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00489-9
更新日期:1999-08-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90391-5
更新日期:1986-06-18 00:00:00
abstract::Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed ...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90036-x
更新日期:1987-01-02 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.06.010
更新日期:2005-10-28 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90196-1
更新日期:1994-11-21 00:00:00
abstract::Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90541-0
更新日期:1986-12-23 00:00:00
abstract::A Golgi-Cox, cresyl violet, and histofluorescence study has revealed the presence of dendrite bundles in nuclei raphe dorsalis (NRD) and centralis superior (NCS) in the rabbit brain stem. In NRD, bundles were found in the midline, traversing the medial longitudinal fasciculus (MLF) and in a circumferential location ar...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90010-5
更新日期:1980-03-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90442-8
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更新日期:1976-07-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2008-06-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.05.042
更新日期:2007-07-05 00:00:00
abstract::Sapogenins from Anemarrhenae asphodeloides was reported to improve the learning and memory abilities. In this study, we investigated the effect of Timosaponin B-II(TB-II), a purified extract from A. asphodeloidesb on rat vascular dementia (VD) produced by transient (2h) middle cerebral artery occlusion. The learning a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.04.082
更新日期:2007-06-27 00:00:00
abstract:OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.04.043
更新日期:2016-05-27 00:00:00
abstract::The present study aimed at investigating the effects of an artificial head position-based tongue-placed electrotactile biofeedback on postural control during quiet standing under different somatosensory conditions from the support surface. Eight young healthy adults were asked to stand as immobile as possible with the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.11.049
更新日期:2008-02-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90002-6
更新日期:1980-03-01 00:00:00
abstract::The effect of 4-aminopyridine (4-AP) on long-term potentiation (LTP) was studied in the hippocampal slice preparation of the rat. Field excitatory postsynaptic potentials (EPSPs) were recorded and evoked in the stratum radiatum of the CA1. Both the low frequency EPSP and LTP of the EPSP were significantly increased by...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90446-5
更新日期:1986-09-25 00:00:00
abstract::Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this fam...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)13290-0
更新日期:1997-01-17 00:00:00
abstract::Reflex responses of adrenal sympathetic nerve activity to stimulation of baroreceptor and cutaneous mechanoreceptors were compared in young adult (4 months old) and aged (26 months old) rats, under strictly controlled conditions for anesthesia, respiration and body temperature. Under these conditions the reflex depres...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90585-4
更新日期:1987-06-15 00:00:00