Abstract:
:The effect of 4-aminopyridine (4-AP) on long-term potentiation (LTP) was studied in the hippocampal slice preparation of the rat. Field excitatory postsynaptic potentials (EPSPs) were recorded and evoked in the stratum radiatum of the CA1. Both the low frequency EPSP and LTP of the EPSP were significantly increased by treatment with 4-AP. These effects were inhibited by increasing the magnesium concentration from 1 to 4 mM. Pretreatment with 20 microM DL-2-amino-5-phosphonovalerate antagonized only the increase in LTP produced by 4-AP. It is suggested that 4-AP enhances Ca influx either pre- or postsynaptically and thereby increases LTP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lee WL,Anwyl R,Rowan Mdoi
10.1016/0304-3940(86)90446-5subject
Has Abstractpub_date
1986-09-25 00:00:00pages
106-9issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90446-5journal_volume
70pub_type
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