Abstract:
:NMDA receptors play important roles in brain formation by taking part in synaptogenesis and apoptosis. In the present study, the expression of NMDA receptors was analyzed in a neural stem cell line, MSP-1, which lacks p53. p53 is a transcription factor involved in excitotoxic neuronal apoptosis. It is quite likely that p53-mediated transcription control affects the expression of NMDA receptors inducing intracellular Ca2+ signaling after neuronal differentiation and is essential for neural development. By means of calcium digital imaging, NMDA receptor-mediated Ca2+ responses were detected from cultured neurons differentiated from neural stem cells which lack p53. This result implies that p53-related apoptosis is not due to NMDA receptor expression.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yamada K,Hisatsune T,Uchino S,Nakamura T,Kudo Y,Kaminogawa Sdoi
10.1016/s0304-3940(99)00134-2keywords:
subject
Has Abstractpub_date
1999-04-02 00:00:00pages
165-7issue
1-3eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00134-2journal_volume
264pub_type
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