Abstract：
:1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(+)-induced cell death in SH-SY5Y neuroblastoma cells. We found that MPP(+)-induced apoptosis and -ROS generation were blocked by okadaic acid. MPP(+)-mediated activation of AKT was also inhibited by okadaic acid. Taken together, these results demonstrate that okadaic acid protects against MPP(+)-induced apoptosis by blocking ROS stimulation and ROS-mediated signaling pathways in SH-SY5Y cells. These data indicated that okadaic acid could provide a therapeutic strategy for the treatment of neurodegenerative diseases including Parkinson's disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ahn KH,Kim YS,Kim SY,Huh Y,Park C,Jeong JWdoi
10.1016/j.neulet.2008.10.103subject
Has Abstractpub_date
2009-01-09 00:00:00pages
93-7issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(08)01529-2journal_volume
449pub_type
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