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Effects of peptides from Phascolosoma esculenta on spatial learning and memory via anti-oxidative character in mice.

Abstract：

:This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 150mg/kg group during exploration period (P<0.05), without body weight between the weight and visual ability. 100mg/kg ferrous-chelating peptide group performed better ability of spatial learning and memory than 100mg/kg peptide group (P<0.05). qRT-PCR results showed that 50 and 100mg/kg administration peptide and 100mg/kg ferrous-chelating peptide can significantly improve mRNA expression of NR2A, NR2B and BDNF with oxidative stress status (GSH-Px, SOD, TAC and MDA), which explained mechanism for improving learning and memory ability in mice via anti-oxidative character.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Liu L,Cao J,Chen J,Zhang X,Wu Z,Xiang H

doi

10.1016/j.neulet.2016.08.012

subject

Has Abstract

pub_date

2016-09-19 00:00:00

pages

30-35

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(16)30583-3

journal_volume

631

pub_type

杂志文章

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