Abstract:
:Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment with SB, baicalin, baicalein beginning 30 min prior to noise exposure and continuing once daily throughout the study. Hearing threshold shift was assessed by auditory brain stem responses for 35 days following noise exposure. Central auditory function was evaluated by auditory middle latency responses. Cochlear function was determined based on transient evoked otoacoustic emissions. SB significantly reduced threshold shift, central auditory function damage, and cochlear function deficits, suggesting that SB may protect auditory function in NIHL and that the active constituent may be a flavonoid, baicalein.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kang TH,Hong BN,Park C,Kim SY,Park Rdoi
10.1016/j.neulet.2009.12.009subject
Has Abstractpub_date
2010-01-29 00:00:00pages
298-302issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(09)01579-1journal_volume
469pub_type
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