Abstract：
:In previous studies, chronic low-dose methylphenidate (MPH) administration during early development has been shown to increase emotional responding in adulthood. However, most studies employed male subjects, which generally show enhanced fear relative to females in laboratory tests of anxious behaviors. The present study examined the sex-dependent effects of MPH treatment on innate and learned fear behaviors. Rats were treated for 4 weeks from periadolescence through early adulthood with oral MPH. In open field testing, females showed greater levels of activity than males, and MPH (5mg/kg) decreased locomotion relative to control and 2mg/kg treatment in both sexes. In contextual fear conditioning, females exhibited less freezing than males at all retention intervals. Both sexes treated with 5mg/kg MPH showed increased fear to the shock context, although MPH treatment did not interfere with contextual discrimination in either sex. Upon reexposure to the shock context at 24h, only females treated with 5mg/kg MPH exhibited increases in freezing. MPH treatment did not disrupt extinction of contextual fear (48 h post-conditioning) in either sex. These findings illustrate subtle sex differences in the effects of prolonged MPH exposure on fear behaviors, and highlight the need to examine further the underlying mechanisms in both sexes.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bethancourt JA,Vásquez CE,Britton GBdoi
10.1016/j.neulet.2011.03.080subject
Has Abstractpub_date
2011-05-27 00:00:00pages
30-4issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(11)00394-6journal_volume
496pub_type
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：2004-04-08 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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