Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.

abstract：:We assess in mice, the electrophysiological criteria developed in humans and rats in vivo for unmyelinated (C) fibre differentiation into sub-classes, derived from the activity-induced latency increase ("slowing") in response to electrical stimulation during 6 min at 0.25 Hz followed by 3 min at 2 Hz. Fibres are consi...

journal_title：Neuroscience letters

authors： Hoffmann T,De Col R,Messlinger K,Reeh PW,Weidner C

更新日期：2015-04-10 00:00:00

abstract：:Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) ...

journal_title：Neuroscience letters

authors： Walker DG,McGeer PL

更新日期：1993-07-09 00:00:00

abstract：:The magnocellular neurones of the supraoptic nucleus (SON) and paraventricular nucleus release neuropeptide from their axon terminals and also from their dendrites. In the axon terminals, swellings known as Herring bodies are responsible for the degradation of aged, unreleased large dense-cored vesicles (LDCVs) by lys...

journal_title：Neuroscience letters

authors： Monteiro O,Wiegand UK,Ludwig M

更新日期：2011-02-01 00:00:00

abstract：:Extracellular field potentials were recorded from guinea pig accessory olfactory bulb (AOB) slices following electrical stimulation of the vomeronasal nerve layer (VNL). A single shock of the VNL provoked a characteristic damped oscillatory field potential, which consisted of a compound action potential followed by 6-...

journal_title：Neuroscience letters

authors： Sugai T,Sugitani M,Onoda N

更新日期：1995-08-25 00:00:00

abstract：:It has been shown that the incidence of cognitive impairment increases with the severity of chronic kidney disease (CKD). A previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in CKD model mice. Endoplasmic reticulum (ER) stress is thought to contribute significantly ...

journal_title：Neuroscience letters

authors： Kosuge Y,Osada N,Shimomura A,Miyagishi H,Wada T,Ishige K,Shimba S,Ito Y

更新日期：2018-06-11 00:00:00

abstract：:The purpose of the present study was to confirm the functional regulation by alpha 2-adrenoceptors of the release of serotonin (5-HT) from the rat hippocampus in vivo. Under several pharmacological conditions, extracellular levels of 5-HT were estimated by assaying its concentrations in the perfusate by high performan...

journal_title：Neuroscience letters

authors： Numazawa R,Yoshioka M,Matsumoto M,Togashi H,Kemmotsu O,Saito H

更新日期：1995-06-16 00:00:00

abstract：:In this study, we investigated the role of nitric oxide (NO) in neuronal cell death in the lipopolysaccharide (LPS)-treated rat hippocampal slice culture. Neuronal cell death was induced after a LPS treatment in a rat hippocampal slice. The region and time course of the cell death caused by LPS were different from tho...

journal_title：Neuroscience letters

authors： Lee P,Son D,Lee J,Kim YS,Kim H,Kim SY

更新日期：2003-09-25 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of neurological disability across all ages, but the elderly are particularly vulnerable and have a worse prognosis than younger individuals. To advance the understanding of long-term pathogenesis induced by TBI in the elderly, aged mice (21 -- 24 months) were given a contr...

journal_title：Neuroscience letters

authors： Onyszchuk G,LeVine SM,Brooks WM,Berman NE

更新日期：2009-03-13 00:00:00

abstract：:Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +...

journal_title：Neuroscience letters

authors： Castro-Alamancos MA,Borrell J

更新日期：1993-02-19 00:00:00

abstract：:Regeneration of reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for the activity of glutathione redox cycling during cellular peroxide detoxification. In order to test for a function of astroglial glycogen to serve as endogenous precursor for glucose-6-phosphate, the substrate for the regenera...

journal_title：Neuroscience letters

authors： Rahman B,Kussmaul L,Hamprecht B,Dringen R

更新日期：2000-09-01 00:00:00

abstract：:Non-photic stimuli, such as diurnal wheel running in rodents, phase shift the circadian clock and suppress the expression of Per1 in the suprachiasmatic nucleus (SCN). The goal of the present study was to directly decrease Per1 expression using antisense (AS) oligodeoxynucleotides to determine if such suppression prod...

journal_title：Neuroscience letters

authors： Hamada T,Antle MC,Silver R

更新日期：2004-05-20 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-csf) is a member of the hematopoietic growth factor family and demonstrates neuroprotective functions in neurodegenerative diseases. This study evaluated the radioprotective effects of G-csf in the suppression of hippocampal neurogenesis in adult mice undergoing irradiation. Th...

journal_title：Neuroscience letters

authors： Kim JS,Yang M,Jang H,Oui H,Kim SH,Shin T,Jang WS,Lee SS,Moon C

更新日期：2010-12-03 00:00:00

abstract：:N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-dependently increase...

journal_title：Neuroscience letters

authors： Martin-Fardon R,Arnaud M,Rousseau E,Kamenka JM,Privat A,Vignon J

更新日期：1996-06-28 00:00:00

abstract：:The localization of amyloid beta protein (A beta), A beta 40, A beta 42, and transthyretin (TTR) was investigated immunohistochemically in the autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Hayashi Y,Yoshida T,Sasaki N,Takamaru Y,Yamaguchi H,Tateno M,Fujii N,Takahata N

更新日期：1997-02-07 00:00:00

abstract：:Several lines of evidence suggest that the amygdala is altered functionally in humans with temporal lobe epilepsy, but little is known about neuronal interactions in the amygdala of humans or animals with chronic epilepsy. Using extracellular and intracellular recordings in horizontal slices, we tested the hypothesis ...

journal_title：Neuroscience letters

authors： Smith BN,Dudek FE

更新日期：1997-01-24 00:00:00

abstract：:Iontophoretic application of the 5-HT2 receptor agonist alpha-methyl-5-HT excited 41 neurones in the rostral ventrolateral medulla, including a population of barosensitive cells. At high ejecting currents (greater than 2-3 x threshold) the excitation was replaced by an inhibition. The excitatory responses evoked by lo...

journal_title：Neuroscience letters

authors： Wang WH,Lovick TA

更新日期：1992-07-06 00:00:00

abstract：:Focal brain lesions such as cortical dysplasia and glioneural tumors generate epileptic activity and thus may be synaptically connected with normal cortex. To test this hypothesis, we compared event-related potentials recorded directly from the medial temporal lobe (MTL) and a dysplastic lesion in eight patients with ...

journal_title：Neuroscience letters

authors： Kirschstein T,Fernández G,Grunwald T,Pezer N,Urbach H,Blümcke I,Van Roost D,Lehnertz K,Elger CE

更新日期：2003-03-06 00:00:00

abstract：:It has been reported that tyrosine administration augments clozapine-induced dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize this effect and exclude possible confounds, we conducted a series of studies in which microdialysate collection started 24 h after probe implantation, a time at whi...

journal_title：Neuroscience letters

authors： Jaskiw GE,Simpson C,Bongiovanni R,Yamamoto BK

更新日期：2004-02-26 00:00:00

abstract：:Unusual reactions to auditory stimuli are often observed in autism and may relate to ineffective inhibitory modulation of sensory input (sensory gating). A previous study of P50 sensory gating did not reveal abnormalities in high-functioning school age children [C. Kemner, B. Oranje, M.N. Verbaten, H. van Engeland, No...

journal_title：Neuroscience letters

authors： Orekhova EV,Stroganova TA,Prokofyev AO,Nygren G,Gillberg C,Elam M

更新日期：2008-03-28 00:00:00

abstract：:The present study examines the online realization of pragmatic meaning using event-related potentials (ERPs). Participants read sentences including the English quantifier some, which has both a semantic meaning (at least one) and a pragmatic meaning (not all). Unlike previous ERP studies of this phenomenon, sentences ...

journal_title：Neuroscience letters

authors： Hunt L 3rd,Politzer-Ahles S,Gibson L,Minai U,Fiorentino R

更新日期：2013-02-08 00:00:00

abstract：:UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immuno...

journal_title：Neuroscience letters

authors： Hope AD,Lashley T,Lees AJ,de Silva R

更新日期：2004-04-08 00:00:00

abstract：:The effects of Sr2+ on the transmitter release at the frog neuromuscular junction were examined electrophysiologically. The nerve trunk was stimulated by paired pulses at various time intervals after replacing extracellular Ca2+ by Sr2+, the paired-pulse facilitation at the 10 ms interval was smaller than that at 20-3...

journal_title：Neuroscience letters

authors： Tanabe N,Morota A

更新日期：1999-11-19 00:00:00

abstract：:The phenotype of neurotrophin-3 (NT-3) null mutant mice is characterized by sensory ataxia and early postnatal death. Previous analysis revealed a severe depletion of peripheral sensory, sympathetic and parasympathetic neurons. Most of the deficits are established early during embryonic development. Whereas absence of...

journal_title：Neuroscience letters

authors： Barski JJ,Helbig C,Meyer M

更新日期：2011-09-01 00:00:00

abstract：:Apolipoprotein E (ApoE) genotype was determined by polymerase chain reaction amplification and restriction digestion of DNA extracted from brain tissues of 26 patients with clinically diagnosed and pathologically verified lobar atrophy (LA) and from blood of a further 22 patients with clinical LA. Brain tissue from 50...

journal_title：Neuroscience letters

authors： Pickering-Brown SM,Siddons M,Mann DM,Owen F,Neary D,Snowden JS

更新日期：1995-03-31 00:00:00

abstract：:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measur...

journal_title：Neuroscience letters

authors： Hirsch MR,Cailla H,Wietzerbin J,Goridis C

更新日期：1986-04-11 00:00:00

abstract：:The levels of apoptosis associated proteins Bcl(2), Bax, cytochrome-c and p53 was investigated in mice cerebral cortex and cerebellum, using an experimental model of fatal murine cerebral malaria (FMCM). Owing to the activation of events central to mitochondrial dysfunctions, we monitored the structural integrity of m...

journal_title：Neuroscience letters

authors： Kumar KA,Babu PP

更新日期：2002-09-06 00:00:00

abstract：:Face processing is unique to human beings and is likely to have special neuronal properties. We studied one of these properties, categorical representation of the face in perception processing (perception) and in memory recall processing (imagery), using the face and building stimuli. The same building-selective areas...

journal_title：Neuroscience letters

authors： Sung YW,Ogawa S

更新日期：2008-12-19 00:00:00

abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

journal_title：Neuroscience letters

authors： Zampini M,Mawhinney S,Spence C

更新日期：2006-06-12 00:00:00

abstract：:Monosynaptic evoked responses were used to localize dorsal root ganglion (DRG) afferent terminals within organotypic fetal mouse spinal cord explants which had been chronically exposed to purified bovine gangliosides during early development. Ganglioside grown cultures showed a highly significant increase in dorsal co...

journal_title：Neuroscience letters

authors： Baker RE

更新日期：1983-10-31 00:00:00

abstract：:Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength...

journal_title：Neuroscience letters

authors： Xu X,Jerskey BA,Cote DM,Walsh EG,Hassenstab JJ,Ladino ME,Clark US,Labbe DR,Gunstad JJ,Poppas A,Cohen RA,Hoge RD,Sweet LH

更新日期：2014-02-07 00:00:00