Abstract：
:N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-dependently increased DA levels with a maximum effect 60 min post injection. BTCP (20 mg/kg) had a greater peak effect than cocaine (40 mg/kg). For doses inducing similar behavioral effects (cocaine, 20mg/kg; BTCP, 10 mg/kg) similar DA increases were observed in the striatum and the nucleus accumbens. Although both drugs bind on the DA transporter on different sites and induce different behavioral effects when administered chronically, their acute administration increased striatal DA level in a similar way.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Martin-Fardon R,Arnaud M,Rousseau E,Kamenka JM,Privat A,Vignon Jdoi
10.1016/0304-3940(96)12744-0subject
Has Abstractpub_date
1996-06-28 00:00:00pages
179-82issue
3eissn
0304-3940issn
1872-7972pii
0304394096127440journal_volume
211pub_type
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