Abstract:
:Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +/- 0.2 Hz. The motor activity induced by GABAA receptor blockade was suppressed by application through the dialysis probe of a non-NMDA (N-methyl-D-aspartate) receptor antagonist, but not by an NMDA receptor antagonist. Glutamate eliminated the blocking effect of the non-NMDA receptor antagonist upon GABAA receptor blockade mediated activity. In conclusion, the results show that an excitatory input to the motor cortical output is mediated through a non-NMDA receptor, therefore the effects of cortical disinhibition may be controlled by non-NMDA receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Castro-Alamancos MA,Borrell Jdoi
10.1016/0304-3940(93)90531-osubject
Has Abstractpub_date
1993-02-19 00:00:00pages
183-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90531-Ojournal_volume
150pub_type
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