Expression of synaptotagmin I or II promotes neurite outgrowth in PC12 cells.

abstract：:Extracellular dopamine and noradrenaline concentrations in the medial prefrontal cortex were determined using online microdialysis in freely moving rats during classical appetitive or aversive conditioning to a contextual conditioned stimulus (CS). As CS we used placement in a Skinner box where either foot shocks or f...

journal_title：Neuroscience letters

authors： Feenstra MG,Teske G,Botterblom MH,De Bruin JP

更新日期：1999-09-17 00:00:00

abstract：:In experiments using a synaptosomal preparation from the striatum and nucleus accumbens, somatostatin caused a dose-dependent increase in dopamine synthesis. This increase was additive with that produced by 8-BrcAMP but not with that produced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and was bl...

journal_title：Neuroscience letters

authors： Chowdhury M,Steardo L,Fillenz M

更新日期：1987-11-23 00:00:00

abstract：:The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neu...

journal_title：Neuroscience letters

authors： Mori H,Arai T,Ishii H,Adachi T,Endo N,Makino K,Mori K

更新日期：1998-01-30 00:00:00

abstract：:A traditional analysis of intra-encephalic auditory evoked potentials does not highlight the dynamical evolution of the auditory 'information' processing in neither time nor space. This work presents a method for tracing such signal evolution throughout the primary auditory pathway in the mesencephalon of adult anesth...

journal_title：Neuroscience letters

authors： Moraes MF,Del Vecchio F,Terra VC,Garcia-Cairasco N

更新日期：2000-04-21 00:00:00

abstract：:Substance P caused a depolarization of cultured spinal neurones which was often accompanied by a decrease in membrane conductance. The peptide usually had no effect on the membrane potential and resistance of glial cells. In contrast to the depolarization by glutamate, which is associated with an influx of Na+ and an ...

journal_title：Neuroscience letters

authors： Hösli L,Hösli E,Zehntner C,Landolt H

更新日期：1981-07-02 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling o...

journal_title：Neuroscience letters

authors： Nakajima S,Numakawa T,Adachi N,Yoon HS,Odaka H,Ooshima Y,Kunugi H

更新日期：2016-03-11 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:The present work describes the formation of a transient efferent axonal projection from the isthmo-optic nucleus (ION) to the ipsilateral optic tectum of the chick embryo. Local application of either the carbocyanine dye DiI or rhodamine-B-isothiocyanate (RITC) to the superficial layers of the optic tectum resulted in...

journal_title：Neuroscience letters

authors： Wizenmann A,Thanos S

更新日期：1990-06-08 00:00:00

abstract：:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos in...

journal_title：Neuroscience letters

authors： Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

更新日期：1994-01-03 00:00:00

abstract：:Our previous genetic and proteomic studies demonstrated that dynamin 1 is significantly associated with nicotine dependence (ND) in human smokers and its expression is highly modulated by nicotine in the brains of animals. To provide further molecular evidence for the involvement of dynamin 1 in the etiology of ND, we...

journal_title：Neuroscience letters

authors： Xu Q,Li MD

更新日期：2011-02-11 00:00:00

abstract：:Several studies have indicated that higher levels of childhood aerobic fitness is associated with superior cognitive function, and this association is disproportionately observed in tasks requiring greater top-down control. We designed the current study to clarify the relationship between childhood fitness and top-dow...

journal_title：Neuroscience letters

authors： Kamijo K,Takeda Y,Takai Y,Haramura M

更新日期：2016-10-06 00:00:00

abstract：:The efficacy of beta 1-adrenoceptor-G protein coupling was studied in postmortem temporal cortex synaptic membranes from a series of control and Alzheimer's disease subjects. For the control cases, the non-hydrolysable GTP analogue 5'-guanylylimidodiphosphate (Gpp[NH]p) gave a significant reduction in the affinity of ...

journal_title：Neuroscience letters

authors： Cowburn RF,Vestling M,Fowler CJ,Ravid R,Winblad B,O'Neill C

更新日期：1993-06-11 00:00:00

abstract：:C57 black mice given a single injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 40 mg/kg, developed marked reduction of striatal dopamine content and loss of dopaminergic neurons in the zona compacta of the substantia nigra. However, pretreatment with any one of four different antioxidants, alpha-tocop...

journal_title：Neuroscience letters

authors： Perry TL,Yong VW,Clavier RM,Jones K,Wright JM,Foulks JG,Wall RA

更新日期：1985-09-30 00:00:00

abstract：:We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared...

journal_title：Neuroscience letters

authors： Laudiero LB,Aloe L,Levi-Montalcini R,Buttinelli C,Schilter D,Gillessen S,Otten U

更新日期：1992-11-23 00:00:00

abstract：:The role of the dorsal hippocampus in the different stages of blocking was examined in a taste aversion learning task. Blocking is a learning effect in which one previously conditioned element of a compound makes the conditioning of the added element difficult. An effective blocking procedure with one trial in each st...

journal_title：Neuroscience letters

authors： Gallo M,Cándido A

更新日期：1995-02-15 00:00:00

abstract：:The alpha1-adrenergic receptors may contribute to cognitive functions relevant to schizophrenia. Following the discovery of an association between polymorphisms in the regulatory region of the alpha1A-adrenergic receptor and schizophrenia we investigated the expression of mRNA for this receptor between schizophrenics ...

journal_title：Neuroscience letters

authors： Clark DA,Mancama D,Kerwin RW,Arranz MJ

更新日期：2006-07-03 00:00:00

abstract：:Caffeine is a widely consumed substance that elicits psychomotor stimulant effects and also displays addictive properties. In order to assess the effect of caffeine on striatal neuropeptide mRNA expression, male rats were injected (i.p.) with caffeine at 20, 40 or 80 mg/kg of body weight twice daily for 9 consecutive ...

journal_title：Neuroscience letters

authors： Datta U,Noailles PA,Kraft M,Zhang Y,Angulo JA

更新日期：1997-08-01 00:00:00

abstract：:The phenotype of neurotrophin-3 (NT-3) null mutant mice is characterized by sensory ataxia and early postnatal death. Previous analysis revealed a severe depletion of peripheral sensory, sympathetic and parasympathetic neurons. Most of the deficits are established early during embryonic development. Whereas absence of...

journal_title：Neuroscience letters

authors： Barski JJ,Helbig C,Meyer M

更新日期：2011-09-01 00:00:00

abstract：:The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...

journal_title：Neuroscience letters

authors： Paine S,Bedford L,Thorpe JR,Mayer RJ,Cavey JR,Bajaj N,Sheppard PW,Lowe J,Layfield R

更新日期：2009-09-04 00:00:00

abstract：:To identify the roles of gamma-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure ...

journal_title：Neuroscience letters

authors： Kang TC,Kim HS,Seo MO,Park SK,Kwon HY,Kang JH,Won MH

更新日期：2001-09-07 00:00:00

abstract：:Postmitotic neurons were generated from the human NT2 teratocarcinoma cell line in a novel cell aggregate differentiation procedure. The NT2 model neurons express punctate immunoreactivity for synapsin and for cell markers related to GABAergic and glutamatergic neurotransmission. Using the outside-out patch-clamp conf...

journal_title：Neuroscience letters

authors： Podrygajlo G,Song Y,Schlesinger F,Krampfl K,Bicker G

更新日期：2010-01-14 00:00:00

abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...

journal_title：Neuroscience letters

authors： Saxon DW

更新日期：2003-03-13 00:00:00

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:The content of two neuropeptides, somatostatin (SRIF) and neuropeptide Y (NPY) has been determined in two cerebral cortical areas of Alzheimer's disease brain and in age-matched control brains. The content of SRIF-like immunoreactivity (SRIF-LI) was found to be decreased in Alzheimer temporal cortex (Brodmann area 21)...

journal_title：Neuroscience letters

authors： Dawbarn D,Rossor MN,Mountjoy CQ,Roth M,Emson PC

更新日期：1986-09-25 00:00:00

abstract：:In order to study the influence of curare and atropine on the gamma-aminobutyric acid (GABA)-evoked chloride current, we have investigated cultures of hippocampal and septal region neurons from embryonic rats (E18). The neurons were cultured under the trophic influence of spatially separated astrocytes in serum-free m...

journal_title：Neuroscience letters

authors： Siebler M,Köller H,Schmalenbach C,Müller HW

更新日期：1988-11-11 00:00:00

abstract：:N-Acetylaspartylglutamate (NAAG) is a dipeptide, and has been demonstrated to be a putative neurotransmitter in the brain. We hereby report the toxicity of NAAG in sagittal slices of mouse brain, in vitro, which is prevented by both N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists. Incubation of mouse bra...

journal_title：Neuroscience letters

authors： Pai KS,Ravindranath V

更新日期：1991-05-13 00:00:00

abstract：:The cyclic AMP/protein kinase A signaling pathway is thought to be involved in neural differentiation of mesenchymal stem cells. In the present study, we examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cel...

journal_title：Neuroscience letters

authors： Ishizuka T,Goshima H,Ozawa A,Watanabe Y

更新日期：2012-09-06 00:00:00

abstract：:A FORTRAN computer program is described which enables solution of a set of partial differential equations describing synaptic transmission, including neurotransmitter diffusion, binding to receptors on the postsynaptic membrane with subsequent formation of open ion-conducting channels, and hydrolysis. Integration is p...

journal_title：Neuroscience letters

authors： Madsen BW,Edeson RO,Lam HS,Milne RK

更新日期：1984-07-13 00:00:00

abstract：:In rats anesthetized with pentobarbital or a mixture of urethane and chloralose, horseradish peroxidase (HRP) was injected into the intermediolateral column of the spinal cord (Th7 and Th9) or the posterior pituitary lobe. HRP positive cells were found mainly in the dorsomedial part of the paraventricular nuclease (PV...

journal_title：Neuroscience letters

authors： Ono T,Nishino H,Sasaka K,Muramoto K,Yano I,Simpson A

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND/AIM:Depressive disorders are multifactorial diseases, in which cognitive impairment is one of the characteristic feature. One of the molecules that regulate of various cognitive, emotional and behavioural processes is nitric oxide (NO), synthesized from l-arginine by a family of isoformic enzymes known as ni...

journal_title：Neuroscience letters

authors： Talarowska M,Gałecki P,Maes M,Orzechowska A,Chamielec M,Bartosz G,Kowalczyk E

更新日期：2012-02-29 00:00:00