Abstract:
:Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of other UCP paralogs remain less clear. Here, we critically discuss the existence of brain UCPs and their potential roles. Applying phylogenetic classification of novel UCPs, we summarize the evidence for brain UCP1 among vertebrates, the role of UCP2 in specific brain areas, and the existence of brain-specific UCPs. The phylogenetic analyses and discussion on functional data should alert the scientific community that the molecular function of so-called UCP1 homologues is by far not clarified and possibly relates to neither thermogenesis nor mitochondrial uncoupling.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gaudry MJ,Jastroch Mdoi
10.1016/j.neulet.2018.12.027subject
Has Abstractpub_date
2019-03-23 00:00:00pages
140-145eissn
0304-3940issn
1872-7972pii
S0304-3940(18)30872-3journal_volume
696pub_type
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