Molecular evolution of uncoupling proteins and implications for brain function.

Abstract:

:Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of other UCP paralogs remain less clear. Here, we critically discuss the existence of brain UCPs and their potential roles. Applying phylogenetic classification of novel UCPs, we summarize the evidence for brain UCP1 among vertebrates, the role of UCP2 in specific brain areas, and the existence of brain-specific UCPs. The phylogenetic analyses and discussion on functional data should alert the scientific community that the molecular function of so-called UCP1 homologues is by far not clarified and possibly relates to neither thermogenesis nor mitochondrial uncoupling.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Gaudry MJ,Jastroch M

doi

10.1016/j.neulet.2018.12.027

subject

Has Abstract

pub_date

2019-03-23 00:00:00

pages

140-145

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(18)30872-3

journal_volume

696

pub_type

杂志文章,评审
  • Somatosensory amplification and its relationship to somatosensory, auditory, and visual evoked and event-related potentials (P300).

    abstract::Somatosensory amplification refers to the tendency to experience benign and ambiguous somatic sensation as intense, noxious, and disturbing. The construct is helpful in assessing the perceptual style of a variety of somatizing conditions, but there is no human study clarifying the effects of neurological function on s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.01.021

    authors: Nakao M,Barsky AJ,Nishikitani M,Yano E,Murata K

    更新日期:2007-03-26 00:00:00

  • Functional ectopic neural lobe increases GAP-43 expression via PI3K/AKT pathways to alleviate central diabetes insipidus after pituitary stalk lesion in rats.

    abstract::Central diabetes insipidus can occur after hypothalamic-hypophyseal tract injury. This injury is linked with a deficit in circulating vasopressin and oxytocin, which are produced in the supraoptic nuclei and the hypothalamic paraventricular nuclei. Previous studies indicate that an ectopic neural lobe forms after pitu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.02.038

    authors: Feng Z,Ou Y,Zhou M,Wu G,Ma L,Zhang Y,Liu Y,Qi S

    更新日期:2018-04-23 00:00:00

  • Influence of task difficulty on the features of event-related potential during visual oddball task.

    abstract::We present a comprehensive analysis of the change in event-related potential (ERP) due to task difficulty during a visual oddball task. Specifically, we investigated the inter-subject difference in difficulty-related change of ERP patterns using single-trial ERP analysis focusing on P300 and P2 components. ERPs were r...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.09.004

    authors: Kim KH,Kim JH,Yoon J,Jung KY

    更新日期:2008-11-14 00:00:00

  • P50 suppression deficits and psychopathology in Han Chinese patients with schizophrenia.

    abstract:OBJECTIVE:Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patt...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.06.009

    authors: Zhu XL,Tan SP,Wang ZR,Zhang JG,Li D,Fan FM,Zhao YL,Zou YZ,Tan YL,Yang F,Zhang XY

    更新日期:2017-07-13 00:00:00

  • Does barbiturate anesthesia modify the neuronal properties of the somatosensory thalamus? A single-unit study related to nociception in the awake-pentobarbital-treated rat.

    abstract::By means of extracellular recordings, we studied thalamic ventrobasal complex neurons of rats tested first awake, and then anesthetized with pentobarbital. In both conditions, we found two groups of units in both states. The first group, displaying a spontaneous bursting activity, was not obviously responding to perip...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11847-p

    authors: Montagne-Clavel J,Olivéras JL

    更新日期:1995-08-18 00:00:00

  • Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus.

    abstract::Bilateral complete transection of the fimbria-fornix causes a significant increase in nerve growth factor (NGF) content both in the septum and hippocampus of the adult rat as measured by a sensitive immunoassay 7 days after lesioning. The finding, that elevation of NGF in septum (250%) was much more pronounced than th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90449-0

    authors: Weskamp G,Gasser UE,Dravid AR,Otten U

    更新日期:1986-09-25 00:00:00

  • Antinociception from the administration of beta-endorphin into the periaqueductal gray of rat is enhanced while that of morphine is inhibited by barbiturate anesthesia.

    abstract::Pentobarbital anesthesia causes about a 10-fold increase in the antinociceptive potency of beta-endorphin microinjected into the periaqueductal gray (PAG) region of the rat brain. The antinociceptive response to PAG morphine was markedly attenuated during anesthesia, but returned as the rats regained consciousness. As...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90063-d

    authors: Smith DJ,Robertson B,Monroe PJ

    更新日期:1992-11-09 00:00:00

  • Alterations in acetylcholine-induced stimulation of inositol phospholipid hydrolysis in the dorsal hippocampus of kindled rats.

    abstract::Agonist-induced turnover or release of inositolphosphates (IP) was studied in the dorsal and the ventral hippocampus 24 h, 1 month, and 3 months after the last electrical stimulus of kindled rats. A significant increase in acetylcholine (ACh)-stimulated IP turnover was observed in dorsal, but not ventral, hippocampus ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90248-8

    authors: Zhang WQ,Tandon P,Sobotka TJ,Hong JS,Tilson HA

    更新日期:1990-10-02 00:00:00

  • Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients.

    abstract::Alternative cleavage of the amyloid precursor protein (APP) results in generation and secretion of both soluble APP (sAPP) and beta-amyloid (Abeta). Abeta is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients. Using Western blotting, we compared the levels of alpha-secreta...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00929-5

    authors: Sennvik K,Fastbom J,Blomberg M,Wahlund LO,Winblad B,Benedikz E

    更新日期:2000-01-14 00:00:00

  • Prevention by maternal pancreatic islet transplantation of hypothalamic malformation in offspring of diabetic mother rats is already detectable at weaning.

    abstract::Exposure to gestational diabetes (GD) in rats leads to dysplasia of the ventromedial hypothalamic nucleus (VMN), decisively involved into the regulation of body weight and metabolism. Recently, we have shown here that VMN malformation is absent in adult offspring of GD mothers treated by pancreatic islet transplantati...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.08.066

    authors: Harder T,Franke K,Fahrenkrog S,Aerts L,Van Bree R,Van Assche FA,Plagemann A

    更新日期:2003-12-11 00:00:00

  • High and low nightly running behavior associates with nucleus accumbens N-Methyl-d-aspartate receptor (NMDAR) NR1 subunit expression and NMDAR functional differences.

    abstract::The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.02.011

    authors: Grigsby KB,Kovarik CM,Rottinghaus GE,Booth FW

    更新日期:2018-04-03 00:00:00

  • 2-Amino-5-phosphonovalerate attenuates the severe hypoglycemia-induced loss of perforant path-evoked field potentials in the rat hippocampus.

    abstract::The effects of severe hypoglycemia on perforant path-evoked field potentials were examined in the rat hippocampus. Although a complete loss of this response was noted when blood glucose concentration fell below 1 mM, this occurred before cessation of electroencephalogram (EEG) activity. Both spontaneous and evoked res...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90418-6

    authors: Butcher SP,Jacobson I,Sandberg M,Hagberg H,Hamberger A

    更新日期:1987-05-19 00:00:00

  • Coxsackievirus B4-induced neuronal apoptosis in rat cortical cultures.

    abstract::Enterovirus infections of the central nervous system (CNS) are common and important causes of morbidity in immunocompromised children and adults. In this study we identify and characterize coxsackievirus B4-induced neuronal death. To investigate the CNS pathophysiology resulting from this viral infection, cultured rat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00340-3

    authors: Joo CH,Kim YK,Lee H,Hong H,Yoon SY,Kim D

    更新日期:2002-07-05 00:00:00

  • The effects of morphine administered into the vertebral artery on the somatosympathetic A- and C-reflexes in anesthetized cats.

    abstract::The effects of morphine (0.2-200 micrograms/kg) administered into the brain stem via a vertebral artery on the somatosympathetic A- and C-reflexes evoked in a cardiac sympathetic nerve by electrical stimulation of somatic myelinated (A) and unmyelinated (C) afferent nerve fibers in anesthetized cats were examined. The...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90916-u

    authors: Kato J,Meguro K,Sato A,Sato Y

    更新日期:1992-04-27 00:00:00

  • Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.

    abstract::Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01723-7

    authors: Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

    更新日期:2001-01-26 00:00:00

  • Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid.

    abstract::Stereotaxic injections of ibotenic acid (IBO) and kainic acid (KA) into either the dorsal hippocampus or the lateral cerebroventricle were performed in order to determine the relative potencies of the drugs and the vulnerability of different hippocampal cell types to their neurotoxic action, IBO was found to be approx...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)96117-2

    authors: Köhler C,Schwarcz R,Fuxe K

    更新日期:1979-12-01 00:00:00

  • Spontaneous openings of large and small conductance acetylcholine receptor channels in Xenopus myocytes.

    abstract::Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90092-8

    authors: Rojas L,Zuazaga C

    更新日期:1991-04-01 00:00:00

  • Effects of human, rat and porcine galanins on cardiac vagal action and blood pressure in the anaesthetised cat.

    abstract::Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90659-u

    authors: Ulman LG,Evans HF,Iismaa TP,Potter EK,McCloskey DI,Shine J

    更新日期:1992-02-17 00:00:00

  • Vasopressin and oxytocin regulation of cyclic AMP accumulation in rat hypothalamo-neurohypophysial explants in vitro.

    abstract::Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskoli...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90076-l

    authors: Meeker RB,Michels KM,Hayward JN

    更新日期:1990-07-03 00:00:00

  • Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine.

    abstract::We recently showed that dopamine (DA) and serotonin (5-HT) exert anticonvulsant effects against limbic seizures in rats mediated by hippocampal D(2) and 5-HT(1A) receptor stimulation. For exogenously administered monoamines, anticonvulsant activity was only observed following 70--400% and 80--350% increases in baselin...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.07.049

    authors: Clinckers R,Smolders I,Meurs A,Ebinger G,Michotte Y

    更新日期:2005-12-16 00:00:00

  • The recognition potential reflects an intermediate level of visual representation.

    abstract::A well-known event-related potential (ERP) component-the recognition potential (RP) is a response to recognizable stimuli, peaking at around 200-250 ms. The aim of the present study is to put to the test the contrasting perceptual and semantic accounts of the RP, with manipulation of word meaning and presentation form...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.02.047

    authors: Zhang Y,Liu Q,Zhang Q

    更新日期:2009-04-17 00:00:00

  • Segregated distribution of nitric oxide synthase-positive cells in the periglomerular region of typical and atypical olfactory glomeruli.

    abstract::Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. Dorsomedial and ventrolateral atypical glomeruli contained similar number of ND/NOS-positive periglomeru...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12424-1

    authors: Crespo C,Porteros A,Arévalo R,Briñón JG,Aijón J,Alonso JR

    更新日期:1996-03-01 00:00:00

  • Distribution of choline acetyltransferase immunoreactivity in the alimentary tract of the barnacle Balanus amphitrite (Cirripedia, Crustacea).

    abstract::To date only peptidergic innervation has been described in the alimentary tract of barnacles. In the present work the presence and distribution of choline acetyltransferase (ChAT), the acetylcholine (ACh) synthesizing enzyme, was investigated by immunohistochemistry in the alimentary tract of the adult barnacle Balanu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.09.050

    authors: Gallus L,Ferrando S,Bottaro M,Girosi L,Ramoino P,Diaspro A,Aluigi MG,Tagliafierro G

    更新日期:2006-12-06 00:00:00

  • Effects on reflex bladder activity of chemical stimulation of small diameter afferents from skeletal muscle in the cat.

    abstract::In anesthetized cats selective activation of fine muscle afferents of the hindlimb by KCl or bradykinin (Brad.) induced reflex changes in the urinary bladder. The nature of the reflex responses depended on the functional state of the bladder: they were excitatory when the bladder was quiescent and inhibitory during la...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)90048-x

    authors: Sato A,Sato Y,Schmidt PF

    更新日期:1979-01-01 00:00:00

  • Presynaptic large-conductance calcium-activated potassium channels control synaptic transmission in the superficial dorsal horn of the mouse.

    abstract::Large-conductance calcium-activated potassium channels (BK channels) have been suggested to play a substantial role in synaptic transmission in the spinal cord dorsal horn. In the present experiments, we attempted to clarify the physiological significance of BK channels in the modulation of synaptic transmission in th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.08.022

    authors: Furukawa N,Takasusuki T,Fukushima T,Hori Y

    更新日期:2008-10-17 00:00:00

  • Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells.

    abstract::Recent studies have shown that the inhibition of histone deacetylases (HDACs) induces the differentiation of diverse cancer and stem cells, which suggests HDAC inhibitors may be good candidates for the induction of stem cell differentiation. In this study, we investigated the effects of a HDAC inhibitor, valproic acid...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.08.059

    authors: Jeong SG,Ohn T,Kim SH,Cho GW

    更新日期:2013-10-25 00:00:00

  • Inflammation induced increase of fluoride resistant acid phosphatase (FRAP) activity in the spinal dorsal horn in rats.

    abstract::Fluoride-resistant acid phosphatase (FRAP) has been suggested as an enzymatic marker for nociceptive primary afferent terminals in the spinal dorsal horn, however there has not been demonstrated a direct functional relation between FRAP activity and an increased nociceptive transmission. For this purpose, we quantitat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)01323-x

    authors: Glykys J,Guadama M,Marcano L,Ochoa E,Eblen-Zajjur A

    更新日期:2003-02-13 00:00:00

  • Neurofunctional correlates of esthetic and moral judgments.

    abstract::Recent neuroimaging studies indicate that there may be common ground for esthetic and moral judgments. However, because previous studies focused on either esthetic or moral judgments and did not compare the two directly, the issue remains open whether a common ground actually exists. We employed functional magnetic re...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.11.053

    authors: Avram M,Gutyrchik E,Bao Y,Pöppel E,Reiser M,Blautzik J

    更新日期:2013-02-08 00:00:00

  • Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex.

    abstract::Intracellular and extracellular recordings were obtained from layers II-III of slices of adult rat neocortex maintained in vitro. Excitatory postsynaptic potentials (EPSPs) and epileptiform discharges (paroxysmal depolarizing shifts, PDSs) were evoked in the presence of bicuculline methiodide. Responses were monitored...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90111-2

    authors: Burke JP,Hablitz JJ

    更新日期:1994-06-06 00:00:00

  • Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum.

    abstract::Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrob...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)00925-3

    authors: Ueda H,Baba T,Terada N,Kato Y,Fujii Y,Takayama I,Mei X,Ohno S

    更新日期:2000-04-07 00:00:00