Abstract:
:Fibroblast growth factor (FGF), epidermal growth factor (EGF) and insulin added in combination to the culture medium in which normal human muscle was cultured caused a 4.0-fold (P less than 0.005) increase of the total number of nicotinic acetylcholine receptors (AChRs) and a 4.5-fold (P less than 0.001) increase in AChR aggregation. Individually, only FGF caused a 3.0-fold increase (P less than 0.005) in AChR aggregation, without influencing the total number of AChRs. To the contrary, insulin alone caused a 2.0-fold increase (P less than 0.05) in the total number of AChRs without influencing AChR aggregation. These findings show that these three polypeptide growth factors exert a neuronal-like influence on cultured human muscle in regard to AChRs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Askanas V,Cave S,Gallez-Hawkins G,Engel WKdoi
10.1016/0304-3940(85)90427-6subject
Has Abstractpub_date
1985-10-24 00:00:00pages
213-9issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(85)90427-6journal_volume
61pub_type
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