Abstract:
:Brain derived neurotrophic factor (BDNF), known to promote survival of neurons, has recently been involved in the regulation of endothelial cells and was shown to possess immunoregulatory properties. We therefore asked whether BDNF has immunoregulating effects in human cerebral endothelial cells (HCEC). Adult HCEC expressed vascular cell adhesion molecule-1 and HLA class II following stimulation with tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, respectively, but not after BDNF treatment. Addition of BDNF did not modulate the effects of TNF-alpha and IFN-gamma on HCEC, including TNF-alpha induced interleukin-8. Fluorescent activated cell sorting, RT-PCR, and immunohistochemistry indicated that HCEC do not express the trkB or p75 receptors involved in BDNF signaling. These results demonstrate that adult HCEC are not a likely target for BDNF. Novel factors regulating HCEC remain to be identified.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ruprecht K,Stadelmann C,Hummel V,Klein O,Brück W,Rieckmann Pdoi
10.1016/s0304-3940(02)00778-4keywords:
subject
Has Abstractpub_date
2002-09-20 00:00:00pages
175-8issue
2eissn
0304-3940issn
1872-7972pii
S0304394002007784journal_volume
330pub_type
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