Neuronal localisation of benzodiazepine receptors in cerebellum.

Abstract:

:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the cerebllum of mutant nervous mouse (nr/nr) where Purkinje cells are degenerated but in the mutant weaver mouse where granule cells are degenerated. These results show that benzodiazepine receptors are located mainly on neurons; both on Purkinje cells and other neurons, but not to a great extent on granule cells.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Braestrup C,Nielsen M,Biggio G,Squires RF

doi

10.1016/0304-3940(79)91497-6

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

219-24

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(79)91497-6

journal_volume

13

pub_type

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