A phylogenetically conserved hnRNP type A/B protein from squid brain.

Abstract:

:Eukaryotic mRNA precursors are co-transcriptionally assembled into ribonucleoprotein complexes. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in mRNA translocation, stability, subcellular localization and regulation of mRNA translation. About 20 major classes of hnRNPs have been identified in mammals. In a previous work, we characterized a novel, strongly-basic, RNA-binding protein (p65) in presynaptic terminals of squid neurons presenting homology with human hnRNPA/B type proteins, likely involved in local mRNA processing. We have identified and sequenced two hnRNPA/B-like proteins associated with tissue purified squid p65: Protein 1 (36.3 kDa, IP 7.1) and Protein 2 (37.6 kDa, IP 8.9). In the present work we generated an in silico, tridimensional, structural model of squid hnRNPA/B-like Protein 2, which showed highly conserved secondary and tertiary structure of RNA recognition motifs with human hnRNPA1 protein, as well as illustrated the potential for squid Protein 2 stable homodimerization. This was supported by biophysical measurements of bacterially expressed, recombinant protein. In addition, we induced expression of squid hnRNPA/B-like Protein 2 in human neuroblastoma cells (SH-SY5Y) and observed an exclusively nuclear localization, which depended on an intact C-terminal amino acid sequence and which relocated to cytoplasm particles containing PABP when the cells were challenged with sorbitol, suggesting an involvement with stress granule function.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lopes GS,Lico DTP,Silva-Rocha R,de Oliveira RR,Sebollela A,Paçó-Larson ML,Larson RE

doi

10.1016/j.neulet.2019.01.002

subject

Has Abstract

pub_date

2019-03-23 00:00:00

pages

219-224

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(19)30002-3

journal_volume

696

pub_type

杂志文章
  • Antipyretic effects of acupuncture on the lipopolysaccharide-induced fever and expression of interleukin-6 and interleukin-1 beta mRNAs in the hypothalamus of rats.

    abstract::We observed the changes of body temperature and the cytokine expressions in the hypothalamus of rats to investigate the effect and mechanism of antipyretic action of acupuncture. Lipopolysaccharide (LPS, i.p., 2.5 mg/kg) was injected into rats and manual acupuncture was performed on Shaofu (HT8), Zutonggu (BL66) or Xi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02538-1

    authors: Son YS,Park HJ,Kwon OB,Jung SC,Shin HC,Lim S

    更新日期:2002-02-08 00:00:00

  • Testosterone regulates androgen and estrogen receptor immunoreactivity in rat substantia nigra pars reticulata.

    abstract::At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes....

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)01317-4

    authors: Ravizza T,Velísková J,Moshé SL

    更新日期:2003-02-20 00:00:00

  • Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

    abstract::Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.022

    authors: Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

    更新日期:2005-12-30 00:00:00

  • Anterograde neuronal tracing of retinohypothalamic projections in the hamster--possible innervation of substance P-containing neurons in the suprachiasmatic nucleus.

    abstract::The retinohypothalamic tract (RHT) in the Djungarian hamster Phodopus sungorus was studied using anterograde neuronal transport of cholera toxin subunit B (CTB) following unilateral intraocular injection. A major projection terminates bilaterally in the hypothalamic suprachiasmatic nuclei (SCN). In the anterior ventra...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90116-3

    authors: Reuss S,Decker K,Hödl P,Sraka S

    更新日期:1994-06-06 00:00:00

  • Ruthenium red prevents capsaicin-induced neurotoxic action on sensory fibers of the guinea pig ileum.

    abstract::Capsaicin, a neurotoxin which impairs some primary afferent nerve fibers, was locally applied to the mesenteric nerve trunks of adult guinea pigs. The effect of capsaicin was studied on contractile responses of the ileum to mesenteric nerve stimulation (20 Hz). Exposure of the mesenteric nerve to capsaicin (1 microM) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90218-8

    authors: Jin JG,Takaki M,Nakayama S

    更新日期:1989-11-20 00:00:00

  • Dopamine and noradrenaline release in the prefrontal cortex of rats during classical aversive and appetitive conditioning to a contextual stimulus: interference by novelty effects.

    abstract::Extracellular dopamine and noradrenaline concentrations in the medial prefrontal cortex were determined using online microdialysis in freely moving rats during classical appetitive or aversive conditioning to a contextual conditioned stimulus (CS). As CS we used placement in a Skinner box where either foot shocks or f...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00601-1

    authors: Feenstra MG,Teske G,Botterblom MH,De Bruin JP

    更新日期:1999-09-17 00:00:00

  • Saccular stimulation of the human cortex: a functional magnetic resonance imaging study.

    abstract::Recent imaging studies have reported the projection of semicircular canal signals onto wide regions of the cerebral cortex but little is known about otolith projections onto the cerebral cortex. We used functional magnetic resonance imaging (fMRI) to investigate the activation of the cortex by loud clicks that selecti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.06.036

    authors: Miyamoto T,Fukushima K,Takada T,de Waele C,Vidal PP

    更新日期:2007-08-09 00:00:00

  • No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.

    abstract::Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large se...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00035-x

    authors: Wavrant-DeVrièze F,Rudrasingham V,Lambert JC,Chakraverty S,Kehoe P,Crook R,Amouyel P,Wu W,Holmans P,Rice F,Pérez-Tur J,Frigard B,Morris JC,Carty S,Cottel D,Tunstall N,Lovestone S,Petersen RC,Chartier-Harlin MC,Goate

    更新日期:1999-03-05 00:00:00

  • Voltage- and use-dependent inhibition by amphetamine of field potentials and Na+ current in rat nucleus accumbens neurons.

    abstract::The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and who...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00556-4

    authors: Huang RC,Lin JY

    更新日期:1998-08-07 00:00:00

  • D-cycloserine enhances both intrinsic excitability of CA1 hippocampal neurons and expression of activity-regulated cytoskeletal (Arc) protein.

    abstract::The interaction of NMDA receptor (NMDAR) activation and other mechanisms regulating neuronal excitability have not been thoroughly described. While excess activation of NMDARs results in excitotoxicity, partial activation of NMDARs by d-cycloserine (DCS) is nootropic, enhancing both acquisition and extinction of memor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.04.035

    authors: Donzis EJ,Thompson LT

    更新日期:2014-06-13 00:00:00

  • Stimulatory effects of the central amygdaloid nucleus on pancreatic exocrine secretion in rats.

    abstract::The effects of electrical stimulation of the central (CE) and basolateral (BL) amygdaloid nuclei on pancreatic exocrine secretion were tested in urethane-anesthetized rats. Electrical stimulation (0.1 mA, 1 ms, 40 Hz) of the CE significantly increased basal and hormone (secretin+cholecystokinin-8)-infused pancreatic e...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90352-2

    authors: Hahn SJ,Yoon SH,Sim SS,Rhie DJ,Jo YH,Kim MS

    更新日期:1994-03-14 00:00:00

  • Stria terminalis conveys a facilitatory estrogen effect on female rat lordosis reflex.

    abstract::The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week interval...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)11173-g

    authors: Takeo T,Kudo M,Sakuma Y

    更新日期:1995-01-23 00:00:00

  • Increase in postsynaptic density material in optic target neurons of the rat suprachiasmatic nucleus after bilateral enucleation.

    abstract::During and after degeneration of the optic nerve afferents in the rat suprachiasmatic nucleus (SCN) postsynaptic density (PD) material is added to existing symmetrical and asymmetrical appositions of non-optic synapses on optic target neurons. If the correlation between thickness of the postsynaptic density and excita...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90056-7

    authors: Güldner FH,Ingham CA

    更新日期:1980-04-01 00:00:00

  • Facilitation of supplementary motor area excitability improves dual-task walking in young adults.

    abstract::Activations of the DLPFC and SMA have been shown to correlate with dual-task walking. However, very few investigations have directly perturbed the activations of these areas to establish a cause-and-effect relationship. The objectives of this study were: 1) to investigate the role of DLPFC and SMA in dual-task walking...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.01.004

    authors: Goh HT,Ewing S,Marchuk D,Newton A,Nyangani I

    更新日期:2019-04-17 00:00:00

  • Duration of untreated illness as a key to early intervention in schizophrenia: A review.

    abstract::The first psychotic episode is classically viewed as a critical period which management is important in determining the long-term outcome of the schizophrenia (SCZ). For this reason, the duration of untreated illness (DUI), defined as the interval between the onset of the psychiatric disorder and the administration of...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2016.10.003

    authors: Murru A,Carpiniello B

    更新日期:2018-03-16 00:00:00

  • Nervus terminalis in dogfish (Squalus acanthias, Elasmobranchii) carries tonic efferent impulses.

    abstract::Recordings from the intact nervus terminalis with a hook electrode or from a stump of the divided nerve with a suction electrode show a tonic, irregular discharge of broad, low frequency spikes in ca. 4-6 units. These nerve impulses are efferent from the brain. The mean frequency of discharge is not influenced by vari...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90074-0

    authors: Bullock TH,Northcutt RG

    更新日期:1984-02-10 00:00:00

  • Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia.

    abstract::Reduction of non-protein-bound iron (NPBI) using iron chelators may attenuate hypoxia-ischemia-induced reperfusion injury of the brain. This study investigated whether administration of low-dose deferoxamine and allopurinol, both having NPBI-chelating properties, reduced hypoxia-ischemia-induced NPBI formation in plas...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00303-6

    authors: Shadid M,Buonocore G,Groenendaal F,Moison R,Ferrali M,Berger HM,van Bel F

    更新日期:1998-05-22 00:00:00

  • NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX.

    abstract::The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non-N-methyl-D-aspartate (non-NMDA) receptor antagonist, on NMDA-independent epileptiform activity induced by Mg2(+)-free medium was studied in rat basolateral amygdala (BLA) neurons using intracellular recording techniques. Twenty to 30 min after s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90753-v

    authors: Gean PW

    更新日期:1990-10-30 00:00:00

  • Analysis of glucose metabolism of (18)F-FDG in major depression patients using PET imaging: Correlation of salivary cortisol and α-amylase.

    abstract::Current diagnosis of Major depressive disorder (MDD) depends on its clinical symptoms, not on the results of any laboratory examinations. Establishing biological markers for diagnosis of MDD is one of the most important problems to be solved in psychiatry practice. MDD patients (n=8) and a healthy control group (n=8) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.06.039

    authors: Wei K,Xue HL,Guan YH,Zuo CT,Ge JJ,Zhang HY,Liu BJ,Cao YX,Dong JC,Du YJ

    更新日期:2016-08-26 00:00:00

  • A20 protects neuronal apoptosis stimulated by lipopolysaccharide-induced microglial exosomes.

    abstract::LPS-induced microglial activation has a major influence on neuronal damage in the inflammatory process. Integral to this is the cellular and molecular interaction between microglia and neurons. Exosomes, a mediator of communication between cells, can transfer lipids, proteins and nucleic acids, affecting many donor an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.134480

    authors: Chen X,Qian B,Kong X,Hao J,Ye Y,Yang K,Xu T,Zhang F

    更新日期:2019-11-01 00:00:00

  • Central serotonergic S2 binding in Papio anubis measured in vivo with N-omega-[18F]fluoroethylketanserin and PET.

    abstract::N-omega-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in vivo within S2 recept...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90149-n

    authors: Moerlein SM,Perlmutter JS

    更新日期:1991-02-11 00:00:00

  • Mechanical and neural interactions between binaurally applied sounds in cat cochlear nerve fibers.

    abstract::Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90299-2

    authors: Murata K,Tanahashi T,Horikawa J,Funai H

    更新日期:1980-07-01 00:00:00

  • Peptidergic innervation of the mammalian sinus nodes: vasoactive intestinal polypeptide, neurotensin, substance P.

    abstract::By the use of the peroxidase--antiperoxidase (PAP) technique in the sinus node of several mammalian species, vasoactive intestinal polypeptide (VIP), neurotensin (NT) and substance P (SP) immunoreactive structures were detected. VIP and NT as well as SP immunoreactive fibers were found in close association to the vasc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90146-4

    authors: Weihe E,Reinecke M

    更新日期:1981-11-04 00:00:00

  • Intracellular recordings from two cell types in an in vitro preparation of the salamander olfactory epithelium.

    abstract::Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane po...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90527-x

    authors: Masukawa LM,Kauer JS,Shepherd GM

    更新日期:1983-01-31 00:00:00

  • Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats.

    abstract::Vascular alterations of peripheral nerves occuring after mechanical injury or in metabolic disorders are well described. It is thought that vascular endothelial growth factor (VEGF), a potent growth factor for angiogenesis, also plays an important role for regeneration of nervous tissue. We used a rat model of type I ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00064-6

    authors: Samii A,Unger J,Lange W

    更新日期:1999-03-12 00:00:00

  • Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus.

    abstract::Immobilization stress induced interleukin-1 beta (IL-1 beta) mRNA in the rat hypothalamus. IL-1 beta mRNA was induced at 30 min after the start of immobilization, reached a maximum at 60 min and then was still detected with a decreased level at 120 min. However, 240 min after the start of the immobilization, IL-1 beta...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90944-o

    authors: Minami M,Kuraishi Y,Yamaguchi T,Nakai S,Hirai Y,Satoh M

    更新日期:1991-02-25 00:00:00

  • Tissue calcium levels in CaCl2-induced myelopathy.

    abstract::CaCl2-induced myelopathy was produced in rats by the application of a solution of CaCl2 to exposed leptomeninges of lumbosacral spinal cord. Equal lengths of remote cervical and lumbar cord were removed at intervals following Ca2+ application. The total Ca2+ in tissue from lumbar cord was significantly elevated over a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90302-1

    authors: Happel RD,Banik NL,Balentine JD,Hogan EL

    更新日期:1984-08-31 00:00:00

  • Developmental expression of the transcription factor zif268 in rat brain.

    abstract::Changes in the distribution pattern of mRNA encoding the zif268 transcription factor (also referred to as NGFI-A, Krox-24 or EGR-1) were investigated by in situ hybridization histochemistry during postnatal rat brain development. Marked changes in zif268 expression patterns were seen in particular in the cerebral cort...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90737-4

    authors: Herms J,Zurmöhle U,Schlingensiepen R,Brysch W,Schlingensiepen KH

    更新日期:1994-01-03 00:00:00

  • Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism.

    abstract::Telmisartan is known to block angiotensin (Ang) II type-1 receptors (AT(1)R), and also activate peroxisome proliferator-activated receptor gamma (PPARgamma) signaling. Recently, PPARgamma has been implicated as a regulator of cellular proliferation and inflammatory responses. In the present study, we investigated the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.08.043

    authors: Haraguchi T,Takasaki K,Naito T,Hayakawa K,Katsurabayashi S,Mishima K,Iwasaki K,Fujiwara M

    更新日期:2009-10-30 00:00:00

  • MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis.

    abstract::Genome-wide analysis of miRNA expression has revealed increased levels of miR-144 in the brains of Alzheimer's disease (AD) patients. Nuclear factor erythroid 2-related factor 2 (NRF2), a potential target of miR-144, is a central regulator of antioxidant response, and plays an important role in glutathione (GSH) biosy...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.06.045

    authors: Zhou C,Zhao L,Zheng J,Wang K,Deng H,Liu P,Chen L,Mu H

    更新日期:2017-08-10 00:00:00