Abstract：
:Hrk, a regulator of cell death, belongs to the family of pro-apoptotic BH3-only proteins and is known to induce apoptosis in nerve tissue. We examined Hrk gene expression to clarify the role of BH3-only proteins in apoptosis of retinal ganglion cells (RGCs) after optic nerve transection in the adult rat. Reverse transcription-polymerase chain reaction showed that Hrk was up-regulated in retina from 12 h after axotomy, and continued to be elevated for 1 week. In situ hybridization histochemistry revealed that Hrk was expressed in a sub-population of axotomized RGCs. These results suggest that Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wakabayashi T,Kosaka J,Hommura Sdoi
10.1016/s0304-3940(01)02487-9keywords:
subject
Has Abstractpub_date
2002-01-25 00:00:00pages
77-80issue
2eissn
0304-3940issn
1872-7972pii
S0304394001024879journal_volume
318pub_type
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