Abstract:
:Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
De Leo ME,Borrello S,Passantino M,Palazzotti B,Mordente A,Daniele A,Filippini V,Galeotti T,Masullo Cdoi
10.1016/s0304-3940(98)00469-8subject
Has Abstractpub_date
1998-07-10 00:00:00pages
173-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394098004698journal_volume
250pub_type
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