Abstract:
:Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin in it. Hence, we aimed to evaluate the effect of rutin on 21days chronic unpredictable stress (CUS) mouse model. CUS led to a decline in locomotion & muscle coordination abilities, cognitive deficits, anxiety, and depression. These neurobehavioral outcomes were associated with neurodegeneration in the CA3 region of the hippocampus as found by H&E staining. Rutin efficiently rescued the CUS-induced behavioral deficits by reducing depression, anxiety, improving cognition, and locomotor & muscle coordination skills. Further, rutin treatment protected the CUS-induced hippocampal neuronal loss. This study establishes the neuroprotective effect of rutin in chronic stress.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Parashar A,Mehta V,Udayabanu Mdoi
10.1016/j.neulet.2017.04.058subject
Has Abstractpub_date
2017-08-24 00:00:00pages
65-71eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30370-1journal_volume
656pub_type
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