Abstract:
:We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean +/- SD; 2.65 +/- 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 +/- 1.94 mg/l, P < 0.01) than those in control group (4.16 +/- 1.69 mg/l). In addition, the epsilon4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Song H,Saito K,Seishima M,Noma A,Urakami K,Nakashima Kdoi
10.1016/s0304-3940(97)00558-2subject
Has Abstractpub_date
1997-08-15 00:00:00pages
175-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394097005582journal_volume
231pub_type
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