Association between AKT1 gene and Parkinson's disease: a protective haplotype.

abstract：:Although minocycline has been generally thought to have neuroprotective properties, the neuroprotective role of minocycline has not been investigated in the animal model of epilepsy. In this study, we investigated whether minocycline is neuroprotective against kainic acid (KA)-induced cell death through the caspase-de...

journal_title：Neuroscience letters

authors： Heo K,Cho YJ,Cho KJ,Kim HW,Kim HJ,Shin HY,Lee BI,Kim GW

更新日期：2006-05-08 00:00:00

abstract：:Plasma renin activity (PRA) was determined in plasma samples obtained approximately at 6-min intervals during consecutive non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) periods in rats chronically implanted with EEG electrodes, a brain thermistor, and an intracardiac catheter. PRA was low in ...

journal_title：Neuroscience letters

authors： Obál F Jr,Beranek L,Brandenberger G

更新日期：1994-09-26 00:00:00

abstract：:We are constantly exposed to symbols such as traffic signs, emoticons in internet communication, or other abstract representations of objects as well as, of course, the written words. However, aside from the word reading, little is known about the way our brain responds when we read non-lexical iconic symbols. By usin...

journal_title：Neuroscience letters

authors： Shin YW,Kwon JS,Kwon KW,Gu BM,Song IC,Na DG,Park S

更新日期：2008-05-16 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has been rediscovered as a hormone and immunomodulator as well as a proinflammatory cytokine. We investigated the expression of MIF protein and mRNA in the rat brain using optimized immunohistochemistry and in situ hybridization, respectively. By immunohistochemical analysi...

journal_title：Neuroscience letters

authors： Ogata A,Nishihira J,Suzuki T,Nagashima K,Tashiro K

更新日期：1998-05-01 00:00:00

abstract：:The nitric oxide (NO)-cGMP signaling system and cAMP system play critical roles in the formation of multiple-trial induced, protein synthesis-dependent long-term memory (LTM) in many vertebrates and invertebrates. The relationship between the NO-cGMP system and cAMP system, however, remains controversial. In honey bee...

journal_title：Neuroscience letters

authors： Matsumoto Y,Hatano A,Unoki S,Mizunami M

更新日期：2009-12-25 00:00:00

abstract：:The ability in vivo of the muscarinic agonist, pilocarpine, to increase phosphoinositol (PI) hydrolysis in lithium pretreated rats was investigated by measuring the accumulation of [(3)H]inositol phosphates (IP). As expected, 20 mg/kg s.c. pilocarpine, a muscarinic agonist, increased PI hydrolysis in the striatum, fro...

journal_title：Neuroscience letters

authors： Johnson MP,Kelly GM,Chamberlain M

更新日期：2000-05-05 00:00:00

abstract：:This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. Rats were tested for aversion to the saccharin as measured by flavor consumption and orofacial reactions in the taste reactivity (TR) test. It was found that intraperitoneal...

journal_title：Neuroscience letters

authors： Soto A,Gasalla P,Begega A,López M

更新日期：2017-04-24 00:00:00

abstract：:Ischemic preconditioning is considered to be the most robust endogenous neuroprotectant. However, the conventional ischemic preconditioning protocol is both invasive and impractical to apply. The aim of the present study was to evaluate whether preconditioning with +Gz centrifuge acceleration (head-to-foot inertial lo...

journal_title：Neuroscience letters

authors： Sang H,Li J,Liu J,Wang Z,Huo T,Sun J,Xiong L

更新日期：2008-11-07 00:00:00

abstract：:The three tracers horseradish peroxidase (HRP), 4',6-diamidino-2-phenylindol-2HCl (DAPI) and Fast Blue (FB) differ in retrograde labeling of striato-nigral neurons. After a 24 h survival, injection of DAPI into the ventral tegmentum labeled numerous cells throughout the neostriatum, whereas an identical amount of HRP ...

journal_title：Neuroscience letters

authors： Frotscher M,Wagner A,Misgeld U

更新日期：1983-07-29 00:00:00

abstract：:Thioredoxin (TRX) is a small, multifunctional protein with a redox-active site and multiple biological functions that include reducing activity for reactive oxygen intermediates. We assayed TRX by immunohistochemical methods in the rat brain after intraperitoneal injection of 3-nitropropionic acid (3-NP), an irreversi...

journal_title：Neuroscience letters

authors： Sugino T,Nozaki K,Takagi Y,Hattori I,Hashimoto N,Yodoi J

更新日期：1999-11-12 00:00:00

abstract：:Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

journal_title：Neuroscience letters

authors： Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2001-01-26 00:00:00

abstract：:Functioning of the hypothalamo-pituitary-adrenocortical axis was assessed in rats treated with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), a selective noradrenergic neurotoxin. Although adrenal weights were slightly increased 10 days after DSP-4 injection, basal plasma corticosterone levels were unaltered co...

journal_title：Neuroscience letters

authors： Dooley DJ,Hunziker G,Häusler A

更新日期：1984-05-18 00:00:00

abstract：:Brain derived neurotrophic factor (BDNF), known to promote survival of neurons, has recently been involved in the regulation of endothelial cells and was shown to possess immunoregulatory properties. We therefore asked whether BDNF has immunoregulating effects in human cerebral endothelial cells (HCEC). Adult HCEC exp...

journal_title：Neuroscience letters

authors： Ruprecht K,Stadelmann C,Hummel V,Klein O,Brück W,Rieckmann P

更新日期：2002-09-20 00:00:00

abstract：:Rats with their intra-lingual taste nerves (the chorda tympani and the glossopharyngeal nerve) sectioned were trained to avoid drinking 0.5 M NaCl solution by associating NaCl drinking with subsequent LiCl poisoning. The acquired learned aversion in these rats was abolished after ablations of the neocortical area for ...

journal_title：Neuroscience letters

authors： Yamamoto T,Takahashi T,Kawamura Y

更新日期：1981-07-02 00:00:00

abstract：:The contribution of the circadian pacemaker and the sleep homeostat to sleep tendency and consolidation was quantified by forced desynchrony of the sleep-wake cycle from the circadian pacemaker in eight men who lived in time-isolation for 33-36 days. Analysis of 175 polygraphically recorded sleep episodes revealed tha...

journal_title：Neuroscience letters

authors： Dijk DJ,Czeisler CA

更新日期：1994-01-17 00:00:00

abstract：:Using immunohistochemical techniques, we demonstrate aspartate aminotransferase (AAT)-like immunoreactivity in cone pedicles and ganglion cells of the cat retina. An identical pattern was seen when we stained for cytochrome oxidase activity, a marker for neurons which have a high metabolic activity. Tetrodotoxin selec...

journal_title：Neuroscience letters

authors： Bolz J,Thier P,Brecha N

更新日期：1985-02-04 00:00:00

abstract：:The present study examined perception of individual finger forces during multi-finger force production tasks. In an ipsilateral force matching paradigm, 12 healthy subjects were instructed to produce a reference force pre-determined at 30% MVC of involved fingers (varying from 1 to 4 fingers, visual feedback of total ...

journal_title：Neuroscience letters

authors： Li S

更新日期：2006-12-06 00:00:00

abstract：:Expression by rat motoneurons of mRNAs for the alpha subunit of the ciliary neurotrophic factor receptor (CNTFR alpha), receptor tyrosine kinase-C (trkC), calcitonin gene-related peptide (CGRP) and galanin was studied by in situ hybridisation, 6d after rat facial nerve transection on postnatal day 1. Similar numbers o...

journal_title：Neuroscience letters

authors： Duberley RM,Johnson IP

更新日期：1996-11-08 00:00:00

abstract：:The aim of the present study was to assess reorganization in the motor cortex of patients with lower limb amputation. We studied seven patients with traumatic lower limb amputation, and six healthy controls, using transcranial magnetic stimulation mapping, with recordings from the quadriceps femoris muscle on both sid...

journal_title：Neuroscience letters

authors： Schwenkreis P,Pleger B,Cornelius B,Weyen U,Dertwinkel R,Zenz M,Malin JP,Tegenthoff M

更新日期：2003-10-09 00:00:00

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octa...

journal_title：Neuroscience letters

authors： Markstein R,Stöckli KA,Reubi JC

更新日期：1989-09-25 00:00:00

abstract：:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

journal_title：Neuroscience letters

authors： Chamas F,Serova L,Sabban EL

更新日期：1999-06-04 00:00:00

abstract：:We report positron emission tomographic measurements of regional cerebral blood flow (rCBF) in a male patient with war and torture related post-traumatic stress disorder (PTSD) during symptom provocation. The subject was exposed to war related sounds before and after treatment with a selective serotonin reuptake inhib...

journal_title：Neuroscience letters

authors： Fernandez M,Pissiota A,Frans O,von Knorring L,Fischer H,Fredrikson M

更新日期：2001-01-12 00:00:00

abstract：:To determine whether a trans-synaptic mechanism triggered the effects of reserpine on adrenomedullary mRNAs encoding the norepinephrine transporter and tyrosine hydroxylase, we administered 10 mg/kg reserpine to rats after unilateral splanchnicotomy, and examined their adrenal medullas using quantitative in situ hybri...

journal_title：Neuroscience letters

authors： Cubells JF,Baker H,Volpe BT,Smith GP,Das SS,Joh TH

更新日期：1995-07-07 00:00:00

abstract：:Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 microW/cm2; moderate, 420 microW/cm2; high, 1040 microW/cm2) red light during the middle of the night. High intensity red light (1040 microW/cm2) was as e...

journal_title：Neuroscience letters

authors： Sun JH,Yaga K,Reiter RJ,Garza M,Manchester LC,Tan DX,Poeggeler B

更新日期：1993-01-04 00:00:00

abstract：:After short periods of intense sympathetic activation, the action of the vagus nerve on heart rate is inhibited for periods of many minutes to several hours. This effect is not abolished by effective blockade of alpha- or beta-adrenoceptors and is not duplicated by administration of noradrenaline or isoprenaline. A si...

journal_title：Neuroscience letters

authors： Potter EK

更新日期：1985-03-15 00:00:00

abstract：:The cells of origin of the brainstem projection to the caudate-putamen (CP) were examined in the albino rat by the use of two fluorescent retrograde tracers. Nuclear yellow was injected into the CP of one hemisphere and granular blue was injected into the contralateral CP. Retrogradely labeled cells were studied in th...

journal_title：Neuroscience letters

authors： Loughlin SE,Fallon JH

更新日期：1982-09-20 00:00:00

abstract：:Previous neuroimaging studies raised the hypothesis that enhanced activity in the ipsilateral motor cortex (M1) plays a contributing role in the compensation for the motor deficits resulting from a spinal cord injury (SCI). However, it is still unknown whether the activity in the ipsilateral M1 directly contributes to...

journal_title：Neuroscience letters

authors： Nardone R,Höller Y,Höller P,Thon N,Thomschewski A,Brigo F,Trinka E

更新日期：2013-09-27 00:00:00

abstract：:An optimized clinical functional magnetic resonance imaging (fMRI) protocol with a total scanning time of 8 min is presented that localizes Broca's and Wernicke's areas robustly and determines hemispheric dominance. Language function was visualized using two different sentence generation (SG) and word generation (WG) ...

journal_title：Neuroscience letters

authors： Stippich C,Mohammed J,Kress B,Hähnel S,Günther J,Konrad F,Sartor K

更新日期：2003-07-31 00:00:00

abstract：:Mild cognitive impairment (MCI) is a nosological entity proposed as an intermediate state between normal aging and dementia. MCI seems to represent an early stage of Alzheimer's disease (AD) and there is a great interest in the relationship between MCI and the progression to AD. Some studies have demonstrated an accum...

journal_title：Neuroscience letters

authors： Padurariu M,Ciobica A,Hritcu L,Stoica B,Bild W,Stefanescu C

更新日期：2010-01-18 00:00:00