Abstract:
:Endothelin-1 (ET-1) is a potent vasoconstrictor that causes hypoperfusion of the neurosensory retina. We investigated immunohistochemically the expression of the receptors for ET-1, ET(A) and ET(B), in control and locally detached retinas of the pig. Immunoreactivity for ET(A) was expressed in the innermost retinal layers and in the outer plexiform layer in control retinas, and was additionally strongly expressed by retinal blood vessels at 7 days after detachment of the sensory retina from the pigment epithelium. Immunoreactivity for ET(B) was expressed by the innermost retinal layers, by ganglion cell somata, and by Müller glial cells in the control tissue, and was not altered in its expression after detachment. The vascular expression of ET(A) may suggest a hypoperfusion of the retina after detachment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Iandiev I,Uhlmann S,Pietsch UC,Biedermann B,Reichenbach A,Wiedemann P,Bringmann Adoi
10.1016/j.neulet.2005.04.056keywords:
subject
Has Abstractpub_date
2005-08-12 00:00:00pages
72-5issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00470-2journal_volume
384pub_type
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