Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea.

Abstract:

:Contraction of the isolated tracheal strip to capsaicin was prevented by chronic denervation of the tissue. Tetrodotoxin, hyoscine and hexamethonium caused no inhibition of the response, suggesting that tetrodotoxin-resistant terminal portions of non-cholinergic nerves were activated in this way. There was a strong correlation between the pain-producing and tracheoconstrictor effects of piperine, pungent and non-pungent capsaicin congeners. Common site of action was evidenced by crossed tachyphylaxis. It is concluded that the capsaicin-sensitive sensory nerve endings have a dual sensory-efferent function. Excitation-secretion coupling in this system could operate without an axon reflex.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Szolcsányi J

doi

10.1016/0304-3940(83)90426-3

subject

Has Abstract

pub_date

1983-11-21 00:00:00

pages

83-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(83)90426-3

journal_volume

42

pub_type

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