Acute membrane responses to viral action.

abstract：:The functional contribution of cloned subunits to insect nicotinic acetylcholine (ACh) receptors has been difficult to determine using heterologous expression. Instead, in this study we explore the subunit composition of naturally expressed functional receptors in an insect using RNA interference. The nicotinic alpha ...

journal_title：Neuroscience letters

authors： Vermehren A,Qazi S,Trimmer BA

更新日期：2001-11-09 00:00:00

abstract：:We recently reported here that SNCA triplication results in a doubling in the amount of alpha-synuclein protein in blood from cases with hereditary Lewy body disease. This observation shows that alpha-synuclein levels in blood accurately reflect gene dosage, which we assume drives pathogenesis in these individuals. A ...

journal_title：Neuroscience letters

authors： Miller DW,Crawley A,Gwinn-Hardy K,Lopez G,Nussbaum R,Cookson MR,Singleton AB,Hardy J,Dogu O

更新日期：2005-02-21 00:00:00

abstract：:Using a reproducible two-vessel occlusion model for forebrain ischemia in rats, we investigated the temporal and spatial changes of vascular endothelial growth factor (VEGF) expression after transient forebrain ischemia with Northern blot analysis and in situ hybridization. Northern blot analysis revealed that VEGF mR...

journal_title：Neuroscience letters

authors： Lee MY,Ju WK,Cha JH,Son BC,Chun MH,Kang JK,Park CK

更新日期：1999-04-16 00:00:00

abstract：:Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sproutin...

journal_title：Neuroscience letters

authors： You J,Hong SQ,Zhang MY,Zhao HL,Liu TZ,Zhou HL,Cai YQ,Xu ZM,Guo Y,Jiang XD,Xu RX

更新日期：2012-09-13 00:00:00

abstract：:Fatigue of the lumbar extensor muscles has been associated with a degradation of balance, but the mechanism is not well understood. The ankle plays a major role in upright standing, and loss of proprioceptive acuity at the ankle could contribute to a degradation of balance. Therefore, the first objective of this study...

journal_title：Neuroscience letters

authors： Pline KM,Madigan ML,Nussbaum MA,Grange RW

更新日期：2005-12-16 00:00:00

abstract：:In vivo differential pulse voltammetry with carbon fiber electrodes was used to monitor extracellular 5-hydroxyindoleacetic acid (5-HIAA) levels in a serotonergic denervated target area, the striatum, before and after transplantation of mesencephalic raphé nuclei into the lateral ventricle in the rat. The amplitude of...

journal_title：Neuroscience letters

authors： McRae-Degueurce A,Serrano A,Sandillon F,Privat A,Scatton B

更新日期：1984-07-27 00:00:00

abstract：:The antinociceptive action of cannabinoids in acute and inflammatory pain states have been well-documented. There is also accumulating evidence suggesting that cannabinoids are effective analgesics in chronic pain conditions. WIN 55,212-2, a mixed CB1 and CB2 cannabinoid receptor agonist, has been shown to be effectiv...

journal_title：Neuroscience letters

authors： Ulugol A,Karadag HC,Ipci Y,Tamer M,Dokmeci I

更新日期：2004-11-23 00:00:00

abstract：:The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neu...

journal_title：Neuroscience letters

authors： Mori H,Arai T,Ishii H,Adachi T,Endo N,Makino K,Mori K

更新日期：1998-01-30 00:00:00

abstract：:Adult monkeys who have been under training over a long period of time show a loss of the M2 component in their biceps electromyographic response to brief, random perturbations of an alternating arm movement, the M1 component being apparently enhanced. These changes of the stretch-induced responses indicate a long-term...

journal_title：Neuroscience letters

authors： Christakos CN,Wolf H,Meyer-Lohmann J

更新日期：1983-11-11 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are widely used in regeneration and repair of various tissues and organs, and whether MSC-conditioned medium (MSC-CM) has protective effects in postoperative cognitive dysfunction (POCD) remains largely unknown. We aimed to assess the therapeutic effect and explore the mechanisms...

journal_title：Neuroscience letters

authors： Jiang Y,Gao H,Yuan H,Xu H,Tian M,Du G,Xie W

更新日期：2019-09-14 00:00:00

abstract：:An increase in the number of cells undergoing apoptosis was observed in the cingulate sulcus of newborn piglets 48 h after a global hypoxic-ischaemic insult. Apoptotic death was identified morphologically (by light and electron microscopy) and by DNA fragmentation, detected by in situ end labelling. The number of apop...

journal_title：Neuroscience letters

authors： Mehmet H,Yue X,Squier MV,Lorek A,Cady E,Penrice J,Sarraf C,Wylezinska M,Kirkbride V,Cooper C

更新日期：1994-11-07 00:00:00

abstract：:Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and hav...

journal_title：Neuroscience letters

authors： Kang W,Sun Z,Zhao X,Wang X,Tao Y,Wu H

更新日期：2019-09-14 00:00:00

abstract：:The KIBRA gene encodes a cytoplasmatic protein, a member of the signal transduction protein family, expressed mainly in the brain. Recent studies have implicated the involvement of a genetic variation in the KIBRA gene (T allele) in human memory in normal subjects and in the risk of developing Alzheimer's disease (AD)...

journal_title：Neuroscience letters

authors： Nacmias B,Bessi V,Bagnoli S,Tedde A,Cellini E,Piccini C,Sorbi S,Bracco L

更新日期：2008-05-09 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies demonstrated that oxidative damage decreased intracellular ATP level in astrocytes. However, the pathway mediated ATP level decrease is obscure. Our previous study found intracellular ATP could be released via lysosome exocytosis in astrocytes. Here, we explored whether lysosome exocytosi...

journal_title：Neuroscience letters

authors： Li Z,Gu Y,Wen R,Shen F,Tian HL,Yang GY,Zhang Z

更新日期：2019-07-13 00:00:00

abstract：:In addition to providing structural, metabolic and trophic support to neurons, glial cells of the central, peripheral and enteric nervous systems (CNS, PNS, ENS) respond to and regulate neural activity. One of the most well characterized features of this response is an increase of intracellular calcium. Astrocytes at ...

journal_title：Neuroscience letters

authors： Heredia DJ,De Angeli C,Fedi C,Gould TW

更新日期：2020-06-11 00:00:00

abstract：:Recordings from the intact nervus terminalis with a hook electrode or from a stump of the divided nerve with a suction electrode show a tonic, irregular discharge of broad, low frequency spikes in ca. 4-6 units. These nerve impulses are efferent from the brain. The mean frequency of discharge is not influenced by vari...

journal_title：Neuroscience letters

authors： Bullock TH,Northcutt RG

更新日期：1984-02-10 00:00:00

abstract：:The intracerebroventricular injection of the mast cell degranulator, compound 48/80 (C48/80, 10 micrograms/kg), produced a marked behavioural syndrome in rats which included head and body shakes, paw tremor, excessive grooming, unusual posture and gait, mild diarrhoea, piloerection, extreme agitation and irritability ...

journal_title：Neuroscience letters

authors： Lewis SJ,Quinn MJ,Fennessy MR,Jarrott B

更新日期：1986-03-28 00:00:00

abstract：:The type of glass used to fabricate patch pipettes influences the kinetic properties of single-channel currents activated by acetylcholine in Xenopus myocytes. In patches formed with hard glass pipettes, the opening rate decreased in a time-dependent manner. Such decrease was most pronounced for the low-conductance ch...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1988-05-16 00:00:00

abstract：:This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

journal_title：Neuroscience letters

authors： Motl RW,Knowles BD,Dishman RK

更新日期：2003-08-21 00:00:00

abstract：:Lesion-induced degeneration was combined with immunocytochemistry to study, with electron microscopy, the synaptic connectivity between corticothalamic axon terminals from the first and second somatosensory areas and local circuit neurons of the ipsilateral ventrobasal complex (VB), selectively labelled with an antibo...

journal_title：Neuroscience letters

authors： Barbaresi P,Manzoni T

更新日期：2003-03-27 00:00:00

abstract：:The present study investigated in vivo the kinetic of the changes in rat striatal extracellular concentrations of dopamine (DA), and its monoamine oxidase (MAO)-derived metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), following administration either of nitric oxide (NO) synthase (NOS) inhibitors 7-nitroindazole (7-N...

journal_title：Neuroscience letters

authors： Desvignes C,Bert L,Vinet L,Denoroy L,Renaud B,Lambás-Señas L

更新日期：1999-04-02 00:00:00

abstract：:The localization of serotonin and non-serotonin-containing cell bodies in the interpeduncular nucleus of the rat that project to the hippocampal formation was studied using the technique of retrograde tracing of Granular Blue and immunohistochemistry on the same sections. The results indicate that the caudal magnocell...

journal_title：Neuroscience letters

authors： Groenewegen HJ,Steinbusch HW

更新日期：1984-09-28 00:00:00

abstract：:To demonstrate the preference of lactate over glucose as an energy substrate in normal brain tissue under normoxic condition, the dynamic changes in glucose uptake by lactate loading were investigated in living rat brain slices using a positron autoradiography technique. Fresh rat brain slices were incubated with [18F...

journal_title：Neuroscience letters

authors： Murata T,Waki A,Omata N,Fujibayashi Y,Sadato N,Yano R,Yoshimoto M,Isaki K,Yonekura Y

更新日期：1998-06-19 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (...

journal_title：Neuroscience letters

authors： Pu Y,Chang L,Qu Y,Wang S,Tan Y,Wang X,Zhang J,Hashimoto K

更新日期：2020-06-21 00:00:00

abstract：:The activities of RNA-dependent DNA polymerase and DNA-dependent DNA polymerase were measured in hippocampus of fast and slow learning Wistar rats. The RNA-dependent DNA polymerase activity in the hippocampus of fast learning rats exceeds two-fold that in the slow learning ones, while the rates of the DNA-dependent DN...

journal_title：Neuroscience letters

authors： Salganik RI,Parvez H,Tomsons VP,Shumskaya IA

更新日期：1983-04-29 00:00:00

abstract：:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The c...

journal_title：Neuroscience letters

authors： Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike N

更新日期：1990-05-31 00:00:00

abstract：:It is well established that neurons in the dorsal medulla, including the area postrema and the medial nucleus tractus solitarius (mNTS), are involved in the central actions of circulating peptides such as angiotensin II (ANG II) and arginine vasopressin (AVP). This report describes a preparation that permits the ident...

journal_title：Neuroscience letters

authors： Hay M,Edwards GL,Lindsley K,Murphy S,Sharma RV,Bhalla RC,Johnson AK

更新日期：1993-03-19 00:00:00

abstract：:We investigated changes in the corticospinal pattern of activity in healthy volunteers during sustained noxious and non-noxious mechanical stimulation of the first hand digit, resulting from active (self-stimulation) or passive (externally-induced) pressing against a sharp or blunted tip. The results indicate that, in...

journal_title：Neuroscience letters

authors： Fadiga L,Craighero L,Dri G,Facchin P,Destro MF,Porro CA

更新日期：2004-05-06 00:00:00

abstract：:The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis...

journal_title：Neuroscience letters

authors： Nozawa Y,Nishihara K,Yamamoto A,Nakano M,Ajioka H,Matsuura N

更新日期：2001-08-17 00:00:00

abstract：:Protein kinase G (PKG) has been implicated in a variety of physiological functions including synaptic plasticity in the brain. This study investigated the involvement of dopamine D3 (D3) receptors in PKG-regulated dopamine release, long-term changes in gene expression and behavioral sensitization after repeated cocain...

journal_title：Neuroscience letters

authors： Lee DK,Oh JH,Yang JH,Youn B,Shim YB,Shim I,Wang JQ,Choe ES

更新日期：2013-04-29 00:00:00