Abstract:
:We have used the polyoma middle T oncogene to immortalize cells from rat embryo encephalon. Immunostaining experiments with monoclonal antibodies demonstrated that the cells of one of the obtained lines, named CEINGE CL3, are stained by anti-vimentin and anti-S100 antibodies, are not stained by anti-neurofilaments (NF) or anti-glial fibrillary acidic-protein (GFAP) antibodies. Only a subset of the CEINGE CL3 cells (20-30%) is stained by an anti-galactocerebroside antibody. Northern blot analysis demonstrated that these cells express low levels of proteolipid protein mRNA, whereas polymerase chain reaction (PCR) amplification failed to evidentiate the presence of both NF and GFAP mRNAs. Either retinoic acid or forskolin treatments or a combination of them are able to induce morphological changes that are accompanied by a complete growth arrest.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Russo T,Mogavero AR,Ammendola R,Mesuraca M,Fiore F,Fatatis A,Salvatore G,Cimino Fdoi
10.1016/0304-3940(93)90823-4subject
Has Abstractpub_date
1993-09-03 00:00:00pages
159-62issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90823-4journal_volume
159pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:2012-06-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1993-09-03 00:00:00
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journal_title:Neuroscience letters
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