Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

abstract：:A highly significant endogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [3H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, whi...

journal_title：Neuroscience letters

authors： Schneider LH,Murphy RB,Coons EE

更新日期：1982-12-13 00:00:00

abstract：:Novel paired ependymal ridges (EPRS) have been identified in the ventrolateral wall of the cerebral aqueduct of the rat. Scanning electron microscopic techniques revealed that the dorsolateral and ventromedial ridges differ from each other in surface morphology. Using the PAP immunohistochemical technique, the EPRS de...

journal_title：Neuroscience letters

authors： Welsh MG,Beitz AJ

更新日期：1981-11-18 00:00:00

abstract：:Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prosta...

journal_title：Neuroscience letters

authors： Tringali G,Vairano M,Dello Russo C,Preziosi P,Navarra P

更新日期：2004-01-09 00:00:00

abstract：:Anatomical relationships of hypothalamic cocaine- and amphetamine-regulated transcript (CART) with other hypothalamic neuropeptides were examined by using in situ hybridization histochemistry and immunohistochemistry. CART mRNA was found in various regions in rat hypothalamus, including the periventricular nucleus, pa...

journal_title：Neuroscience letters

authors： Li HY,Hwang HW,Hu YH

更新日期：2002-05-03 00:00:00

abstract：:The anti-neuroinflammatory effect of Astragaloside IV (ASI) has been reported, but its underlying mechanisms are unclear. This study is further to explore the underlying mechanism of ASI on anti-neuroinflammatory effect in LPS induced microglia cells. The result showed ASI significantly reduced the production of infla...

journal_title：Neuroscience letters

authors： Li C,Yang F,Liu F,Li D,Yang T

更新日期：2018-02-14 00:00:00

abstract：BACKGROUND:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a subcortical, inherited, cerebral small vessel disease. Several studies have revealed the involvement of specific cortical regions. However, the structural brain alterations and their clinical correlation...

journal_title：Neuroscience letters

authors： Pan H,Huang Q,Ban S,Du X,Su J,Liu J

更新日期：2020-11-01 00:00:00

abstract：:The present study evaluates the hypotheses that a GABAergic mechanism underlies neurobehavioral sequelae of carotid stenosis and that it can be reversed by carotid revascularization. We used the Rivermead Behavioural Memory Test (RBMT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), ...

journal_title：Neuroscience letters

authors： Murata K,Fujiki M,Ooba H,Kubo T,Morishige M,Abe T,Ishii K,Kobayashi H,Kiyosue H,Mori H

更新日期：2011-08-18 00:00:00

abstract：:Circadian firing rhythms of cultured rat suprachiasmatic nucleus were measured simultaneously from 4-8 neurons by using a multi-electrode dish and neuronal interactions were examined by a cross-correlation analysis of spontaneous action potentials. Functional connections were detected in the neuron pairs showing synch...

journal_title：Neuroscience letters

authors： Honma S,Shirakawa T,Nakamura W,Honma K

更新日期：2000-11-17 00:00:00

abstract：:The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally diverse spinocerebellar ataxia genes have been identified. The main question that remains yet unsolved is why do some many genetic insults lea...

journal_title：Neuroscience letters

authors： Huang M,Verbeek DS

更新日期：2019-01-01 00:00:00

abstract：:Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin...

journal_title：Neuroscience letters

authors： Parashar A,Mehta V,Udayabanu M

更新日期：2017-08-24 00:00:00

abstract：:Cultured rat pheochromocytoma cells, PC-12, were found to contain renin-like activity. The activity which was inhibited by monospecific antibodies to rat renal renin showed a pH optimum between 6 and 7, indicating that it was a specific renin. The cells also contained angiotensin I and angiotensin I converting enzyme....

journal_title：Neuroscience letters

authors： Okamura T,Clemens DL,Inagami T

更新日期：1984-05-04 00:00:00

abstract：:Mutations in DJ-1 cause familial Parkinson's disease (PD). The expression pattern of DJ-1 in the brain remains controversial. In the present study, we used DJ-1 deficient mice as negative controls and examined DJ-1 mRNA expression in mouse brains. In sequential double labeling on the same sections, in situ hybridizati...

journal_title：Neuroscience letters

authors： Xie Z,Zhuang X,Chen L

更新日期：2009-11-20 00:00:00

abstract：:The intracellular stress-induced proteins provide protection against toxic insults. Here, a 60,000-Da heat shock 60 (hsp60)-like protein was detected, with five different antibodies, in conditioned media derived from rat cortical astrocytes and a human neuroblastoma cell line. Extracellular neuroblastoma hsp60-like im...

journal_title：Neuroscience letters

authors： Bassan M,Zamostiano R,Giladi E,Davidson A,Wollman Y,Pitman J,Hauser J,Brenneman DE,Gozes I

更新日期：1998-06-26 00:00:00

abstract：:The actions of huperzine A (HupA), a novel cholinesterase inhibitor, on the sustained potassium current were investigated in acutely dissociated hippocampal neurons of rat. HupA inhibited the current (IC(50) = 856 +/- 1 microM) with voltage-dependency. The effect was insensitive to 3 microM atropine. Tacrine (IC(50) =...

journal_title：Neuroscience letters

authors： Li Y,Hu GY

更新日期：2002-08-30 00:00:00

abstract：:Impaired energy metabolism plays an important role in neuronal cell death after brain ischemia, and apoptosis has been implicated in cell death induced by metabolic impairment. In the present study, metabolic impairment was induced by 3-nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase. ...

journal_title：Neuroscience letters

authors： Sugino T,Nozaki K,Tokime T,Hashimoto N,Kikuchi H

更新日期：1997-11-21 00:00:00

abstract：INTRODUCTION:The saccadic paradigm has been used to investigate specific cortical networks involving attention. The behavioral and electrophysiological investigations of the SEM contribute significantly to the understanding of attentive patterns presented of neurological and psychiatric disorders and sports performance...

journal_title：Neuroscience letters

authors： Bittencourt J,Machado S,Teixeira S,Schlee G,Salles JI,Budde H,Basile LF,Nardi AE,Cagy M,Piedade R,Sack AT,Velasques B,Ribeiro P

更新日期：2012-08-15 00:00:00

abstract：:The critical period for observing a developmentally regulated form of synaptic plasticity in the visual cortex of young rats normally ends at about postnatal day 30. This developmentally regulated form of in vitro long-term potentiation (LTP) can be reliably induced in layers II-III by aiming high frequency, theta bur...

journal_title：Neuroscience letters

authors： Shaffery JP,Lopez J,Bissette G,Roffwarg HP

更新日期：2006-01-02 00:00:00

abstract：:The content of synaptophysin, a vesicular integral membrane protein of neurons and endocrine cells, and that of vasopressin was measured in neurohypophyses of rats during chronic osmotic stimulation. The animals received 2% NaCl in their drinking water for up to 4 days. Synaptophysin content of neurohypophyses was det...

journal_title：Neuroscience letters

authors： Ehrhart-Bornstein M,Thorn NA,Treiman M

更新日期：1990-10-30 00:00:00

abstract：:Super-resolution microscopy techniques offer subdiffraction limited resolution that is two- to ten-fold improved compared to that offered by conventional confocal microscopy. This breakthrough in resolution for light microscopy has contributed to new findings in neuroscience and synapse biology. This review will focus...

journal_title：Neuroscience letters

authors： Badawi Y,Nishimune H

更新日期：2020-01-10 00:00:00

abstract：:A push-pull perfusion technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious rat. Ventricular perfusate contained significant quantities of vasopressin and oxytocin, 13.1 and 4.5 pg/ml, respectively. Vasopressin and oxytocin levels were stable over a 3 h perfusion period. High sodium...

journal_title：Neuroscience letters

authors： Barnard RR Jr,Morris M

更新日期：1982-04-26 00:00:00

abstract：:Visual P300 responses were recorded by using checkerboard-type stimuli. (1) High amplitude P300-delta responses were visible even in single trial event-related potentials (ERPs). (2) The algorithm based on the 'delta response metric' provides an efficient selection criterion for evaluation of P300 single trials in ERP...

journal_title：Neuroscience letters

authors： Schürmann M,Başar-Eroglu C,Kolev V,Başar E

更新日期：1995-09-15 00:00:00

abstract：:Tacrine (1,2,3,4-tetrahydro-9-acridinamine) inhibited binding of [3H]flunitrazepam to benzodiazepine receptors of guinea pig hippocampus with an inhibition constant of 46 microM at 2 degrees C and 37 degrees C. gamma-Aminobutyric acid (GABA) decreased the affinity of tacrine for the receptor, suggesting that tacrine m...

journal_title：Neuroscience letters

authors： Dawson RM,Poretski M

更新日期：1991-08-19 00:00:00

abstract：:The factors determining the large variation seen in human corpus callosum (CC) morphology are as yet unknown. In this study heritability of CC size was assessed by comparing the concordance of CC midsagittal area in 14 monozygotic and 12 dizygotic twin pairs with a mean age of 27 years, using magnetic resonance imagin...

journal_title：Neuroscience letters

authors： Scamvougeras A,Kigar DL,Jones D,Weinberger DR,Witelson SF

更新日期：2003-02-27 00:00:00

abstract：:Sorbitol accumulation and transmembrane efflux in JS1 schwannoma cells were examined during osmotic stress in the presence of a sorbitol dehydrogenase (SD) inhibitor and following return to iso-osmotic conditions. SD inhibition promoted sorbitol accumulation under hyperglycemic and/or hyperosmotic conditions, and sorb...

journal_title：Neuroscience letters

authors： Mizisin AP,Li L,Calcutt NA

更新日期：1997-06-20 00:00:00

abstract：:Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide that has been shown to cause peripheral sensitization of knee joint afferents; however, the effect of the peptide on joint pain behaviour is unknown. In addition to having a direct effect on peripheral nerves, N/OFQ has also been shown to activate connectiv...

journal_title：Neuroscience letters

authors： McDougall JJ,Larson SE

更新日期：2006-05-01 00:00:00

abstract：:Previous studies have extensively reported an advantage of females in empathy as compared with males. It remains to be clarified, however, whether these sex differences are associated with sex specific neural processes underlying empathic response to different intensity of emotional stimulus. The present study examine...

journal_title：Neuroscience letters

authors： Luo P,Zheng X,Chen X,Li Y,Wang J,Deng L,Zheng X

更新日期：2014-08-22 00:00:00

abstract：:Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (1H MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alter...

journal_title：Neuroscience letters

authors： Yoo CH,Song KH,Lim SI,Lee DW,Woo DC,Choe BY

更新日期：2017-01-10 00:00:00

abstract：:Pentobarbital anesthesia causes about a 10-fold increase in the antinociceptive potency of beta-endorphin microinjected into the periaqueductal gray (PAG) region of the rat brain. The antinociceptive response to PAG morphine was markedly attenuated during anesthesia, but returned as the rats regained consciousness. As...

journal_title：Neuroscience letters

authors： Smith DJ,Robertson B,Monroe PJ

更新日期：1992-11-09 00:00:00

abstract：:Senile plaques (SPs) and cerebral amyloid angiopathy (CAA) in the brains of five aged (20-26 years old) cynomolgus monkeys were investigated immunohistochemically using two monoclonal antibodies (anti-A beta 40 (BA27) and anti-A beta 42(43) (BC05)) that can differentiate the carboxyl termini of amyloid beta protein (A...

journal_title：Neuroscience letters

authors： Nakamura S,Tamaoka A,Sawamura N,Shoji S,Nakayama H,Ono F,Sakakibara I,Yoshikawa Y,Mori H,Goto N

更新日期：1995-12-08 00:00:00

abstract：:It is known that 5HTR2A (rs6311) receptors have high concentration in the cortical layer-5 pyramidal neurons and that these receptors play an important role in the modulation of neurocognitive functions. For example, layer-5 pyramidal neurons mediate cellular level integrative interaction of primary sensory afferent s...

journal_title：Neuroscience letters

authors： Maksimov M,Vaht M,Harro J,Bachmann T

更新日期：2015-01-01 00:00:00