Abstract:
:Experimental Scrapie in hamster is a simple, reproducible model of prion diseases that occur in humans and animals. Stereotaxic microinoculation (0.5 microliter) of the agent (263 K) into a specific cerebral structure (striatum) in hamster, previously developed in our group, gives the opportunity to further investigate the pathogenesis of these degenerative diseases and to more precisely define the brain areas and the groups of cells more vulnerable to the effects of the agent. In this model, early significant changes of glutamic acid decarboxylase (GAD) activity in striatum suggested a preferential alteration of the GABA system. The present study was focused on the effects of Scrapie agent directly injected into striatum on GABA neurons at the presynaptic level (GABA uptake) and at the postsynaptic level (GABAA receptors). The high-affinity [3H]GABA uptake is not changed in the Scrapie-injected striatum neither in the controlateral site and the kinetics (Km, Vmax) values are not statistically different for control and Scrapie-inoculated animals. The binding of [3H]GABA (Scatchard analysis) to cerebral membranes does not seem to be altered either at the local site of agent inoculation (striatum) neither at distance in the cerebellum: the affinity constant (Kd) to the ligand and the maximal number of receptor sites were of the same magnitude in control and Scrapie animals, but we do not have a statistical analysis. These effects are completely different of those of a neurotoxin. The present data suggest that the effects of prion agent may be very limited and very specific to some cellular mechanisms, without altering the whole cellular machinery, as recently shown in an in vitro model.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Grégoire N,Lebrun F,Fahn L,Salamon G,Nicoli Jdoi
10.1016/0304-3940(93)90366-ssubject
Has Abstractpub_date
1993-12-12 00:00:00pages
141-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90366-Sjournal_volume
163pub_type
杂志文章abstract::Neurotrophic factors regulate neuronal survival and differentiation and control neurite outgrowth by binding to tyrosine kinase receptors, the Trks, and a tumor necrosis factor (TNF) receptor-like molecule, p75 neurotrophin receptor. A proinflammatory cytokine, TNF, also affects survival and apoptotic death in neurona...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.09.031
更新日期:2006-01-16 00:00:00
abstract::The febrile responses induced by i.v. administrations of staphylococcal enterotoxin A (SEA) was mimicked by direct injection of SEA into the organum vasculosum laminae terminalis (OVLT) in unanesthetized rabbits. Compared with the febrile responses induced by i.v. injection of SEA, the OVLT route of injection required...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00759-3
更新日期:1997-10-24 00:00:00
abstract::In membrane physiology, as in other fields, myths or speculations may be repeated so often and so widely that they are perceived as facts. To some extent, this has occurred with regard to gap junctions, hemichannels, pannexin channels and P2X7 (ionotropic receptors), especially concerning the interpretation of the ind...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2017.11.044
更新日期:2019-03-16 00:00:00
abstract::We studied the trophic effects of various neuropeptides, including substance P (SP), thyrotropin-releasing hormone (TRH), neurotensin (NT) and bombesin (BN) on explanted cultures of ventral spinal cord from 13- to 14-day-old rat embryos. In groups, receiving one type of drug only, there was a significant neurite-promo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90552-1
更新日期:1989-07-03 00:00:00
abstract::The role of descending monoaminergic systems in the antinociceptive effect of kyotorphin (Tyr-Arg, KTP) was investigated in mice by means of the tail-pinch test. We compared this effect with that of the delta-opioid receptor agonist [D-Pen(2,5)]-enkephalin (DPDPE). The antinociceptive effect of KTP and DPDPE injected ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00647-x
更新日期:2002-08-30 00:00:00
abstract::The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, bu...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90171-6
更新日期:1987-11-10 00:00:00
abstract::The effects of morphine (0.2-200 micrograms/kg) administered into the brain stem via a vertebral artery on the somatosympathetic A- and C-reflexes evoked in a cardiac sympathetic nerve by electrical stimulation of somatic myelinated (A) and unmyelinated (C) afferent nerve fibers in anesthetized cats were examined. The...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90916-u
更新日期:1992-04-27 00:00:00
abstract::Rim is a multi-domain, active zone protein that regulates exocytosis and is implicated in vesicle priming and presynaptic plasticity. We recently demonstrated that synaptic defects associated with loss of Caenorhabditis elegans Rim (termed UNC-10) are accompanied by a reduction in docked vesicles adjacent to the presy...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.08.026
更新日期:2008-10-24 00:00:00
abstract::The placebo effect can be elicited by two main mechanisms: via classical conditioning and cognitive expectations. These two mechanisms have been traditionally investigated in one single domain. The aim of the present study is to investigate how a placebo effect obtained in one modality (pain tolerance) can be transfer...
journal_title:Neuroscience letters
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neulet.2016.08.046
更新日期:2016-10-06 00:00:00
abstract::Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13416-4
更新日期:1997-02-21 00:00:00
abstract:INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.07.022
更新日期:2008-09-12 00:00:00
abstract::Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regio...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.04.034
更新日期:2009-07-24 00:00:00
abstract::Tyrosine phosphorylation is an important means for regulating post-ischemic signal transduction. In this article, brain ischemia was induced by four-vessel occlusion, and the effect of ischemia/reperfusion on proline-rich tyrosine kinase 2 (Pyk2) was studied. Tyrosine phosphorylation of Pyk2 in Sprague-Dawley rat hipp...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00618-9
更新日期:2003-09-18 00:00:00
abstract::It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.12.007
更新日期:2018-02-05 00:00:00
abstract::Crickets (Gryllus bimaculatus) use the cercal sensory system at the rear of the abdomen to detect air currents and direct predator avoidance behavior. Sensory information regarding the direction and dynamic properties of air currents is processed within the terminal abdominal ganglion, and conveyed by ascending giant ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.10.042
更新日期:2015-01-01 00:00:00
abstract::Online shopping festivals play a significant role in consumers' purchase decision and have been the focus of much research and many marketing practices. However, research has yet to explore which product categories can promote consumer purchase intention during online shopping festivals. This study carried out a neuro...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.134665
更新日期:2020-01-10 00:00:00
abstract::Within the normal inner ear, there are elements that belong to the immune system. Different inner ear disorders can be explained by autoimmune mechanisms, affecting both humoral and cellular immunity. Melatonin, the principal hormone of the pineal gland, modulates the immune system and extensively participates in the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00844-6
更新日期:1997-11-28 00:00:00
abstract::Magnetic resonance imaging (MRI) of two pig brains was realized. The animals were placed in the stereotaxic conditions currently used in experiments. To allow the positioning of the animal in the MRI instrument, landmarks were previously traced on the snout of the pig. To avoid movements, animals were deeply anestheti...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90452-q
更新日期:1993-06-25 00:00:00
abstract::Intracellular recordings were used to examine the mechanisms underlying the 5-hydroxytryptamine (5-HT)4 receptor-mediated depolarization seen in CA1 region pyramidal cells in in vitro hippocampal brain slices. This depolarization was mimicked and occluded by administration of the membrane permeable cyclic adenosine mo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00113-1
更新日期:2002-05-10 00:00:00
abstract::It has been demonstrated that immunization of transgenic mouse models of Alzheimer's disease (AD) with amyloid-beta1-42 peptide (Abeta1-42) results in amelioration of AD-like pathology, including reduced soluble and deposited beta-amyloid and decreased cognitive impairment. Based on the proposed importance of immunogl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01951-6
更新日期:2001-07-13 00:00:00
abstract::Female Fischer 344 (F344) rats were tested for age-related differences in both cerebellar beta-adrenergic receptor activation and motor learning. Three and 20 month old rats were tested on a motor learning paradigm that required the rats to adjust their gait to navigate a runway of unevenly spaced pegs. Rates of acqui...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)13007-x
更新日期:1996-09-20 00:00:00
abstract::Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(78)90114-3
更新日期:1978-01-01 00:00:00
abstract::Sex differences in basal extracellular striatal dopamine concentrations in gonadectomized male and female rats have been reported previously. In the current experiment, estrous cycle-dependent variation, sex differences and the effect of gonadectomy on extracellular striatal dopamine concentrations were determined usi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90510-x
更新日期:1994-10-24 00:00:00
abstract::The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90299-9
更新日期:1983-09-30 00:00:00
abstract::The organotypic hippocampal slice culture technique was used to study how the effects of repeated ethanol withdrawal might differ between males and females at the cellular level, including potential modulation of subsequent insults. A chronic intermittent ethanol (CIE) exposure paradigm was employed, with 3 days of ex...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.05.011
更新日期:2013-08-29 00:00:00
abstract::Acetylcholinesterase (AChE) is an essential enzymatic component of the neuromuscular junction where it is responsible for terminating neurotransmission by the cholinergic motor neurons. The enzyme at the neuromuscular junction (NMJ) is contributed primarily by the skeletal muscle where it is produced at higher levels ...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2020.135157
更新日期:2020-09-14 00:00:00
abstract::Conduction velocities of antidromically evoked impulses along the goldfish Mauthner axon were found to be inversely correlated with body length. To test the hypothesis that such a relation is accompanied by a reduction in axonal diameter with increasing fish size, Mauthner axon diameters were measured. A parabolic rel...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90261-5
更新日期:1981-12-11 00:00:00
abstract::Bleedings in the ganglionic eminence (GE) being a prominent domain of the telencephalic proliferative zone is a frequent complication of preterm infants. Such bleedings may induce cellular responses in the vicinity of the lesion. Using immunohistochemistry, this study demonstrates for the first time that leukemia inhi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01778-x
更新日期:2001-02-16 00:00:00
abstract::Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were fo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(79)96073-7
更新日期:1979-05-01 00:00:00
abstract::Ample evidence has been reported to show a probable contribution of orexin in the central cardiovascular regulation. Although cardiovascular and respiratory centers in the brain are located close to each other and are interconnected, the possible participation of orexin in respiratory regulation has not been fully doc...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.05.032
更新日期:2005-09-09 00:00:00