Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases.

abstract：:A critical component of the cellular stress response, the p53 tumor suppressor protein must be functional for many cancer therapies to be effective. Adjuvant therapies that augment p53 function are predicted to sensitize tumor cells to cancer therapies that rely upon p53 for their efficacy. Of those strategies current...

journal_title：Neuroscience letters

authors： Ghassemifar S,Mendrysa SM

更新日期：2012-03-28 00:00:00

abstract：:Silver staining (Bodian procedure) in the nucleus of the sublenticular substantia innominata (SI), also referred to as the nucleus basalis of Meynert, was evaluated in autopsy material from patients with Alzheimer's disease or senile dementia of the Alzheimer type (age at death: mean 69 years, range 63 to 81 years; ti...

journal_title：Neuroscience letters

authors： Jacobs RW,Farivar N,Butcher LL

更新日期：1985-05-23 00:00:00

abstract：:In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocy...

journal_title：Neuroscience letters

authors： McQueen JK,Wright AK,Arbuthnott GW,Fink G

更新日期：1990-10-02 00:00:00

abstract：:Exposure to manganese in an industrial or clinical setting can lead to manganism, a neurological disorder with similarities to Parkinson's disease. Although the pathogenetic basis of this disorder is unclear, studies indicate this metal is highly accumulated in astrocytes, suggesting an involvement of these glial cell...

journal_title：Neuroscience letters

authors： Hazell AS,Normandin L,Norenberg MD,Kennedy G,Yi JH

更新日期：2006-04-03 00:00:00

abstract：:Antibodies to fibronectin (Fn) bind not only the basal lamina in Alzheimer's disease brain, but also crystal-like formations in the grey matter, senile plaques, a subset of neuronal perikarya, and large highly processed stellate formations which were both neurofilament and glial fibrillary acidic protein (GFAP) negati...

journal_title：Neuroscience letters

authors： Howard J,Pilkington GJ

更新日期：1990-10-02 00:00:00

abstract：:We compared the modulation of GABA (gamma-aminobutyric acid)-activated currents by benzodiazepines in recombinant GABAA receptors containing either one of two alpha subunits, alpha 1 or alpha 6. Lüddens et al. (Nature, 346 (1990) 648-651) have previously demonstrated that the alpha 6 subunit is part of a cerebellar re...

journal_title：Neuroscience letters

authors： Kleingoor C,Ewert M,von Blankenfeld G,Seeburg PH,Kettenmann H

更新日期：1991-09-16 00:00:00

abstract：:Cytochrome c oxidase (COX) is a key mitochondrial enzyme that catalyzes electron transfer at the terminal stage of respiratory chain and is composed of multisubunits. We hypothesize that ethanol withdrawal (EW) impairs the activity of COX and estrogen deprivation exacerbates this problem. Five-month-old ovariectomized...

journal_title：Neuroscience letters

authors： Jung ME,Agarwal R,Simpkins JW

更新日期：2007-04-12 00:00:00

abstract：:Although rats often show an upright standing behavior the cardiovascular response during the behavior has not yet been fully clarified. In this study we quantified the activity of upright standing behavior in rats using infrared beam detectors and measured cardiovascular variables during the behavior. Rats demonstrate...

journal_title：Neuroscience letters

authors： Waki H,Katahira K,Yamasaki M,Katsuda S,Shimizu T,Maeda M

更新日期：2009-01-02 00:00:00

abstract：:Different transcription elements have been proposed to play a role in the regulation of acetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3',5'-monophosphate (cAMP)-dependent pathway is one of them. In order to test the possible role of cAMP in regulating the expression of human AChE, an approxima...

journal_title：Neuroscience letters

authors： Wan DC,Choi RC,Siow NL,Tsim KW

更新日期：2000-07-07 00:00:00

abstract：:Mirror neurons, which have now been found in the human and songbird as well as the macaque, respond to both the observation and the performance of the same action. It has been suggested that their matching response properties have evolved as an adaptation for action understanding; alternatively, these properties may a...

journal_title：Neuroscience letters

authors： Catmur C

更新日期：2013-04-12 00:00:00

abstract：:The in vivo effects of the alpha 2-adrenoceptor idazoxan, rauwolscine and phentolamine on alpha 2-auto/heteroreceptors and 5-HT1A autoreceptors modulating the synthesis of dopa/noradrenaline and 5-HTP/serotonin were assessed in rats, using the accumulation of dopa and 5-HTP after decarboxylase inhibition as a measure ...

journal_title：Neuroscience letters

authors： Lladó J,Esteban S,García-Sevilla JA

更新日期：1996-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain against ischemia. To investigate whether resveratrol activates PPARs, w...

journal_title：Neuroscience letters

authors： Inoue H,Jiang XF,Katayama T,Osada S,Umesono K,Namura S

更新日期：2003-12-11 00:00:00

abstract：:Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general...

journal_title：Neuroscience letters

authors： Jiang J,Chen Z,Liang B,Yan J,Zhang Y,Xu H,Huang Y,Jiang H

更新日期：2015-02-19 00:00:00

abstract：:The number of principal neurons in the rat superior cervical ganglion (SCG) exhibiting enkephalin-peptide immunoreactivity is reported to be limited. To better determine the degree of enkephalinergic phenotype in sympathetic neurons, sections of SCGs from rats aged newborn to adult were processed for in situ hybridiza...

journal_title：Neuroscience letters

authors： Greif KF

更新日期：1994-10-24 00:00:00

abstract：:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associate...

journal_title：Neuroscience letters

authors： Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

更新日期：2003-07-10 00:00:00

abstract：:A neurogenic contribution to joint inflammation has been demonstrated in rat adjuvant arthritis, however as inflammatory mechanisms vary between species it is unclear whether these observations can be applied more generally. The aim of this study was to assess the neurogenic contribution to cellular infiltration and o...

journal_title：Neuroscience letters

authors： Hood VC,Cruwys SC,Urban L,Kidd BL

更新日期：2001-02-23 00:00:00

abstract：:Prolactin (PRL) has been shown to be altered by psychotropic drugs, including antidepressant drugs (ADs). Many studies have focused on the response to antidepressant treatment (especially related to the serotonergic system) using the fenfluramine test (PRF), however some data suggest lack of correlation between PRF an...

journal_title：Neuroscience letters

authors： Faron-Górecka A,Kuśmider M,Szafran-Pilch K,Kolasa M,Żurawek D,Gruca P,Papp M,Solich J,Pabian P,Dziedzicka-Wasylewska M

更新日期：2017-04-24 00:00:00

abstract：:Using the Golgi silver impregnation technique the present study examines the morphology and development of presumptive local circuit neurons in lamina III of the rat lumbar spinal cord. These neurons generate local axonal plexuses which remain within the gray matter and dendritic trees which arborize in lamina III and...

journal_title：Neuroscience letters

authors： Beal JA,Russell CT,Knight DS

更新日期：1988-03-21 00:00:00

abstract：:Most fibres in adult muscles are derived from secondary myotubes which form around an earlier developing population of primary myotubes. We examined embryonic rat IVth lumbrical muscles at a stage when most secondary myotubes were less than 24 h old, in order to study their acquisition of synaptic terminals. Single ne...

journal_title：Neuroscience letters

authors： Duxson MJ,Ross JJ,Harris AJ

更新日期：1986-11-11 00:00:00

abstract：:Two types of cone horizontal cells were identified morphologically in the retina of a trichromatic fish by fluorescent labelling with Lucifer Yellow and confocal laser scanning microscopy. H1 cells are located adjacent to the outer plexiform layer, have large somata, small dendritic fields, and contact all cone types....

journal_title：Neuroscience letters

authors： Braun SC,Kröger RH,Wagner HJ

更新日期：1997-10-17 00:00:00

abstract：:The excitability of the motoneuron (MN) pool in the resting state was compared between normal control subjects and patients with spasticity resulting from HTLV-I-associated myelopathy, using a new parameter, Hslp/Mslp, and the conventional parameters Hmax/Mmax and Hth/Mth. Differences in the excitability of the MN poo...

journal_title：Neuroscience letters

authors： Funase K,Higashi T,Yoshimura T,Imanaka K,Nishihira Y

更新日期：1996-01-19 00:00:00

abstract：:The effect of the spectral tone structure on pre-attentive and attentive pitch discrimination was investigated. The mismatch negativity (MMN) component was recorded from reading subjects to pitch changes of identical magnitude in pure tones with only one sinusoidal frequency component and in spectrally rich tones with...

journal_title：Neuroscience letters

authors： Tervaniemi M,Ilvonen T,Sinkkonen J,Kujala A,Alho K,Huotilainen M,Näätänen R

更新日期：2000-01-21 00:00:00

abstract：:Following unilateral electrolytic lesioning of the rat entorhinal cortex, we assessed changes in messenger RNA (mRNA) levels for four neuron-associated proteins, GAP-43, SCG10, 68 kDa neurofilament (NF68), and alpha 1-tubulin that encode proteins of importance to synaptic remodelling. The mRNA levels for GAP-43 and SC...

journal_title：Neuroscience letters

authors： Zarow C,Finch CE

更新日期：1995-02-09 00:00:00

abstract：:This study analyses the finger force sharing using power grip task with adapted experimental conditions. This paradigm limits as much as possible the external constraints when the Index (I), Middle (M), Ring (R) and Little (L) fingers act simultaneously: the thumb did not oppose the other fingers and no secondary mome...

journal_title：Neuroscience letters

authors： Vigouroux L,Rossi J,Foissac M,Grélot L,Berton E

更新日期：2011-10-31 00:00:00

abstract：:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801)...

journal_title：Neuroscience letters

authors： Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

更新日期：1993-10-01 00:00:00

abstract：:Decreased expression of NT-3 mRNA in the sciatic nerve and leg muscles of streptozotocin (STZ)-diabetic rats has been associated with the pathogenesis of diabetic neuropathy. The aim of this study was to determine whether STZ-induced diabetes also affects the expression of NT-3 mRNA in the central and peripheral proje...

journal_title：Neuroscience letters

authors： Cai F,Tomlinson DR,Fernyhough P

更新日期：1999-03-26 00:00:00

abstract：:The mechanism underlying the over-recovery of an M-type potassium current following the washout of muscarine (20 microM) has been examined. Whole-cell recordings were made from single neurons dissociated from bullfrog sympathetic ganglia. During over-recovery, the maximum M-conductance decreased by about 2.8 nS while ...

journal_title：Neuroscience letters

authors： Tokimasa T,Simmons MA,Schneider CR,Akasu T

更新日期：1996-03-29 00:00:00

abstract：:Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G1, G2 and G4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the m...

journal_title：Neuroscience letters

authors： Catalán RE,Martínez AM,Aragonés MD,Hernández F

更新日期：1990-11-27 00:00:00

abstract：:As overweight and obesity are a growing problem in industrialized societies, they become a main focus of many studies. The aim of this study was to determine whether there is an association between the occurrence of polymorphisms in serotonin-related genes and the prevalence of depressive symptoms in obese patients. T...

journal_title：Neuroscience letters

authors： Bieliński M,Tomaszewska M,Jaracz M,Pulkowska-Ulfig J,Długosz D,Sikora M,Tretyn A,Kamińska A,Junik R,Borkowska A

更新日期：2015-01-23 00:00:00

abstract：:The ability of three nitric oxide (NO) donor compounds to modify ligand binding to kainate receptors was studied in tissue from human adult autopsy brains. Binding of [3H]kainic acid (5 nM) was measured in frontal cortex membranes made from Brodmann area 8 (BA 8) and autoradiographically using sections of frontal cort...

journal_title：Neuroscience letters

authors： Lees RD,Slater P,D'Souza SW

更新日期：1997-09-19 00:00:00