Abstract：
:We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kim HJ,Back SK,Kim J,Sung B,Hong SK,Na HSdoi
10.1016/s0304-3940(03)00254-4keywords:
subject
Has Abstractpub_date
2003-05-15 00:00:00pages
109-13issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394003002544journal_volume
342pub_type
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