Differential membrane properties and dopamine effects in the shell and core of the rat nucleus accumbens studied in vitro.

Abstract:

:Electrophysiological differences between the shell and core of the rat nucleus accumbens were investigated by intracellular recordings from an in vitro slice preparation. The average input resistance of neurons recorded in the shell was larger than in the core. Neurons in the core were characterized by a more negative resting membrane potential than neurons in the shell. Furthermore, bath-applied dopamine attenuated synaptic responses recorded in the shell, but not in the core. Thus, the two main subregions of the nucleus accumbens differ both in basal membrane properties and in dopaminergic modulation of synaptic transmission.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pennartz CM,Dolleman-Van der Weel MJ,Lopes da Silva FH

doi

10.1016/0304-3940(92)90660-y

keywords:

subject

Has Abstract

pub_date

1992-02-17 00:00:00

pages

109-12

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90660-Y

journal_volume

136

pub_type

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