Abstract：
:To examine the effect of apolipoprotein E (ApoE) 4 on the progression of Alzheimer's disease (AD), the clinical course of 33 AD patients (17 cases with ApoE epsilon4 and 16 cases without ApoE epsilon4) was evaluated with the mini-mental state examination (MMSE) and cerebrospinal fluid (CSF) biological markers. The decline of MMSE scores to zero was shortened in the ApoE4 group. During a mean follow-up of 20 months, a significant increase of CSF tau levels was observed in the ApoE4 group. A lower level of CSF A beta1-42(43) was found in both the ApoE4 and non-ApoE4 groups than in age-matched normal controls. The ApoE epsilon4 allele accelerates the progression of dementia and increases the levels of CSF tau in AD patients.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kanai M,Shizuka M,Urakami K,Matsubara E,Harigaya Y,Okamoto K,Shoji Mdoi
10.1016/s0304-3940(99)00323-7keywords:
subject
Has Abstractpub_date
1999-05-21 00:00:00pages
65-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00323-7journal_volume
267pub_type
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